... Uterus Müllerian duct Mesenchyme Myofibroblast Cell fate Mouse The Müllerian ducts (or paramesonephric ducts) are paired embryonic structures that give rise to most of the female reproductive tract. They comprise a luminal epithelial cell population, mesenchymal cells that surround...

... and continuation of pregnancy then requires a viable embryo, a receptive uterus and effective molecular communication between the two. But how do the blastocysts survive and remain viable during this period of time, which can be up to a year in some cases? And what are the signals that bring it out of suspended...

... in combination with 3D analysis to identify and quantify dynamic changes to the luminal structure of murine uterus in preparation for implantation. When applied to mouse mutants with known implantation defects, this method detected striking peri-implantation abnormalities in uterine morphology that cannot...

... uterus, and an accumulation of fibrillar-like structures observed by electron microscopy in Vangl2 Lp mutant epithelium suggests that mislocalization of Scrb1 in mutants alters the composition of the apical face of the epithelium. Heterozygous and homozygous Vangl2 Lp mutant postnatal tissues exhibit...

... the axes of the embryo and the uterus at the beginning of gastrulation, a perplexing phenomenon discovered two decades ago. * Author for correspondence (e-mail: jail@uchc.edu ) 3 4 2007 © 2007. 2007 Fgf8 Signaling Alternative splicing Anteroposterior axis Embryo Uterus...

.... 9 -34. Totowa,NJ: Humana Press. DeFeo, V. J. ( 1967 ). Decidualization. In Cellular Biology of the Uterus (ed. R. M. Wynn), pp. 191 -220. New York:Appleton-Century-Crofts. Dimitriadis, E., White, C. A., Jones, R. L. and Salamonsen, L. A. ( 2005 ). Cytokines, chemokines and growth factors...

... grafts grown in adult cycling females. Uterine glands normally appear by 1-2 weeks after birth in situ. In the grafts, a small number of glands appear after 5 weeks of growth under the renal capsule showing an abnormal delay when compared with gland formation in the uterus in situ (data not shown). We...

... Müllerian duct Endocrine disruptor Uterus Estrogen receptor α Diethylstilbestrol (DES) is a synthetic estrogen that was prescribed to prevent miscarriage in pregnant women. It has been estimated that two to four million individuals were exposed to DES during pregnancy from 1946 to 1971( Giusti et...

..., metanephros and fetal gonads. Using, a Lim1 lacZ knock-in allele in mice, we identified a previously unreported urogenital tissue for Lim1 expression, the epithelium of the developing Müllerian duct that gives rise to the oviduct, uterus and upper region of the vagina of the female reproductive tract. Lim1...

... whether HB-EGF plays any role in implantation in hamsters, we examined the expression, regulation and signaling of HB-EGF in the hamster embryo and uterus during the periimplantation period. We demonstrate that both the blastocyst and uterus express HB-EGF during implantation. Hegfl is expressed solely...

... that a short delay in the initial attachment reaction creates a ripple effect propagating developmental anomalies during the subsequent course of pregnancy. *Author for correspondence (e-mail: sdey@kumc.edu ) 26 3 2002 © 2002. 2002 cPLA 2 α implantation uterus embryo pregnancy...

..., and (3) ERα is also necessary for interstitial glandular cell development. Our data also indicate that ERβ exerts some function in ERαKO uterus and vagina. ERαβKO granulosa cells localized within degenerating follicles transform into cells displaying junctions that are unique to testicular Sertoli cells...

...Xuemei Zhao; Wen-ge Ma; Sanjoy K. Das; Sudhansu K. Dey; Bibhash C. Paria ABSTRACT The process of implantation is a ‘two-way’ interaction between the blastocyst and uterus. It has long been suspected that histamine is an important mediator in embryo-uterine interactions during implantation, but its...

...Anna P. Newman; Gwen Z. Acton; Erika Hartwieg; H. Robert Horvitz; Paul W. Sternberg The Caenorhabditis elegans hermaphrodite egg-laying system comprises several tissues, including the uterus and vulva. lin-11 encodes a LIM domain transcription factor needed for certain vulval precursor cells...

...- and motorneurons, in epithelial cells of the uterus and in the excretory system. Loss of lim-6 function affects late events in the differentiation of two classes of GABAergic motorneurons which control rhythmic enteric muscle contraction. lim-6 is required to specify the correct axon morphology of these neurons...

...Gail V. Benson; Hyunjung Lim; B. C. Paria; Ichiro Satokata; Sudhansu K. Dey; Richard L. Maas ABSTRACT The establishment of a receptive uterine environment is critical for embryonic survival and implantation. One gene that is expressed in the uterus during the peri-implantation period in mice...

..., but was central in a smaller, round decidua. During their dissection, instead of splitting along the decidual-uterine junction, MPI-treated deciduae would split along the luminal axis and spill out the embryo. Thus, the formation of a shear zone that separates the decidual mass from the uterus was inhibited...

... in mice with a targeted mutation in the leukemia inhibitory factor (LIF) gene ( Stewart et al., 1992 ). In both cases, oogenesis is normal, but embryos fail to thrive in the mutant uterus. This suggests the possibility of their involvement in a common genetic pathway. The expression pattern of Hoxa...

... possible interactions between the uterine HB-EGF and blastocyst EGF-R very early in the process of implantation, earlier than any other embryo-uterine interactions defined to date at the molecular level. 31 01 1994 © 1994 by Company of Biologists 1994 HB-EGF EGF-R blastocyst uterus...

...JoAnne Julian; Ruth Chiquet-Ehrismann; Harold P. Erickson; Daniel D. Carson ABSTRACT Expression of tenascin, an extracellular matrix protein associated with morphogenetic events and altered states of cellular adhesion, was examined in mouse uterus during the peri-implantation period. A uniform low...