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Keywords: Trithorax group
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Journal Articles
Journal: Development
Development (2018) 145 (7): dev163808.
Published: 5 April 2018
...Sigrun Schmähling; Arno Meiler; Yoonjung Lee; Arif Mohammed; Katja Finkl; Katharina Tauscher; Lars Israel; Marc Wirth; Julia Philippou-Massier; Helmut Blum; Bianca Habermann; Axel Imhof; Ji-Joon Song; Jürg Müller ABSTRACT The Drosophila Ash1 protein is a trithorax-group (trxG) regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2876–2887.
Published: 1 September 2015
... are silenced is a fundamental focus in biology. The Polycomb and Trithorax group chromatin proteins play important roles promoting the stable and heritable repression and activation of gene expression, respectively. These proteins, which are conserved across metazoans, modulate post-translational modifications...
Journal Articles
Journal: Development
Development (2014) 141 (3): 526–537.
Published: 1 February 2014
... and a key product of Trithorax group action. Here, we show that Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells. Mll2 is bound to bivalent promoters but also to most active promoters, which do...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4182–4192.
Published: 15 October 2013
...Kristel M. Dorighi; John W. Tamkun Members of the Polycomb group of repressors and trithorax group of activators maintain heritable states of transcription by modifying nucleosomal histones or remodeling chromatin. Although tremendous progress has been made toward defining the biochemical...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (24): 4582–4590.
Published: 15 December 2012
.... Here, we report that GAGA factor associates with the Polybromo-associated Brm (PBAP) remodeling complex, which consists of many Trithorax group proteins, and recruits this complex to chromatin boundaries d1 (which is downstream of w ), the Fab-7 DNase-hypersensitive site (HS) 1 of Abd-B and the bxd...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 4131–4139.
Published: 15 December 2008
... properties of Polycomb-group proteins, whereas their activities are generally opposed by the trithorax group. Both groups modify chromatin structure, but how their opposing activities are targeted to allow differential maintenance remains a mystery. Here, we identify a strong pairing-sensitive silencing (PSS...
Journal Articles
Journal: Development
Development (2005) 132 (16): 3753–3765.
Published: 15 August 2005
..., and the Polycomb and trithorax groups of chromatin regulators. Functional tests revealed that transdetermination was significantly affected in mutants for lama and seven different PcG and trxG genes. These results validate our methods for expression profiling as a way to analyze developmental programs, and show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (2): 343–354.
Published: 15 January 2003
...Luis Gutiérrez; Mario Zurita; James A. Kennison; Martha Vázquez The trithorax group genes are required for positive regulation of homeotic gene function. The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex. We...
Journal Articles
Journal: Development
Development (2002) 129 (6): 1339–1343.
Published: 15 March 2002
... of the two maintenance systems are initially targeted to the correct genes. Zeste and GAGA are sequence-specific DNA-binding proteins previously shown to be Trithorax group activators of the homeotic gene Ultrabithorax ( Ubx ). We demonstrate that Zeste and GAGA DNA-binding sites at the proximal promoter...