... this IKNM range [i.e. the thickness of a pseudostratified ventricular zone (VZ)] is determined remains unknown. Here, we report external fencing of IKNM and the VZ by differentiating cells. When a tight stack of multipolar cells immediately basal to the VZ was ‘drilled’ via acute neuron-directed expression...

... (LIF)/gp130 signaling plays a role in the development of the germinal layers in the lateral ganglionic eminence. We found that CNTF/LIF/gp130 receptor signaling promotes the self-renewal/expansion of a subpopulation of fibroblast growth factor-responsive ventricular zone (VZ) precursors in the ventral...

... Neurosphere Cre/lox Stem cell niche Ventricular zone Subventricular zone Neural stem cells are defined as cells able to undergo self-renewing divisions, and form both neurones and the two classes of glial cell in the CNS, astrocytes and myelin-forming oligodendrocytes. Studies using cell culture...

... Cell proliferation Asymmetrical cell division p27 Kip1 Ventricular zone The adult neocortex (hereafter called the cortex) is composed of six radial layers of neurones, each defined by cellular morphology, cell density and the formation of distinct axonal connections. During development...

...Sally Temple; Andrew A. Davis ABSTRACT Ventricular zone cells in the developing CNS undergo extensive cell division in vivo and under certain conditions in vitro. The culture conditions that promote cell division have been studied to determine the role that contact with cell membrane associated...