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Keywords: Tubulogenesis
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Journal Articles
Journal: Development
Development (2021) 148 (13): dev198192.
Published: 6 July 2021
... of mammalian tracheal development, which is distinct from lung in large part, and discusses the generation of tracheal tissues from human pluripotent stem cells. Airway Cartilage Morphogenesis Pluripotent cells Respiratory system Tubulogenesis The epithelium covers the luminal surface...
Journal Articles
Journal: Development
Development (2017) 144 (19): 3511–3520.
Published: 1 October 2017
... ). Tubulogenesis . Development   140 , 2851 - 2855 . 10.1242/dev.070680 Jaffe , A. B. , Kaji , N. , Durgan , J. and Hall , A. ( 2008 ). Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis . J. Cell Biol.   183 , 625 - 633 . 10.1083/jcb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2517–2528.
Published: 1 July 2017
... possesses many features that make it an excellent model in which to investigate tubulogenesis, but the cell types and lineage relationships that drive lacrimal gland formation are unclear. Using single-cell sequencing and other molecular tools, we reveal novel cell identities and epithelial lineage dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4173–4181.
Published: 15 November 2016
...Daniel D. Shaye; Iva Greenwald The C. elegans excretory cell (EC) is a powerful model for tubulogenesis, a conserved process that requires precise cytoskeletal regulation. EXC-6, an ortholog of the disease-associated formin INF2, coordinates cell outgrowth and lumen formation during EC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4261–4271.
Published: 15 November 2016
...-induced expression of the transcription factor Escargot, which subsequently suppresses ERK signaling. Tubulogenesis Tip cell Cell migration FGF signaling ERK signaling Tubular organs allow for circulation through blood vessels and promote the exchange of gases in the mammalian lung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 983–993.
Published: 15 March 2016
... ). Region-specific epithelial cell dynamics during branching morphogenesis . Dev. Dyn.   242 , 1066 - 1077 . 10.1002/dvdy.24000 Huebner , R. J. and Ewald , A. J. ( 2014 ). Cellular foundations of mammary tubulogenesis . Semin. Cell Dev. Biol.   31 , 124 - 131 . 10.1016/j.semcdb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2203–2212.
Published: 15 June 2015
...Marissa L. Gredler; Ashley W. Seifert; Martin J. Cohn Congenital anomalies frequently occur in organs that undergo tubulogenesis. Hypospadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the penile urethra. Deletion of Fgfr2 or its ligand Fgf10 results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (11): 2048–2057.
Published: 1 June 2015
... morphogenesis in trachea, but compensatory mechanisms partially rescue tracheal architecture. Tubulogenesis Drosophila vATPase Tor Apical polarity Tubular networks are essential for nutrient transport, enzyme secretion and ion homeostasis ( Andrew and Ewald, 2010 ; Strilić et al., 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1639–1650.
Published: 1 May 2015
... tubulogenesis, single extracellular lumen pockets grow between pairs of cells and eventually fuse into a continuous tube. Here, we show that lumen growth exhibits a lag phase, during which the luminal membranes continue to grow but the expansion of the apical/lateral junction pauses for ∼30 min. Inhibition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1950–1960.
Published: 1 May 2014
.... Published by The Company of Biologists Ltd 2014 Apicobasal polarity Epithelial organ development Salivary gland Tubulogenesis Drosophila Epithelial tissues in multicellular organisms are manifested by apicobasal polarity, which is essential for their correct form and function ( Laprise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1110–1119.
Published: 1 March 2014
...Ashley L. Alvers; Sean Ryan; Paul J. Scherz; Jan Huisken; Michel Bagnat The formation of a single lumen during tubulogenesis is crucial for the development and function of many organs. Although 3D cell culture models have identified molecular mechanisms controlling lumen formation in vitro...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2851–2855.
Published: 15 July 2013
... regulatory events driving the cell shape changes that produce tubes of specific dimensions. An overview of the current understanding of the molecular processes and physical forces involved in tubulogenesis is presented in this review and the accompanying poster. Lumenal space is also captured to form...
Journal Articles
Journal: Development
Development (2013) 140 (14): 2985–2996.
Published: 15 July 2013
...Elsa Denker; Ivana Bočina; Di Jiang Apico-basal polarization is a crucial step in the de novo formation of biological tubes. In Ciona notochord, tubulogenesis occurs in a single file of cells in the absence of cell proliferation. This configuration presents a unique challenge for the formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1774–1784.
Published: 15 April 2013
... formation/elongation during kidney tubulogenesis. * Author for correspondence ( denise.marciano@utsouthwestern.edu ) Competing interests statement The authors declare no competing financial interests. 5 2 2013 © 2013. Published by The Company of Biologists Ltd 2013 Kidney...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2071–2083.
Published: 1 June 2012
... was only recently appreciated and is thought to be limited to basolateral transport. Here, an unbiased RNAi-based tubulogenesis screen identifies a role of clathrin (CHC-1) and its AP-1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine. We show that CHC-1/AP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (11): 2050–2060.
Published: 1 June 2012
... mesenchymal to epithelial transition (MET) (reviewed by Chaffer et al., 2007 ). Epithelial polarity Laminin Mesenchymal to epithelial transition Morphogenesis Tubulogenesis © 2012. 19 3 2012 Competing interests statement The authors declare no competing financial...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3545–3555.
Published: 15 August 2011
...: the excretory canal cell, duct and G1 pore. lin-12 and glp-1 / Notch are required to generate the canal cell, which is a source of LIN-3/EGF ligand and physically attaches to the duct during de novo epithelialization and tubulogenesis. Canal cell asymmetry and let-60/Ras signaling influence which of two...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1631–1641.
Published: 15 April 2011
...Bo Dong; Wei Deng; Di Jiang Cell elongation is a fundamental process that allows cells and tissues to adopt new shapes and functions. During notochord tubulogenesis in the ascidian Ciona intestinalis , a dramatic elongation of individual cells takes place that lengthens the notochord...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (24): 4295–4305.
Published: 15 December 2010
... polarity, changes in cell shape and cell rearrangements, de novo tubulogenesis and epithelial tubule remodeling. In contrast to the classical epithelial budding and tube extension observed in other organs, a pancreatic branch takes shape as a multi-lumen tubular plexus coordinately extends and remodels...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (18): 3121–3129.
Published: 15 September 2009
...Mili Jeon; Kai Zinn The formation of epithelial tubes with defined shapes and sizes is essential for organ development. We describe a unique tracheal tubulogenesis phenotype caused by loss of both Drosophila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D. Ptp4E is the only widely...
Includes: Supplementary data