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Keywords: UNC-40
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Neural development
Journal: Development
Development (2021) 148 (11): dev198044.
Published: 10 June 2021
... and muscle promoted ‘ventral targeting’. In response to axotomy, expression of the Netrin receptor UNC-40 was upregulated in the injured neuron in a DAF-16-dependent manner. In contrast, the DAF-2-DAF-16 axis contributed to the age-related decline in Netrin expression in muscle. Therefore, our study revealed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 4070–4080.
Published: 1 October 2013
... in mediating BMP signaling is not well understood. We show that the sole C. elegans DCC/neogenin homolog UNC-40 positively modulates a BMP-like pathway by functioning in the signal-receiving cells at the ligand/receptor level. This function of UNC-40 is independent of its role in netrin-mediated axon guidance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 911–922.
Published: 15 March 2009
... membrane expansion and guided membrane extension. To identify genes required for muscle arm extension, we performed a forward screen for mutants with fewer muscle arms. We isolated 23 mutations in 14 genes, including unc-40/Dcc , which encodes a transmembrane receptor that guides the migration of cells...
Includes: Supplementary data