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Keywords: Wnt
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Journal Articles
Journal: Development
Development (2023) 150 (23): dev202168.
Published: 7 December 2023
... inhibited tooth formation. Thus, similar to known roles in hair regeneration, Wnt and BMP signals promote and inhibit regeneration, respectively. Regulation of total tooth number was separable from regulation of replacement rates. RNA sequencing of stickleback dental tissue showed that Bmp6 overexpression...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (6): dev201048.
Published: 23 March 2023
..., which allows SHH and BMP4 signaling and the formation of the ureter. Ureter Kidney Repression Tbx18 Wt1 Wnt Bmp4 Shh Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 DFG KI728/7-2 The organs of the upper urinary system, the (metanephric) kidneys...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200515.
Published: 16 June 2022
... with that of diffusion of locally expressed Wnt ligands, suggesting a cooperative relationship between these two PCP regulators. Next, we considered the possibility that the tension-induced change in cell shape might act as a cue for PCP. When a tissue is stretched uniaxially, the cells also elongate in the same...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200125.
Published: 30 March 2022
...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (6): dev200472.
Published: 18 March 2022
... of adhesion, including activation of latent-TGFβs in the ECM. Quantitative sequencing of the brain endothelial cell transcriptome identifies TGFβ-regulated genes with putative links to blood vessel morphogenesis, including several genes linked to Wnt/β-catenin signaling. These results reveal that the β8...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199505.
Published: 10 January 2022
... mechanisms underlying the epithelial-mesenchymal interaction during alveologenesis are poorly understood. Here, we report that Wnts produced by epithelial cells are crucial for neonatal alveologenesis. Deletion of the Wnt chaperone protein Wntless homolog (Wls) disrupts alveolar formation, resulting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199984.
Published: 4 January 2022
... to overproliferation of interstitial cells regionally in the kidney medulla. Analysis of markers for BMP and TGFβ pathway activation reveals that loss of Smad4 primarily reduces TGFβ signaling in the interstitium. Whereas TGFβ signaling is reduced in these cells, marker analysis shows that Wnt/β-catenin signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (20): dev199629.
Published: 19 October 2021
... quiescent and are stimulated by niche signals to activate and produce neurons. Wnt/β-catenin signalling acts at different steps along the hippocampal neurogenic lineage, but whether it has a direct role in the regulation of NSCs remains unclear. Here, we used Wnt/β-catenin reporters and transcriptomic data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
...), that is required for the progression of tooth development. IK cell dynamics demonstrate the hallmarks of a signaling center: cell cycle exit, condensation and eventual silencing through apoptosis. IK initiation and maturation are defined by the juxtaposition of cells with high Wnt activity to Shh -expressing non...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
.... Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev186080.
Published: 23 July 2020
... pathway, that increases Wnt production from motor neurons. We also provide evidence that this neuronal Wnt contributes to EGL-30-stimulated vulval development, with muscle producing a parallel developmental signal. As diverse sensory modalities stimulate motor neurons via acetylcholine, this mechanism...
Includes: Supplementary data
Journal Articles