... pathways that drive stem cell divisions. In a Notch-deficient background, L. brevis -mediated proliferation causes rapid expansion of mutant progenitors, leading to accumulation of large, multi-layered tumors throughout the midgut. Mechanistically, we showed that L. brevis disrupts expression...

... ubiquitin ligase, cause dramatic loss of polarity in imaginal discs accompanied by tumorous proliferation defects. Slmb function is required to restrain apical aPKC activity in a manner that is independent of endolysosomal trafficking and parallel to the Scribble module of junctional scaffolding proteins...

.... , Lehmann R. ( 1992 ). Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos . Genes Dev. 6 , 2312 – 2326 . Betschinger J. , Mechtler K. , Knoblich J. A. ( 2006 ). Asymmetric segregation of the tumor suppressor brat...

... differentiation are coordinated during this transition. Here, we demonstrate that the Arabidopsis thaliana RETINOBLASTOMA-RELATED protein (RBR) ortholog of the animal tumor suppressor retinoblastoma (pRB) not only controls the expression of cell cycle-related genes, but is also required for persistent shut-down...

... neuroepithelia. Mutation of tumor suppressor genes within the pathway, or expression of activated Yorkie, promotes overgrowth of neuroepithelial cells and delays or blocks their differentiation; mutation of yorkie inhibits growth and accelerates differentiation. Neuroblasts and other neural cells, by contrast...

.... 5. GLI1-induced tumorigenesis requires endogenous Gli1 and Gli3 function. (A)Tadpoles injected with human GLI1 and each MO. Arrows show tumors in tadpoles injected with GLI1 and MO-C or MO-2. (B) Sets of tadpoles injected with GLI1 and MO-C or MO-3 showing varying overall deformities...

... tumorous phenotype where the distal proliferative zone increases in size over time, reflecting constitutive GLP-1 activity( Berry et al., 1997 ). In these animals, low GLD-1 levels extend much further proximally than in wild-type( Fig. 2 ). The maximum level,however, still coincides with the transition...

... role in the cerebellum, our findings indicate that SHH signaling unexpectedly controls the development of the three major dorsal brain structures. We also show that a variety of primary human brain tumors and tumor lines consistently express the GLI genes and that cyclopamine, a SHH signaling inhibitor...

... and males have a completely tumorous germ line in which germ cells never leave the mitotic cycle. In glp-1(oz112gf) heterozygotes, germ-line polarity is established correctly, but as adults age, the distal proliferative population expands leading to a late-onset tumorous phenotype. The mutant receptor...

... in a variety of kidney tumors. Yet, little is known about the signals regulating this transient expression pattern in the developing kidney. We have examined the spatial and temporal expression patterns of Pax-2 and the Wilms’ tumor suppresser protein WT1 with specific antibodies in developing mouse kidneys...

...Stefan Mundlos; Jerry Pelletier; André Darveau; Michael Bachmann; Andreas Winterpacht; Bernhard Zabel ABSTRACT The human Wilms’ tumor gene WT1 encodes a putative transcription factor implicated in tumorigenesis and in specifying normal urogenital development. We have studied the distribution of WT1...

... of the cellular retinoic acid-binding protein is the cause of the tumors. These results taken together provide evidence for a role of the cellular retinoic acid-binding protein in development and cell differentiation. The relevance of these findings to the possible role of the cellular retinoic acid-binding...

..., that is also expressed during kidney development and lacks the serine rich region. RNAase protection analysis shows the presence of both PAX8 transcripts in human thyroid, kidney and five Wilms’ tumors. No truncated Pax8 transcripts could be detected in mouse kidney. In situ hybridization to sections of human...