..., depletion of eef1a1l2 in nanog mutant females effectively rescued the elevated translational activity in oocytes, oogenesis defects and embryonic defects of M nanog embryos. Thus, our study demonstrates that maternal Nanog regulates oogenesis and early embryogenesis through translational control of maternal...

... Oogenesis p53 Zebrafish Translational control ER stress Unfolded protein response Apoptosis Sex differentiation In contrast to spermatogenesis, oogenesis is associated with increasing cell volume and accumulating maternal molecules such as RNAs and proteins, which are essential for oogenesis...

... in the male Drosophila germline is regulated by two interacting proteins, Rbp4 and Fest. Drosophila Spermatogenesis Meiosis Cyclin B Translational control Meiosis, the pair of specialized cell divisions required to convert germline diploid progenitor cells into haploid gametes...

...@enders.tch.harvard.edu ) Competing interests statement L.I.Z. is a founder and stock holder of Fate, Inc. and a scientific advisor for Stemgent. 25 3 2013 © 2013. Published by The Company of Biologists Ltd 2013 RAS Embryogenesis Rhabdomyosarcoma Translational control Zebrafish...

... Translational control Fertility Translational control plays a crucial role during development when transcription is quiescent or when asymmetric localization of proteins needs to be established, such as in early embryogenesis, neurogenesis and oogenesis ( Kong and Lasko, 2012 ; Sonenberg...

... interests. 10 8 2011 © 2011. Sox6 Translational control miR-499 ( mir499 ) Muscle fibre type Zebrafish Prdm1 During skeletal myogenesis in vertebrates, mesodermally derived muscle progenitor cells give rise to myoblasts that in turn differentiate into either slow...

... beyond transport at the nuclear pore to include mRNA regulation in the cytoplasm. C. elegans Nup98 P granule Germline Nucleoporin Translational control Germ cells contain unique cytoplasmic organelles called germ granules ( Saffman and Lasko, 1999 ). Germ granules are rich in RNA...

... specifically required for different steps of oogenesis. © 2008. 2008 Cytoplasmic polyadenylation Drosophila GLD-2 Meiosis Metaphase I Translational control * Author for correspondence (e-mail: Martine.Simonelig@igh.cnrs.fr ) 8 4 2008 In many species, the oocyte and early...

... is the earliest known molecular event specific to the germline founder cell P 4 . Cis-elements in nos-2 3′UTR have been shown to mediate translational control; however, the trans-acting proteins are not known. Here, we provide evidence that four maternal RNA-binding proteins, OMA-1, OMA-2, MEX-3 and SPN-4, bind...

...Catherine C. Baker; Margaret T. Fuller Translational control is crucial for proper timing of developmental events that take place in the absence of transcription, as in meiotic activation in oocytes, early embryogenesis in many organisms, and spermatogenesis. Here we show that a novel form...

... phenotypes, i.e. progressive oocyte loss and infertility, elicited by the knockdown of CPEB in oocytes resemble those of the human premature ovarian failure syndrome. CPEB Oogenesis Translational control Polyadenylation Mouse * Author for correspondence (e-mail: joel.richter@umassmed.edu...

... activation of nanos mRNA localized at the posterior pole. Two mechanisms of nanos translational repression have been described, at the initiation step and after this step. Here we identify a novel level of nanos translational control. We show that the Smaug protein bound to the nanos 3′ UTR recruits...

.... † Author for correspondence (e-mail: ahajnal@zool.unizh.ch ) * These authors contributed equally to this work 15 6 2006 © 2006. 2006 Caenorhabditis elegans Vulva Pumilio Translational control Signal transduction The spatial and temporal regulation of gene expression...

...Kevin M. Forrest; Ira E. Clark; Roshan A. Jain; Elizabeth R. Gavis Translational control of gene expression plays a fundamental role in the early development of many organisms. In Drosophila , selective translation of nanos mRNA localized to the germ plasm at the posterior of the embryo, together...

...Darcy Mootz; Diana M. Ho; Craig P. Hunter Translational control is an essential mechanism of gene control utilized throughout development, yet the molecular mechanisms underlying translational activation and repression are poorly understood. We have investigated the translational control of the C...

... in translational regulation. These factors should constitute a network; therefore, the identification and characterization of other regulators and target mRNAs is needed to understand the nature of the translational control of maternal mRNA. We thank R. Barstead for the two-hybrid cDNA library, J. Kimble...

... of the Prm1 3′ UTR should confer Prm1 -like translational control on the PMP transgene, and thus delay translation of MSY4 until the elongated spermatid stage ( Fig. 1 B). The presence of the hGH 3′ UTR in the PMH transgene is expected to relieve this repression and allow translation in round...

...Ira E. Clark; Krista C. Dobi; Heather K. Duchow; Anna N. Vlasak; Elizabeth R. Gavis Translational repression of maternal nanos ( nos ) mRNA by a cis -acting Translational Control Element (TCE) in the nos 3′UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through...

... recruit different partners to specifically regulate distinct mRNAs. *Author for correspondence (e-mail: egottlieb@mail.utexas.edu ) 1 3 2002 © 2002. 2002 Gene regulation Puf proteins Translational control Drosophila anterior patterning RNA-binding proteins 3′UTR Post...

... to cell polarity and spindle alignment in early C. elegans embryos. Cell 83 , 743 -752. Evans, T. C., Crittenden, S. L., Kodoyianni, V. and Kimble, J. ( 1994 ). Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo. Cell 77 , 183 -194. Fire...