... driving the morphogenesis of mammalian kidney epithelial networks highlight gene sets linked to kidney and cross-organ branching programs. Branching morphogenesis Ureteric bud Tip progenitor RNA-seq Epithelial branching morphogenesis shapes the development of a wide variety of organ...

...Minoru Takasato; Melissa H. Little ABSTRACT The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme...

... that targeted deletion of both the Hdac1 and Hdac2 genes from the ureteric bud (UB) cell lineage of mice causes bilateral renal hypodysplasia. One copy of either Hdac1 or Hdac2 is sufficient to sustain normal renal development. In addition to defective cell proliferation and survival, genome-wide...

...Susan M. Kiefer; Lynn Robbins; Kelly M. Stumpff; Congxing Lin; Liang Ma; Michael Rauchman Development of the metanephric kidney depends on precise control of branching of the ureteric bud. Branching events represent terminal bifurcations that are thought to depend on unique patterns of gene...

...Shuta Ishibe; Anil Karihaloo; Hong Ma; Junhui Zhang; Arnaud Marlier; Mitchihiro Mitobe; Akashi Togawa; Roland Schmitt; Jan Czyczk; Michael Kashgarian; David S. Geller; Snorri S. Thorgeirsson; Lloyd G. Cantley Ureteric bud (UB) branching during kidney development determines the final number...

... to this work These results demonstrate that the ability of the ureteric bud to initiate new branch tips is not restricted to existing tips but is instead distributed widely, at least for the first few days of the bud's existence. This possibility has been suspected recently from time-lapse studies...

...James M. Linton; Gail R. Martin; Louis F. Reichardt Development of the metanephric kidney crucially depends on proper interactions between cells and the surrounding extracellular matrix. For example, we showed previously that in the absence of α8β1 integrin,invasion by the ureteric bud...

...Patrick D. Brophy; Lance Ostrom; Katherine M. Lang; Gregory R. Dressler The outgrowth of the ureteric bud from the posterior nephric duct epithelium and the subsequent invasion of the bud into the metanephric mesenchyme initiate the process of metanephric, or adult kidney, development. The receptor...

...Hiroyuki Sakurai; Kevin T. Bush; Sanjay K. Nigam Branching morphogenesis is central to epithelial organogenesis. In the developing kidney, the epithelial ureteric bud invades the metanephric mesenchyme, which directs the ureteric bud to undergo repeated branching. A soluble factor(s...

...Shankar Srinivas; Zaiqi Wu; Chiann-Mun Chen; Vivette D’Agati; Frank Costantini During kidney development, factors from the metanephric mesenchyme induce the growth and repeated branching of the ureteric bud, which gives rise to the collecting duct system and also induces nephrogenesis. One...

... in the Wolffian duct and WT-1 and GDNF expressions in the metanephric blastema were initially normal in the mutant. The ureteric bud grew and invaded the metanephric mesenchyme where Pax-2 expression was normally induced. Subsequently, however, Pax-2 , c- ret and Lim1 expressions in the ureteric bud and GDNF...

...Anita Schuchardt; Vivette D’Agati; Vassilis Pachnis; Frank Costantini ABSTRACT The c-ret gene encodes a receptor tyrosine kinase that is expressed in the Wolffian duct and ureteric bud of the developing excretory system. Newborn mice homozygous for a mutation in c-ret displayed renal agenesis...