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Keywords: WNT4
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (23): dev201093.
Published: 30 November 2022
... with the contralateral descended testis (CDT) showing no A-dark spermatogonia. To improve our understanding of the etiology of infertility in UDT, we generated a novel murine model of left unilateral UDT. Gubernaculum-specific Wnt4 knockout (KO) mice ( Wnt4 -cKO) were generated using retinoic acid receptor β2- cre mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199281.
Published: 15 June 2021
... and differentiation of hormone receptor expressing (HR + ) luminal cells. Consequently, Wnt4-mediated crosstalk between HR + luminal cells and basal epithelial cells is compromised during gland remodeling, and results in defective epithelial growth. The effects of Lama5 deletion on gland growth and branching can...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (1): dev191189.
Published: 13 January 2021
... cryptorchidism with severe gubernacular defects and progressive loss of germ cells resulting in infertility and, in rare cases, testicular tumors. It was hypothesized that germ cell depletion resulted from an increase in WNT4 levels. To test this hypothesis, the phenotype of a double-null mouse model lacking...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4530–4539.
Published: 15 December 2017
..., it promotes nephrogenesis by upregulating Lhx1 and Hnf1b . Notch Nephron segmentation Nephrogenesis Kidney development Wnt4 Six2 Mouse In mammals, nephrons are formed only during development ( McMahon, 2016 ). At the cortex of the developing kidney, mesenchymal nephron progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1778–1787.
Published: 15 May 2016
.... Our results show that E-cadherin is intensely expressed in germline cysts, and that its decline is necessary for oocyte release from the cyst. However, inhibition of JNK signaling leads to aberrantly enhanced localization of E-cadherin at oocyte-oocyte contact sites. WNT4 expression is upregulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4461–4472.
Published: 1 December 2012
... is activated by the expression of the Y-linked gene Sry , which promotes cell proliferation and differentiation of Sertoli cells, the supporting cells of the testis. In absence of Sry (XX individuals), activation of WNT/CTNNB1 signalling, via the upregulation of Rspo1 and Wnt4 , promotes ovarian...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1967–1975.
Published: 15 May 2011
...) is secreted by the fetal testes and induces regression of the Müllerian ducts, the primordia of the female reproductive tract organs. Currently, the molecular identity of downstream events regulated by the AMH signaling pathway remains unclear. We found that male-specific Wnt4 expression in mouse Müllerian...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 129–138.
Published: 1 January 2009
... to a time window of only 6 hours after the normal onset of Sry expression in XY gonads. If Sry was activated after 11.3 dpc, Sox9 activation was not maintained, resulting in ovarian development. This time window is delimited by the ability to engage the high-FGF9/low-WNT4 signaling states required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (17): 3177–3190.
Published: 1 September 2007
.... An important remaining question is the nature of the extracellular signal that triggers β-catenin/TCF/Lef signaling in the organ culture system and in vivo. Wnt4 seems an obvious candidate based on an upregulation we observe in differentiating metanephric explants and co-expression of Wnt4 and TCF/Lef target...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2017–2025.
Published: 1 June 2007
..., the salivary gland responds to a WNT4-Frizzled signal for proper positioning within the embryo. Disruption of this signal, through mutations in Wnt4, frizzled or frizzled 2 , results in misguided salivary glands that curve ventrally. Furthermore, disruption of downstream components of the canonical Wnt pathway...
Journal Articles
Journal: Development
Development (2007) 134 (4): 801–811.
Published: 15 February 2007
... 2006 © 2007. 2007 Notch Rbp-J Wnt4 Proximal tubule Podocytes Nephron segmentation Mouse The kidney is an essential excretory organ that maintains osmotic,acid-base and electrolyte equilibrium. The crucial importance of the kidney makes it a common target of systemic diseases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (17): 3859–3871.
Published: 1 September 2005
... hypoplasia with deficient nephron formation. In mutant kidneys, aberrant cell death occurs within the metanephric mesenchyme (MM),particularly in the cortical nephrogenic zone, which provides the progenitors for recurring rounds of nephron formation. Prior to mutant morphological changes, Wnt4 and Lim1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (17): 3847–3857.
Published: 1 September 2005
... signaling, nephron formation is initiated, but the nascent nephrons do not express Wnt4 or Lim1 , and nephrogenesis does not progress to the S-shaped body stage. Furthermore, the nephron progenitor cells that reside in the peripheral zone, the outermost region of the developing kidney, are progressively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (3): 539–549.
Published: 1 February 2004
... starts to regress at this stage( Torres et al., 1995 ). Wnt4 is one of relatively few molecules that have been shown to be required for the initial steps of Müllerian duct formation. It was reported that there is no Müllerian duct in Wnt4 mutants by molecular expression analysis...