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Keywords: Wnt
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200125.
Published: 30 March 2022
...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200472.
Published: 18 March 2022
... of adhesion, including activation of latent-TGFβs in the ECM. Quantitative sequencing of the brain endothelial cell transcriptome identifies TGFβ-regulated genes with putative links to blood vessel morphogenesis, including several genes linked to Wnt/β-catenin signaling. These results reveal that the β8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199587.
Published: 12 January 2022
...Soumyashree Das; Qiang Feng; Iyshwarya Balasubramanian; Xiang Lin; Haoran Liu; Oscar Pellón-Cardenas; Shiyan Yu; Xiao Zhang; Yue Liu; Zhi Wei; Edward M. Bonder; Michael P. Verzi; Wei Hsu; Lanjing Zhang; Timothy C. Wang; Nan Gao ABSTRACT Although Wnt signaling is clearly important for the intestinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199505.
Published: 10 January 2022
... mechanisms underlying the epithelial-mesenchymal interaction during alveologenesis are poorly understood. Here, we report that Wnts produced by epithelial cells are crucial for neonatal alveologenesis. Deletion of the Wnt chaperone protein Wntless homolog (Wls) disrupts alveolar formation, resulting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199984.
Published: 4 January 2022
... to overproliferation of interstitial cells regionally in the kidney medulla. Analysis of markers for BMP and TGFβ pathway activation reveals that loss of Smad4 primarily reduces TGFβ signaling in the interstitium. Whereas TGFβ signaling is reduced in these cells, marker analysis shows that Wnt/β-catenin signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (20): dev199629.
Published: 19 October 2021
... quiescent and are stimulated by niche signals to activate and produce neurons. Wnt/β-catenin signalling acts at different steps along the hippocampal neurogenic lineage, but whether it has a direct role in the regulation of NSCs remains unclear. Here, we used Wnt/β-catenin reporters and transcriptomic data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
...), that is required for the progression of tooth development. IK cell dynamics demonstrate the hallmarks of a signaling center: cell cycle exit, condensation and eventual silencing through apoptosis. IK initiation and maturation are defined by the juxtaposition of cells with high Wnt activity to Shh -expressing non...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
.... The roles played by this ligand in hChP development have not been addressed to date. Although Wnt3 does not appear to activate canonical Wnt-β catenin signaling, it has been shown to activate MAPK signaling in cerebellar granule cell progenitors, antagonizing SHH-induced clonal expansion ( Anne et al., 2013...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
.... Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev186080.
Published: 23 July 2020
... pathway, that increases Wnt production from motor neurons. We also provide evidence that this neuronal Wnt contributes to EGL-30-stimulated vulval development, with muscle producing a parallel developmental signal. As diverse sensory modalities stimulate motor neurons via acetylcholine, this mechanism...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... molecular signals ensure ovary versus testis differentiation with canonical Wnt/β-catenin signals paramount for promoting the ovary pathway. Notably, few direct downstream targets have been identified. We report that Wnt/β-catenin signaling directly stimulates Irx3 and Irx5 transcription in the developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev182865.
Published: 16 March 2020
... are an excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, remained...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish The term ‘cardiac looping’ defines a morphogenetic process during vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 8 November 2019
.... , Chambers , I. and Smith , A. ( 2002 ). Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation . Nat. Biotechnol.   20 , 1240 - 1245 . 10.1038/nbt763 Aubert , J. , Stavridis , M. P. , Tweedie , S. , O'Reilly , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... and breast by suppressing mitogenic WNT signaling in mouse. In striking contrast to these systems, we found that co-deleting Gsk3a and Gsk3b blocked CGNP proliferation, causing severe cerebellar hypoplasia. The GSK-3 inhibitor CHIR-98014 similarly downregulated SHH-driven proliferation. Transcriptomic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 9 August 2019
...Varun Chaudhary; Swapnil Hingole; Jana Frei; Fillip Port; David Strutt; Michael Boutros ABSTRACT Wnts are secreted proteins that regulate cell fate during development of all metazoans. Wnt proteins were proposed to spread over several cells to activate signaling directly at a distance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
...Elena Sena; Nathalie Rocques; Caroline Borday; Harem Sabr Muhamad Amin; Karine Parain; David Sitbon; Albert Chesneau; Béatrice C. Durand ABSTRACT A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on the cell and developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
..., we show that wnt9a and wnt9b are induced in the injured kidney at sites where frizzled9b - and lef1 -expressing progenitor cells form new nephrons. New nephron aggregates are patterned by Wnt signaling, with high canonical Wnt-signaling cells forming a single cell thick rosette that demarcates...
Includes: Supplementary data