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Keywords: WNT
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Journal Articles
Journal: Development
Development (2022) 149 (20): dev200679.
Published: 14 September 2022
... show that hypoxia-induced T expression enables symmetry breaking and axial elongation in the absence of exogenous WNT activation. When combined with exogenous WNT activation, hypoxia enhances lineage representation in gastruloids, as demonstrated by highly enriched signatures of gut endoderm, notochord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200353.
Published: 9 September 2022
...Keagan Dunville; Fabrizio Tonelli; Elena Novelli; Azzurra Codino; Verediana Massa; Anna Maria Frontino; Silvia Galfrè; Francesca Biondi; Stefano Gustincich; Matteo Caleo; Luca Pandolfini; Claudia Alia; Federico Cremisi ABSTRACT Using the timely re-activation of WNT signalling in neuralizing human...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (14): dev200533.
Published: 22 July 2022
.... Conditional inactivation of the Wnt secretion protein Wls in Pax3-expressing lineage cells disrupted frontonasal primordial patterning, cell survival and directional outgrowth, resulting in altered facial structures, including midfacial hypoplasia and midline facial clefts. Single-cell RNA sequencing revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200515.
Published: 16 June 2022
... with that of diffusion of locally expressed Wnt ligands, suggesting a cooperative relationship between these two PCP regulators. The posterior neuroectoderm was dissected from stage 10.5 embryo in 1×Steinberg's solution. The explant was immediately placed on a stretch chamber STB-CH-04 (Strex) coated with fibronectin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200125.
Published: 30 March 2022
...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (6): dev200472.
Published: 18 March 2022
... of adhesion, including activation of latent-TGFβs in the ECM. Quantitative sequencing of the brain endothelial cell transcriptome identifies TGFβ-regulated genes with putative links to blood vessel morphogenesis, including several genes linked to Wnt/β-catenin signaling. These results reveal that the β8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199587.
Published: 12 January 2022
...Soumyashree Das; Qiang Feng; Iyshwarya Balasubramanian; Xiang Lin; Haoran Liu; Oscar Pellón-Cardenas; Shiyan Yu; Xiao Zhang; Yue Liu; Zhi Wei; Edward M. Bonder; Michael P. Verzi; Wei Hsu; Lanjing Zhang; Timothy C. Wang; Nan Gao ABSTRACT Although Wnt signaling is clearly important for the intestinal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199505.
Published: 10 January 2022
... mechanisms underlying the epithelial-mesenchymal interaction during alveologenesis are poorly understood. Here, we report that Wnts produced by epithelial cells are crucial for neonatal alveologenesis. Deletion of the Wnt chaperone protein Wntless homolog (Wls) disrupts alveolar formation, resulting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199984.
Published: 4 January 2022
... to overproliferation of interstitial cells regionally in the kidney medulla. Analysis of markers for BMP and TGFβ pathway activation reveals that loss of Smad4 primarily reduces TGFβ signaling in the interstitium. Whereas TGFβ signaling is reduced in these cells, marker analysis shows that Wnt/β-catenin signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (20): dev199629.
Published: 19 October 2021
... quiescent and are stimulated by niche signals to activate and produce neurons. Wnt/β-catenin signalling acts at different steps along the hippocampal neurogenic lineage, but whether it has a direct role in the regulation of NSCs remains unclear. Here, we used Wnt/β-catenin reporters and transcriptomic data...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev194597.
Published: 29 April 2021
...), that is required for the progression of tooth development. IK cell dynamics demonstrate the hallmarks of a signaling center: cell cycle exit, condensation and eventual silencing through apoptosis. IK initiation and maturation are defined by the juxtaposition of cells with high Wnt activity to Shh -expressing non...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
... , 312 - 320 . 10.1002/pmic.200500085 Parr , B. A. , Shea , M. J. , Vassileva , G. and McMahon , A. P. ( 1993 ). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds . Development   119 , 247 - 261 . Pignatti , E. , Leng...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
.... Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev186080.
Published: 23 July 2020
... pathway, that increases Wnt production from motor neurons. We also provide evidence that this neuronal Wnt contributes to EGL-30-stimulated vulval development, with muscle producing a parallel developmental signal. As diverse sensory modalities stimulate motor neurons via acetylcholine, this mechanism...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... molecular signals ensure ovary versus testis differentiation with canonical Wnt/β-catenin signals paramount for promoting the ovary pathway. Notably, few direct downstream targets have been identified. We report that Wnt/β-catenin signaling directly stimulates Irx3 and Irx5 transcription in the developing...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (6): dev182865.
Published: 16 March 2020
... are an excellent model for investigating how signaling control facilitates the generation of defined neuronal populations. Wnt signaling is required for habenular neuron type specification, asymmetry and axonal connectivity. The temporal regulation of this pathway and the players involved have, however, remained...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
...: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish For pharmacological treatments, embryos were incubated in egg-water supplemented with 20 μM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 8 November 2019
... in a dampening of the transcriptional response to Wnt in differentiating neural progenitors; this is in keeping with similar findings in some cell types ( Hendriksen et al., 2008 ; Orsulic et al., 1999 ; Van De Wetering et al., 2001 ), but contrasts with findings in other contexts where changes in E-cadherin...
Includes: Supplementary data