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Keywords: Unfolded protein response
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (1): 128–138.
Published: 1 January 2017
... development. Loss of p53 suppresses the apoptosis in zar1 mutants and restores oocyte development. zar1 immature ovaries show upregulation of proteins implicated in endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). More importantly, loss of Zar1 causes marked upregulation of zona...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2561–2572.
Published: 15 July 2016
... that exposure of mouse embryos to short-term gestational hypoxia induces the most common types of heart defect. This is mediated by the rapid induction of the unfolded protein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field. Thus, UPR activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1788–1799.
Published: 15 May 2016
... proteins leads to activation of the unfolded protein response pathway and apoptosis. Thus, our data demonstrate that B cell development depends on the proper repression of retrotransposon sequences through Setdb1. Our transcriptional profiling of Setdb1 Mb1 pro-B cells did not reveal dysregulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 558–567.
Published: 1 February 2012
... in the endoplasmic reticulum (ER). Disruption of pcx function resulted in enlargement of the ER that was not attributable to the reduced N signaling activity. In addition, hyper-induction of the unfolded protein response (UPR) by the expression of activated Xbp1 or dominant-negative Heat shock protein cognate 3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3543–3548.
Published: 1 November 2009
..., but not in notochord precursors in the axial mesoderm at early gastrula stage. The genes encoding Xbp1 and Creb3l2 were also activated in the notochord. These two transcription factors are implicated in the activation of secretory pathway genes during the unfolded protein response, where cells react to the stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1745–1749.
Published: 15 May 2008
... in wol mutant embryos triggers endoplasmic reticulum stress and the unfolded protein response (UPR). As a result, phosphorylation of the translation factor eIF2α is increased. We propose a model in which translation of a few maternal mRNAs, including caudal , are particularly sensitive to increased eIF2α...
Includes: Supplementary data