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Keywords: WNT/β-catenin signaling
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev198101.
Published: 29 April 2021
... embryos, eif4a3 depletion inhibited the development of the dorsal organizer and pattern formation of the anterior neuroectoderm by increasing Wnt/β-catenin signaling. Conversely, overexpression of eif4a3 decreased Wnt/β-catenin signaling and inhibited the formation of the dorsal organizer before...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev185140.
Published: 24 August 2020
... blood-brain barrier (BBB) that is necessary for neuronal survival and activity. Although Wnt/β-catenin signaling is essential for BBB development, its downstream targets within the neurovasculature remain poorly understood. To identify targets of Wnt/β-catenin signaling underlying BBB maturation, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177659.
Published: 15 July 2019
... tissues, indicating a role of Sall4 in NMP differentiation balance. Mechanistically, we show that Sall4 promotion of WNT/β-catenin signaling contributes to NMP maintenance and differentiation balance. RNA-Seq and SALL4 ChIP-Seq analyses support the notion that Sall4 regulates both mesodermal and neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168351.
Published: 27 November 2018
... in a temporal- and spatial-specific manner. Here, we show that WNT/β-catenin signaling is crucial for myoblast fusion through regulation of the nephrin ( Nphs1 ) gene in the Myog-Cre -expressing myoblast population. Mice deficient for the β-catenin gene in Myog-Cre -expressing myoblasts ( Ctnnb1 F/F ;Myog-Cre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2824–2836.
Published: 1 August 2017
...Youngwook Ahn; Carrie Sims; Megan J. Murray; Paige K. Kuhlmann; Jesús Fuentes-Antrás; Scott D. Weatherbee; Robb Krumlauf During development and homeostasis, precise control of Wnt/β-catenin signaling is in part achieved by secreted and membrane proteins that negatively control activity of the Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1687–1697.
Published: 1 May 2017
...Xiaozhi Rong; Yumei Zhou; Yunzhang Liu; Beibei Zhao; Bo Wang; Caixia Wang; Xiaoxia Gong; Peipei Tang; Ling Lu; Yun Li; Chengtian Zhao; Jianfeng Zhou The Wnt/β-catenin signaling pathway plays pivotal roles in axis formation during embryogenesis and in adult tissue homeostasis. Glutathione peroxidase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 1041–1054.
Published: 15 March 2016
... spatiotemporal inhibition of Wnt/β-catenin signaling by chemically inducible overexpression of Dkk1. Unexpectedly, this approach indicates canonical Wnt signaling is required for EMT in the proximal outflow tract (pOFT) but not atrioventricular canal (AVC) cushions. Furthermore, Wnt indirectly promotes pOFT EMT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3383–3393.
Published: 1 October 2015
... of a coordinated developmental process based on mesenchymal-epithelial interactions. The molecular mechanism underlying these interactions remains unclear. The Wnt/β-catenin signaling pathway is involved in fundamental aspects of development through the regulation of various growth factors. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 148–157.
Published: 1 January 2014
... and body axis elongation. PCP signaling gene mutations cause severe neural tube defects (NTDs). However, the role of canonical Wnt/β-catenin signaling in neural tube closure and NTDs remains poorly understood. This study shows that conditional gene targeting of β-catenin in the dorsal neural folds of mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 583–593.
Published: 1 February 2013
...Youngwook Ahn; Carrie Sims; Jennifer M. Logue; Scott D. Weatherbee; Robb Krumlauf The future site of skin appendage development is marked by a placode during embryogenesis. Although Wnt/β-catenin signaling is known to be essential for skin appendage development, it is unclear which cellular...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 514–524.
Published: 1 February 2012
...Alissa Caron; Xiaolei Xu; Xueying Lin Cilia are essential for normal development. The composition and assembly of cilia has been well characterized, but the signaling and transcriptional pathways that govern ciliogenesis remain poorly studied. Here, we report that Wnt/β-catenin signaling directly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 427–436.
Published: 1 February 2009
... osteoblasts, which are known to lack normal intracellular GC signaling. Fig. 5. Wnt/β-catenin signaling is reduced in neonatal (P0) transgenic parietal bone and cartilage. ( A , B ) Immunohistochemistry forβ-catenin at regions of overlapping bone and cartilage in P0 parietal bones. Arrows indicate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (11): 2599–2609.
Published: 1 June 2005
...Heiko Lickert; Brian Cox; Christian Wehrle; Makoto M. Taketo; Rolf Kemler; Janet Rossant Differential gene regulation integrated in time and space drives developmental programs during embryogenesis. To understand how the program of gastrulation is regulated by Wnt/β-catenin signaling, we have used...
Includes: Supplementary data