... generation at apical, lateral or basal sides of epithelial Drosophila wing disc cells, an important model for studying morphogenesis. We show that optogenetic recruitment of RhoGEF2 to apical, lateral or basal cell sides leads to local accumulation of F-actin and increase in mechanical tension. Increased...

... primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-specific. Signaling...

...Liyuan Sui; Christian Dahmann ABSTRACT The modulation of mechanical tension is important for sculpturing tissues during animal development, yet how mechanical tension is controlled remains poorly understood. In Drosophila wing discs, the local reduction of mechanical tension at basal cell edges...

... ; Smith-Bolton et al., 2009 ). After irradiation, hinge cells autonomously require Stat92E to participate in pouch reconstruction ( Verghese and Su, 2016 ), indicating a crucial function of JAK/STAT signaling in cell reprogramming. JAK/STAT signaling in the regenerating wing disc may also have...

... be reprogrammed to regenerate each other. Drosophila Wing disc Regeneration Trunk Appendages JNK Regeneration is a widespread phenomenon that has been observed in many different animal groups (reviewed by Tanaka and Reddien, 2011 ); it refers to the response process triggered by injury...

... of tumor growth and metastasis, Capicua may be an important target of the COP9 signalosome in cancer. Fig. 6. CSN subunits protect Cic from EGFR-dependent and -independent modes of degradation. (A,B) Wing discs expressing UAS-Cic ΔC2 -HA (HA stained in A′,B′, blue in A,B) in the dorsal domain using...

... scales with the growing tissue size, tissue growth becomes spatially uniform and the tissue naturally attains a finite size. This model is consistent with many properties of the wing disc. However, we find that the MDDR is not consistent with the phenotype of scaling-defective mutants, supporting...

...Jeremiah Zartman; Simon Restrepo; Konrad Basler The Drosophila wing imaginal disc is a key model organ for molecular developmental genetics. Wing disc studies are generally restricted to end-point analyses of fixed tissues. Recently several studies have relied on limited data from discs cultured...

... of a region of the disc could be performed and regeneration monitored without the requirement for microsurgical manipulation. Using a ptc-Gal4 construct to drive rpr expression in the wing disc resulted in a stripe of dead cells in the anterior compartment flanking the anteroposterior boundary, whereas a sal...

...Francisco A. Martín; Salvador C. Herrera; Ginés Morata We report here experiments aimed at understanding the connections between cell competition and growth in the Drosophila wing disc. The principal assay has been to generate discs containing marked cells that proliferate at different rates...

...Francisco A. Martín; Ginés Morata The mechanisms that control organ growth are among the least known in development. This is particularly the case for the process in which growth is arrested once final size is reached. We have studied this problem in the wing disc of Drosophila...

... filaments, are specifically required in the wing blade primordium of the Drosophila wing disc. cpa or cpb mutant cells in this region, but not in the remainder of the wing disc, are extruded from the epithelium and undergo apoptosis. Excessive actin filament polymerization is not sufficient to explain...

... but X-rays can induce high apoptotic levels,which eliminate a large fraction of the disc cells. Nevertheless, irradiated discs form adult patterns of normal size, indicating the existence of compensatory mechanisms. We have characterised the apoptotic response of the wing disc to X-rays and heat shock...

... brinker (brk) , which encodes a transcriptional repressor and is negatively regulated by the Dpp pathway. We have studied how alterations in the Brk gradient affect the growth of the wing disc. We find that there is a negative correlation between brk activity and growth of the disc:high levels of brk...

..., optomotor-blind ( omb ) and brinker ( brk ),collaborate to initiate formation of the fifth longitudinal (L5) wing vein. omb is broadly expressed at the center of the wing disc in a pattern complementary to that of brk , which is expressed in the lateral regions of the disc and represses omb expression. We...

..., while ectopic Egfr activation results in notum specification. These findings suggest that suppression of Wg and Egfr activities is an early step in the development of the peripodial epithelium of the wing discs. † Authors for correspondence (e-mail: abaena@cbm.uam.es and jcpastor@cbm.uam.es...

... 2000 Wing disc homothorax wingless decapentaplegic vestigial Drosophila In the body of Drosophila , there is a clear distinction between the main body trunk and the cephalic and thoracic appendages. These are formed by the derivatives of the imaginal discs that also contribute...

... 11 1996 © 1997 by Company of Biologists 1997 axis formation Drosophila Wingless wing disc cell fate During development of multicellular organisms the growth and patterning of groups of cells are coordinated in a manner that suggests that cell fate is being controlled...

... is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary. * e-mail: scohen@embl-heidelberg.de 13 9 1995 © 1995 by Company of Biologists 1995 Serrate Notch Wingless compartment boundary pattern formation wing disc...

... proposed to be paramount in the specification of the posterior compartment identity. Here, we explore the adult en function by targeting its expression in different regions of the wing disc. In the anterior compartment, ectopic en expression gives rise to the substitution of anterior structures...