... regulates morphogenesis of the excretory canal (ExCa) cell, a single-cell tube. Subsequent work showed that mammalian CLICs regulate vascular development and angiogenesis, and human CLIC1 can rescue exc-4 mutants, suggesting conserved function in biological tube formation (tubulogenesis) and maintenance...

... KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis . Nat. Commun. 9 , 2815 . 10.1038/s41467-018-05043-5 Yin , W. , Kim , H.-T. , Wang , S. , Gunawan , F. , Li , R. , Buettner , C. , Grohmann , B. , Sengle , G...

... . Curr. Biol.   20 , 1809 - 1818 . 10.1016/j.cub.2010.09.032 Iruela-Arispe , M. L. and Beitel , G. J. ( 2013 ). Tubulogenesis . Development   140 , 2851 - 2855 . 10.1242/dev.070680 Jaffe , A. B. , Kaji , N. , Durgan , J. and Hall , A. ( 2008 ). Cdc42...

... possesses many features that make it an excellent model in which to investigate tubulogenesis, but the cell types and lineage relationships that drive lacrimal gland formation are unclear. Using single-cell sequencing and other molecular tools, we reveal novel cell identities and epithelial lineage dynamics...

...Daniel D. Shaye; Iva Greenwald The C. elegans excretory cell (EC) is a powerful model for tubulogenesis, a conserved process that requires precise cytoskeletal regulation. EXC-6, an ortholog of the disease-associated formin INF2, coordinates cell outgrowth and lumen formation during EC...

...-induced expression of the transcription factor Escargot, which subsequently suppresses ERK signaling. Tubulogenesis Tip cell Cell migration FGF signaling ERK signaling Tubular organs allow for circulation through blood vessels and promote the exchange of gases in the mammalian lung...

... motile epithelial cells whose collective migration drives mammary ductal elongation. Collective cell migration MAPK signaling Branching morphogenesis Epithelial development Tubulogenesis Mammary gland Epithelial tubes are an essential building block of animal organs but the mechanisms...

...Marissa L. Gredler; Ashley W. Seifert; Martin J. Cohn Congenital anomalies frequently occur in organs that undergo tubulogenesis. Hypospadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the penile urethra. Deletion of Fgfr2 or its ligand Fgf10 results...

... their apical membrane domain. Tubulogenesis Drosophila vATPase Tor Apical polarity Summary: Drosophila vATPase and mTOR pathway mutants show impaired terminal cell morphogenesis in trachea, but compensatory mechanisms partially rescue tracheal architecture. © 2015. Published...

... tubulogenesis, single extracellular lumen pockets grow between pairs of cells and eventually fuse into a continuous tube. Here, we show that lumen growth exhibits a lag phase, during which the luminal membranes continue to grow but the expansion of the apical/lateral junction pauses for ∼30 min. Inhibition...

.... 24 9 2013 10 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Apicobasal polarity Epithelial organ development Salivary gland Tubulogenesis Drosophila Epithelial tissues in multicellular organisms are manifested by apicobasal polarity, which is essential...

...Ashley L. Alvers; Sean Ryan; Paul J. Scherz; Jan Huisken; Michel Bagnat The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro...

... regulatory events driving the cell shape changes that produce tubes of specific dimensions. An overview of the current understanding of the molecular processes and physical forces involved in tubulogenesis is presented in this review and the accompanying poster. * Authors for correspondence ( arispe...

...Elsa Denker; Ivana Bočina; Di Jiang Apico-basal polarization is a crucial step in the de novo formation of biological tubes. In Ciona notochord, tubulogenesis occurs in a single file of cells in the absence of cell proliferation. This configuration presents a unique challenge for the formation...

... formation/elongation during kidney tubulogenesis. Kidney development Lumen Tubulogenesis Afadin (Mllt4) Polarity Nectin Cadherin Par complex Formation and elongation of epithelial tubules is essential for the structure and function of many organs. Although general...

... was only recently appreciated and is thought to be limited to basolateral transport. Here, an unbiased RNAi-based tubulogenesis screen identifies a role of clathrin (CHC-1) and its AP-1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine. We show that CHC-1/AP...

... Morphogenesis Tubulogenesis Cells exhibit multiple asymmetries during animal development in response to successive cues that create and change cell polarity. For example, the one-cell C. elegans embryo develops anterior-posterior polarity cued by the sperm-contributed centrosome, but blastomeres...

...: the excretory canal cell, duct and G1 pore. lin-12 and glp-1 / Notch are required to generate the canal cell, which is a source of LIN-3/EGF ligand and physically attaches to the duct during de novo epithelialization and tubulogenesis. Canal cell asymmetry and let-60/Ras signaling influence which of two...

...Bo Dong; Wei Deng; Di Jiang Cell elongation is a fundamental process that allows cells and tissues to adopt new shapes and functions. During notochord tubulogenesis in the ascidian Ciona intestinalis , a dramatic elongation of individual cells takes place that lengthens the notochord...

... polarity, changes in cell shape and cell rearrangements, de novo tubulogenesis and epithelial tubule remodeling. In contrast to the classical epithelial budding and tube extension observed in other organs, a pancreatic branch takes shape as a multi-lumen tubular plexus coordinately extends and remodels...