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Keywords: Trophoblast
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200115.
Published: 31 March 2022
...Viju Vijayan Pillai; Tiffany G. Kei; Shailesh Gurung; Moubani Das; Luiz G. B. Siqueira; Soon Hon Cheong; Peter J. Hansen; Vimal Selvaraj ABSTRACT Exponential proliferation of trophoblast stem cells (TSC) is crucial in Ruminantia to maximize numerical access to caruncles, the restricted uterine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199840.
Published: 12 January 2022
... trajectories: the villous or extravillous pathways. CTB committed to the villous pathway fuse with neighboring CTB to form the outer multinucleated syncytiotrophoblast (SCT), whereas CTB committed to the extravillous pathway differentiate into invasive extravillous trophoblasts (EVT). Unfortunately, little...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev199811.
Published: 4 January 2022
... work is properly attributed. Highlighted Article: Imprinting at Igf2-H19 ICR1 regulates endocrine cell formation and function via sexually-dimorphic changes in Pi3k-Akt and Mapk signalling in the mouse. Insulin-like growth factor Placenta Hormones Endocrine cells Trophoblast...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (20): dev199626.
Published: 19 October 2021
... the uterine surface, these progenitors assume a different fate, becoming cancer-like cells that invade its lining and blood vessels. The latter process physically connects the placenta to the mother and shunts uterine blood to the syncytiotrophoblasts. Isolation of trophoblast subtypes is technically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev197673.
Published: 27 April 2021
... fetal tissues; however, there is no evidence of a placental function controlled by the LZ clock. Here, we demonstrate that specifically the trophoblast layer of the LZ harbors an already functional clock by late gestation, able to regulate in a circadian manner the expression and activity...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev190371.
Published: 3 July 2020
...Hatice O. Ozguldez; Rui Fan; Ivan Bedzhov ABSTRACT The ways in which placental defects affect embryonic development are largely overlooked because of the lack of a trophoblast-specific approach for conditional gene ablation. To tackle this, we have established a simple, fast and efficient method...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (2): dev181263.
Published: 23 January 2020
...Jenna Treissman; Victor Yuan; Jennet Baltayeva; Hoa T. Le; Barbara Castellana; Wendy P. Robinson; Alexander G. Beristain ABSTRACT Early placental development and the establishment of the invasive trophoblast lineage take place within a low oxygen environment. However, conflicting and inconsistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev163428.
Published: 27 November 2019
... the morphological, molecular and functional aspects of human placental formation, with a focus on the defining cell of the placenta – the trophoblast. * Author for correspondence ( myt25@cam.ac.uk ) Competing interests The authors declare no competing or financial interests. © 2019. Published...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (11): dev172205.
Published: 10 June 2019
... 4 days after conception. We show female-specific effects on trophoblast differentiation, embryo-uterine communication, and formation of the placental vasculature, resulting in markedly reduced placental volume at embryonic day 15. Both sexes exhibited reduced trophectoderm pluripotency and global...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (20): 3731–3743.
Published: 15 October 2017
... to the trophoblast lineage, where it remains highly expressed until birth. Deletion of the miR-290 cluster gene ( Mirc5 ) results in reduced trophoblast progenitor cell proliferation and a reduced DNA content in endoreduplicating trophoblast giant cells. The resulting placenta is reduced in size. In addition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (15): 2784–2797.
Published: 1 August 2017
... was substantially compromised upon paternal transmission, allele-specific RNA-seq in the trophoblast revealed that Xist CAGΔ5′ RNA still retained some silencing ability. Furthermore, the failure of imprinted X inactivation had more significant impacts than expected on genome-wide gene expression. It is likely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3650–3660.
Published: 15 October 2016
...Paulina Anna Latos; Myriam Hemberger Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have shown how signalling cascades integrate with transcription factor circuits...
Journal Articles
Journal: Development
Development (2016) 143 (5): 787–798.
Published: 1 March 2016
.... To investigate the requirement of TFAP2C in later placental development, deletion of TFAP2C was induced throughout extra-embryonic ectoderm at E6.5, leading to severe placental abnormalities caused by reduced trophoblast population and resulting in embryonic retardation by E8.5. Deletion of TFAP2C in TPBPA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 3965–3976.
Published: 1 October 2013
... development. Its main functional component is the trophoblast, which is derived from extra-embryonic ectoderm. Little is known about early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model system. Human embryonic stem cells (hESCs) differentiate into functional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 965–975.
Published: 1 March 2013
...Stephen Frankenberg; Geoff Shaw; Claudia Freyer; Andrew J. Pask; Marilyn B. Renfree Early cell lineage specification in eutherian mammals results in the formation of a pluripotent inner cell mass (ICM) and trophoblast. By contrast, marsupials have no ICM. Here, we present the first molecular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2987–2998.
Published: 15 July 2011
...Nathan M. Hunkapiller; Malgorzata Gasperowicz; Mirhan Kapidzic; Vicki Plaks; Emin Maltepe; Jan Kitajewski; Jay C. Cross; Susan J. Fisher Placental trophoblasts (TBs) invade and remodel uterine vessels with an arterial bias. This process, which involves vascular mimicry, re-routes maternal blood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2083–2091.
Published: 15 June 2008
...David G. Simmons; David R. C. Natale; Valerie Begay; Martha Hughes; Achim Leutz; James C. Cross The labyrinth of the rodent placenta contains villi that are the site of nutrient exchange between mother and fetus. They are covered by three trophoblast cell types that separate the maternal blood...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1597–1607.
Published: 15 April 2006
... by the aggregation of NT and tetraploid embryos reveal no growth abnormalities at gastrulation. These studies indicate that the trophoblast cell lineage is the primary source of these defects. These embryological studies provide a solid basis for understanding reprogramming errors in NT embryos. In addition...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1059–1068.
Published: 15 March 2006
...Pantelis Georgiades; Janet Rossant Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted to the trophoblast in early...
Journal Articles
Journal: Development
Development (2006) 133 (4): 751–759.
Published: 15 February 2006
..., a human pregnancy disorder associated with poor trophoblast differentiation and survival. This growth factor protects against apoptosis during stress,suggesting a role in trophoblast survival in the relatively low O 2 (∼2%) environment of the first trimester conceptus. Using a well-characterized human...