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Keywords: WNT signaling
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Journal Articles
Journal: Development
Development (2022) 149 (14): dev200154.
Published: 14 July 2022
... deletion showed that melanocytes and immune cells dynamically follow epithelial scale:interscale patterns. Importantly, disrupting Wnt-Lef1 function in keratinocytes caused melanocyte mislocalization to interscale epidermis, implicating canonical Wnt signaling in organizing the pigmentation pattern...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200335.
Published: 11 July 2022
... be addressed with in vitro models of human embryos that are derived from embryonic stem cells (hESCs). Our previous work demonstrated that during early stages of hESC differentiation, cells chronicle signaling hierarchy. Only cells that have been exposed (primed) by WNT signaling can respond to subsequent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (9): dev200340.
Published: 12 May 2022
... the severe hind limb defects caused by replacement of the one remaining WT Reck allele by Reck PW , which is defective specifically in WNT signaling (white arrows). (C,D) Genetic crosses to remove Gpr124 and/or Reck in the caudal region of the early embryo ( Cdx2-Cre ) or in the limb mesenchyme...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199685.
Published: 22 July 2021
... pathway have shown that tooth formation is partly inhibited in loss-of-function mutants, and gain-of-function mutants have perturbed tooth morphology. However, the stage at which Wnt signaling is first important in tooth formation remains unclear. Here, using an Fgf8 -promoter-driven, and therefore early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
... for in vivo Hox13-binding sites in the zebrafish tailbud reveals a highly conserved enhancer element necessary for NMp expression of brachyury and body axis elongation . Hox genes Brachyury Wnt signaling Neuromesodermal progenitors All vertebrate embryos form their anterior-posterior...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev198846.
Published: 29 April 2021
... for reproduction, but how this is achieved is unclear. Here, we show that canonical wingless-type MMTV integration site family (WNT) signaling is pivotal for pre-granulosa cell (pre-GC) activation during PFA. We identified several WNT ligands expressed in pre-GCs that act in an autocrine manner. Inhibition of WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
...-posterior axis patterning. Wnt signaling Axin Sea urchin Anterior-posterior axis Animal-vegetal axis Endomesoderm During embryonic development in most bilaterally symmetrical animals (Bilateria), the establishment of the anterior-posterior (AP) and dorsal-ventral (DV) axes are two early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... by The Company of Biologists Ltd 2021 Summary: To model human birth defects caused by DDX3X mutations, we show that Xenopus DDX3 induces neural crest via the AKT-GSK3β axis, which promotes Wnt signaling and Snai1 stability. DDX3 Neural crest (NC) AKT GSK3β Wnt signaling Xenopus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
.... Androgen signaling Prostate development Wnt signaling Sonic hedgehog signaling Mouse models Summary: Using newly generated mouse genetic tools, we demonstrate the dynamic regulation of mesenchymal androgen signaling as cellular niches controlling prostate early development. © 2021...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
... in ensuring development of the posterior body in zebrafish through sustaining the tailbud-derived bipotential neuromesodermal progenitors. Hox genes Brachyury Wnt signaling Neuromesodermal progenitors A hallmark of early embryonic vertebrate development is the progressive formation...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (22): dev192518.
Published: 19 November 2020
..., and live cell imaging reveals aberrant recycling of the WNT ligand-binding protein WLS and mis-trafficking to the lysosome for degradation. The importance of SNX3 in WNT signaling regulation is demonstrated by rescue of NT closure in Snx3 −/− embryos with a WNT agonist. The potential for SNX3 to function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev185678.
Published: 2 September 2020
.... Deficiency of epithelial Erk1/2 results in defects in secretory cell differentiation as well as impaired mesenchymal cell proliferation and maturation. Deletion of Erk1/2 strongly activated Wnt signaling through both cell-autonomous and non-autonomous mechanisms. In epithelial cells, Erk1/2 depletion...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (12): dev189977.
Published: 22 June 2020
.... β cell differentiation Retinoic acid signaling Wnt signaling Pancreas development Diabetes δ cell specification Cell signaling pathways are used continuously throughout development and adulthood to mediate tissue interactions and precisely control gene expression. In particular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
... to proliferative cell division, the C. elegans RNT-1/BRO-1 transcriptional repressor opposes POP-1 TCF expression in seam stem cells, which turns POP-1-induced differentiation into self-renewal. C. elegans Wnt signaling Runx Asymmetric cell division Stem cell division mode Transcriptional regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
...George Britton; Idse Heemskerk; Rachel Hodge; Amina A. Qutub; Aryeh Warmflash ABSTRACT During development, the ectoderm is patterned by a combination of BMP and WNT signaling. Research in model organisms has provided substantial insight into this process; however, there are currently no systems...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev179580.
Published: 9 August 2019
... with ring patterns. Manipulation of FGF or Wnt signaling demonstrated that ‘ring’ genes are responsive to FGF signaling at the dorsal midline, whereas ‘horseshoe’ genes are predominantly regulated by Wnt signaling. We suggest that, in the absence of active β-catenin at the dorsal midline, the DNA-binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 2 July 2019
... interactions that prevent β-catenin degradation. Surprisingly, the nucleus is surrounded by active DCs, which principally control the degradation of β-catenin and thereby nuclear access. These DCs are inactivated and removed upon Wnt signal transduction. These results suggest a novel mechanistic model...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
... controls neuronal migration in metazoans, in addition to many other aspects of neural development. We show that Caenorhabditis elegans VANG-1, a membrane protein that acts in the planar cell polarity (PCP) pathway, antagonizes Wnt signaling by facilitating endocytosis of the Frizzled receptors. Mutations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
... canonical WNT signaling. Loss of TBX2/TBX3 in this region disrupts activity of two crucial drivers of the SMC program, Foxf1 and BMP4 signaling, resulting in decreased SMC differentiation and increased extracellular matrix. Transcriptional profiling and chromatin immunoprecipitation experiments revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev162388.
Published: 29 October 2018
... profiling of the regenerating feather blastema revealed that Wnt signaling is among the most active pathways during feather regeneration, with Wnt ligands and their inhibitors showing distinct expression patterns. Co-expression analysis identified hundreds of lncRNAs with similar expression patterns...
Includes: Supplementary data