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Keywords: Ureter
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Journal Articles
Journal: Development
Development (2022) 149 (15): dev200522.
Published: 29 July 2022
... that are released from endothelial and epithelial primordia, as well as in response to signals secreted from the SMC progenitors ( Donadon and Santoro, 2021 ; Mack, 2011 ). In the murine ureter, SHH and WNTs have been characterized as epithelial signals from the ureteric bud that maintain UM proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199735.
Published: 17 February 2022
... whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
... crosstalk in the murine ureter. Loss of Fgfr2 in the ureteric epithelium led to reduced proliferation, stratification, intermediate and basal cell differentiation in this tissue, and affected cell survival and smooth muscle cell differentiation in the surrounding mesenchyme. Loss of Fgfr2 impacted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev171827.
Published: 26 November 2018
..., testis; u, ureter; ue, ureteric epithelium; um, ureteric mesenchyme; ut, uterus; vd, vas deferens. Fig. 2. Ureter anomalies in Tbx18cre/+;Tbx2fl/fl;Tbx3fl/fl embryos at E18.5. (A) Morphology of whole urogenital systems of male (column 1 and 2) and female (column 3 and 4) embryos. n≥5, all groups. (B...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1893–1908.
Published: 15 May 2015
... to the bladder ( Fig. 6 G-J; supplementary material ). The ureters are inserted in a stereotypical position in the trigone, where ureteral muscle and bladder muscle intersect to form the anti-reflux valve ( Carpenter et al., 2012 ; Viana et al., 2007 ) ( Fig. 6 K,L). Fig. 6. Morphology of the bladder...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3099–3108.
Published: 1 September 2012
... in the ureteric mesenchyme exhibited hydroureter and hydronephrosis at newborn stages due to functional obstruction of the ureter. Histological analysis revealed that the layer of undifferentiated mesenchymal cells directly adjacent to the ureteric epithelium did not undergo characteristic cell shape changes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3099–3106.
Published: 15 September 2010
..., but it fails to initiate branching despite tip-specific expression of Ret and Wnt11 . The stalk-specific marker Wnt9b and the β-catenin downstream target Axin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical Wnt signaling disrupts ureter branching in this mutant...
Journal Articles
Journal: Development
Development (2010) 137 (5): 755–765.
Published: 1 March 2010
... not shown). Our observation of Six1 expression in the ureteral mesenchyme suggests that it might have a direct role in regulating ureter SMC development. Since the mutant ureters often had a thicker mesenchymal layer, especially in the proximal region ( Fig. 2 ), we tested whether cell...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3301–3310.
Published: 1 October 2008
... interactions during ureter development. Kidney Int. 72 , 1459 -1467. Airik, R., Bussen, M., Singh, M. K., Petry, M. and Kispert,A. ( 2006 ). Tbx18 regulates the development of the ureteral mesenchyme. J. Clin. Invest. 116 , 663 -674. Breiteneder-Geleff, S., Matsui, K., Soleiman, A., Meraner, P...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3763–3769.
Published: 15 October 2007
...-gestation when the ureters move from their primary insertion site in the Wolffian ducts to the trigone, a muscular structure comprising the bladder floor just above the urethra. Precise connections between the ureters and the trigone are crucial for proper function of the ureteral valve mechanism; however...
Journal Articles
Journal: Development
Development (2007) 134 (9): 1799–1807.
Published: 1 May 2007
... into the bladder wall during the descent of the ureteric end. BrdU analysis revealed that cellular proliferation is decreased in the ureteric epithelium of Dlgh1 -/- mice at E12.5. Therefore, it might be possible that elongation of the ureter caused by epithelial proliferation is required for incorporation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (22): 5301–5312.
Published: 15 November 2002
..., ureteric epithelium. We demonstrate that sonic hedgehog is expressed in the ureteric epithelium of the distal, non-branching medullary collecting ducts and continues into the epithelium of the ureter— the urinary outflow tract that connects the kidney with the bladder. Upregulation of patched 1, the sonic...