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Keywords: Vasa
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Journal Articles
Journal: Development
Development (2022) 149 (22): dev200982.
Published: 18 November 2022
... is that we never see Nodal pathway members within Nanos/Vasa-positive cells in the region known to give rise to the primordial germ cells (PGCs). The results from this work contrast the results of PGC specification in the sea urchin, and the dataset presented here enables deeper comparative studies...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (20): dev179572.
Published: 14 October 2019
... phenotype due to a reduction in germ cell number, an increase in germ cell apoptosis and the failure of gonads to differentiate into normal testes or ovaries. Moreover, arginine methylation of the germ cell-specific proteins Zili and Vasa, as well as histones H3 (H3R8me2s) and H4 (H4R3me2s), was reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev155663.
Published: 22 January 2018
... and then in the left side of the embryo where the germ cells form a posterior enterocoel. We find that Nodal signaling is required for the restriction of two germ cell factors, Nanos and Vasa, during the early development of this animal. We learned that Nodal inhibits germ cell factor accumulation in three ways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 1960–1970.
Published: 1 June 2015
...Mamiko Yajima; Gary M. Wessel ABSTRACT Vasa is a conserved RNA-helicase found in the germ lines of all metazoans tested. Whereas Vasa presence is often indicated as a metric for germline determination in animals, it is also expressed in stem cells of diverse origin. Recent research suggests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3786–3794.
Published: 15 October 2012
..., including selective Vasa protein accumulation and transcriptional activation of nanos ; their descendants are passively displaced towards the animal pole by secondary mesenchyme cells and the elongating archenteron during gastrulation; Cadherin (G form) has an important role in their development...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2217–2222.
Published: 1 June 2011
...Mamiko Yajima; Gary M. Wessel Vasa is a broadly conserved ATP-dependent RNA helicase that functions in the germ line of organisms from cnidarians to mammals. Curiously, Vasa is also present in the somatic cells of many animals and functions as a regulator of multipotent cells. Here, we report...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (2): 237–243.
Published: 15 January 2011
... to be such multipotent cells: they are relatively quiescent in embryos, but contribute significantly to the coelomic sacs of the larvae, from which the major tissues of the adult rudiment are derived. These cells appear to be regulated by a conserved gene set that includes the classic germline lineage genes vasa, nanos...
Journal Articles
Journal: Development
Development (2010) 137 (24): 4113–4126.
Published: 15 December 2010
... other taxa segregate their germline after embryogenesis from multipotent progenitor cells. An overlapping set of genes, including vasa, nanos and piwi , operate in both multipotent precursors and in the germline. As we propose here, this conservation implies the existence of an underlying germline...
Journal Articles
Journal: Development
Development (2009) 136 (20): 3485–3494.
Published: 15 October 2009
..., and we are interested in both the origins and the persistence of stem cells responsible for asexual development in colonial ascidians. In this study, we characterized vasa as a putative marker of germline precursors. We found that maternally deposited vasa mRNA segregates early in development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3383–3392.
Published: 15 September 2007
... and stabilized by CSN-5. We propose the `good cop: bad cop' team of CSN-5 and KGB-1 imposes a balance on GLH-1 levels, resulting in germline homeostasis. In addition, both KGB-1 and CSN-5 bind Vasa, a Drosophila germ granule component; therefore, similar regulatory mechanisms might be conserved from worms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (14): 2683–2693.
Published: 15 July 2006
... as the germ plasm, it is also highly enriched in several factors essential for somatic cell development, and how the postplasm components regulate both germ and somatic cell differentiation remains elusive. Using a vasa homolog, CiVH , and other postplasmic components as markers, we found that the postplasm...
Journal Articles
Journal: Development
Development (2005) 132 (3): 459–468.
Published: 1 February 2005
... protein to accumulate during oogenesis, for normal posterior localization of Oskar in later stages of oogenesis and for posterior localization of the Vasa protein during the entire process of pole plasm assembly. There is no evidence for vls being dependent on an upstream factor of the posterior pathway...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4167–4178.
Published: 1 September 2004
...Oona Johnstone; Paul Lasko The DEAD-box RNA helicase Vasa (Vas) is required for germ cell development and function, as well as for embryonic somatic posterior patterning. Vas interacts with the general translation initiation factor eIF5B (cIF2, also known as dIF2), and thus may regulate translation...
Journal Articles
Journal: Development
Development (2002) 129 (3): 661–670.
Published: 1 February 2002
... of a large granule, presumed to be a germ plasm, and its probable inheritance in four primary germ cells (PGCs). Using videomicroscopy, electron microscopy and immunocytochemistry (labelling with anti-Vasa antibodies) we have followed the cycle of aggregation and dispersion of germ plasm and nuage material...
Includes: Multimedia, Supplementary data