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Keywords: Transplantation
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Journal Articles
Journal: Development
Development (2024) 151 (7): dev202067.
Published: 2 April 2024
... highlights promising clinical results and discusses challenges associated with clinical translation. Human pluripotent stem cells Cell therapy Transplantation Clinical trial ATMP Horizon 2020 Framework Programme http://dx.doi.org/10.13039/100010661 874758 Novo Nordisk...
Journal Articles
Journal: Development
Development (2022) 149 (8): dev200139.
Published: 24 January 2022
... reduced the number of B1a cells, MZBs, ILC2s and Tregs, both in situ and upon transplantation, indicating an intrinsic and essential role for IL7Rα. Surprisingly, reciprocal transplants of wild-type HSCs showed that an IL7Rα −/− environment selectively impaired reconstitution of TLCs when compared...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1375–1386.
Published: 1 April 2015
... demonstrated by the induction of the striatal transcription factors CTIP2, GSX2 and FOXP2. Crucially, these human LGE progenitors readily differentiate into postmitotic neurons expressing the striatal projection neuron signature marker DARPP32, both in culture and following transplantation in the adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (9): 1443–1452.
Published: 1 May 2009
.... 2009 Glia Myelination Neuron-glial switch Purmorphamine Transplantation Oligodendrocytes, the myelinating glia in the central nervous system (CNS),are differentiated chiefly from neuroepithelial (NE) cells in the ventral neural tube. These NE cells express the helix-loop-helix...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (10): 1853–1859.
Published: 15 May 2007
... and generated offspring following spermatogonial transplantation into the testes of infertile recipient mice, indicating that they are functionally normal. These results demonstrate that activation of the PI3K-Akt pathway plays a central role in the self-renewal division of spermatogonial stem cells. 13 3...
Journal Articles
Journal: Development
Development (2007) 134 (3): 449–454.
Published: 1 February 2007
... is sufficient to induce a fully functional testicular soma capable of supporting complete spermatogenesis in the XX body. Here, we demonstrate that the testicular somatic environment of XX/Sry males is defective in supporting the later phases of spermatogenesis. Spermatogonial transplantation analyses using XX...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (18): 3671–3681.
Published: 15 September 2006
... a single progenitor to theoretically form sufficient cells for∼4×10 7 adult brains. AHNPs longitudinally maintain the ability to generate both glial and neuronal cell types in vivo and in vitro,and are amenable to genetic modification and transplantation. These findings suggest an unprecedented degree...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (20): 4955–4962.
Published: 15 October 2003
...Anne Holz; Barbara Bossinger; Thomas Strasser; Wilfried Janning; Robert Klapper As in many other organisms, the blood of Drosophila consists of several types of hemocytes, which originate from the mesoderm. By lineage analyses of transplanted cells, we specified two separate anlagen that give rise...
Journal Articles
Journal: Development
Development (2002) 129 (2): 433–442.
Published: 15 January 2002
...-institute.org ) 24 10 2001 © 2002. 2002 Neural crest Hindbrain Segmentation Cell migration Cell death Head patterning Mouse Chick Transplantation The cranial neural crest is a pluripotent mesenchymal population that plays a critical role in construction of the vertebrate head...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2517–2524.
Published: 1 July 2001
...Robert Klapper; Sandra Heuser; Thomas Strasser; Wilfried Janning In order to reveal syncytia within the visceral musculature of Drosophila melanogaster , we have combined the GAL4/UAS system with the single-cell transplantation technique. After transplantation of single cells from UAS-GFP donor...
Journal Articles
Journal: Development
Development (1999) 126 (12): 2643–2651.
Published: 15 June 1999
... from an early stage (Stainier,D. Y. R., Weinstein, B. M., Detrich, H. W. R., Zon, L. I. and Fishman, M. C. (1995) Development 121, 3141-3150). cloche mutants lack endocardium, as well as head and trunk endothelium, and nearly all blood cells. Cell transplantation studies have revealed...
Journal Articles
Journal: Development
Development (1999) 126 (5): 1031–1040.
Published: 1 March 1999
...@sci.himeji-tech.ac.jp ) 27 10 1999 27 11 1999 © 1999 by Company of Biologists 1999 Regeneration Blastema formation Dorsoventral interaction Planarian Chimera Transplantation The planarian is remarkable in its ability to regenerate. Even a small fragment cut from...
Journal Articles
Journal: Development
Development (1998) 125 (22): 4507–4520.
Published: 15 November 1998
... Mesothelium Mouse Placenta Transplantation Vasculogenesis Yolk sac The chorioallantoic placenta of eutherian mammals is critical for fetal development and growth during gestation. While much effort has been devoted to investigating the roles of the mature placenta, study of differentiation of two...
Journal Articles
Journal: Development
Development (1998) 125 (10): 1921–1930.
Published: 15 May 1998
...Edith C. Kordon; Gilbert H. Smith ABSTRACT Any epithelial portion of a normal mouse mammary gland can reproduce an entire functional gland when transplanted into an epithelium-free mammary fat pad. Mouse mammary hyperplasias and tumors are clonal dominant populations and probably represent...
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (24): 5087–5096.
Published: 15 December 1997
..., which is expressed in the ventricular zone, in cortical development. Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors. When late-born Sey/Sey precursors were transplanted into wild-type embryonic rat cortex...
Journal Articles
Journal: Development
Development (1997) 124 (24): 4949–4958.
Published: 15 December 1997
... by transplantation of midline cells as well as by homotopic expression of single-minded , the master gene for midline development. Furthermore, ectopic midline cells are able to induce enhanced expression of some lateral CNS cell markers. We thus conclude that the CNS midline plays an important role...