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Keywords: Translation
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (22): dev201709.
Published: 27 November 2023
... period termed meiotic prophase. In Drosophila males, meiotic prophase lasts 3.5 days, during which spermatocytes upregulate over 1800 genes and grow 25-fold. Previous work has shown that the cell cycle regulator Cyclin B (CycB) is subject to translational repression in immature spermatocytes, mediated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (21): dev201773.
Published: 18 October 2023
...–NOT complex may target the CPE sequence to suppress translational activation of CPE-containing mRNAs by shortening their poly(A) tails. Fig. 4. Genes with CPE in their 3′UTRs are translationally activated in CNOT7&8 KO oocytes. (A) Enrichment analysis of cis-regulatory elements on mRNA 3′UTRs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (22): dev200930.
Published: 18 November 2022
... migration processes. Therefore, local translation of ERM-1 could be sensitive to incoming signals or developmental needs. As an example of this concept, the mRNA encoding PCNT (pericentrin) in human cells and zebrafish embryos localizes co-translationally to dividing centrosomes during early mitosis...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (21): dev200900.
Published: 24 October 2022
... on translationally repressed mRNAs with short polyA-tails ( Kim and Richter, 2007 ). This suggests that mRNAs bound by the Zar1l RNP could potentially be controlled by regulated polyadenylation during later developmental states. In addition to the aforementioned proteins, many of the identified Zar1l interaction...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199560.
Published: 29 October 2021
...Mansour Aboelenain; Karen Schindler ABSTRACT Mammalian oocytes are transcriptionally quiescent, and meiosis and early embryonic divisions rely on translation of stored maternal mRNAs. Activation of these mRNAs is mediated by polyadenylation. Cytoplasmic polyadenylation binding element 1 (CPEB1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev196121.
Published: 15 April 2021
... translationally repressed. In addition to the highest number of SunTag-hb mRNA translation sites being detected at nc13, analysis of the number of ribosomes translating the mRNAs in nc13 and 14 reveals that SunTag-hb mRNAs are more heavily translated in nc13. In nc14, the low number of mRNAs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev156117.
Published: 8 January 2018
... Translation Parkinson's disease (PD) is a debilitating neurodegenerative movement disorder resulting from progressive loss of dopaminergic (DA) neurons in the midbrain. The relatively focal degeneration makes it a good candidate for cell-based therapies. Since the first clinical trials using fetal...
Journal Articles
Journal: Development
Development (2017) 144 (7): 1201–1210.
Published: 1 April 2017
...Nathalie Oulhen; S. Zachary Swartz; Jessica Laird; Alexandra Mascaro; Gary M. Wessel Stem cells in animals often exhibit a slow cell cycle and/or low transcriptional activity referred to as quiescence. Here, we report that the translational activity in the primordial germ cells (PGCs) of the sea...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (11): 1960–1970.
Published: 1 June 2015
... is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 3951–3963.
Published: 1 October 2013
... of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation...
Journal Articles
Journal: Development
Development (2012) 139 (9): 1547–1556.
Published: 1 May 2012
... differentiation and partners with the serine/threonine kinase Fused to reduce levels of the Dpp receptor Tkv in cystoblasts ( Casanueva and Ferguson, 2004 ; Xia et al., 2010 ). The TRIM-NHL domain protein Brat also functions in cystoblasts, serving to translationally repress Mad expression ( Harris et al., 2011...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1509–1521.
Published: 15 April 2012
... as a positive regulator of target gene expression ( Kaye et al., 2009 ). GLD-1 is also a translational repressor ( Jan et al., 1999 ) with many target mRNAs ( Wright et al., 2010 ) and roles in both sex determination and meiotic progression ( Francis et al., 1995b ). gld-1 is itself both positively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 689–698.
Published: 15 February 2009
...Solenn Patalano; Marija Mihailovich; Yaiza Belacortu; Nuria Paricio; Fátima Gebauer Dosage compensation in Drosophila melanogaster involves the assembly of the MSL-2-containing dosage compensation complex (DCC) on the single X chromosome of male flies. Translational repression of msl-2 mRNA blocks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1547–1557.
Published: 15 April 2008
...Charles R. Tessier; Kendal Broadie Fragile X Syndrome (FraX) is a broad-spectrum neurological disorder with symptoms ranging from hyperexcitability to mental retardation and autism. Loss of the fragile X mental retardation 1 ( fmr1 ) gene product,the mRNA-binding translational regulator FMRP...
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (17): 4167–4178.
Published: 1 September 2004
... to a meiotic checkpoint, activated by a delay in DNA double-strand break (DSB) repair during oogenesis, Vas is post-translationally modified, and this corresponds to a downregulation in Grk protein accumulation( Ghabrial and Schüpbach,1999 ). In previous work, we identified a translation factor dIF2, now...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2717–2728.
Published: 15 June 2003
... of Hoxb4 expression is restricted by regulating transcript stability in the paraxial mesoderm and by selective translation and/or degradation of protein in the neural tube. Moreover, the absence of Hoxb4 3′-untranslated sequences from transgene transcripts leads to inappropriate expression of some Hoxb4...
Journal Articles
Journal: Development
Development (2003) 130 (12): 2623–2632.
Published: 15 June 2003
...Veronica A. Marin; Thomas C. Evans In C. elegans , the Notch receptor GLP-1 is localized within the germline and early embryo by translational control of glp-1 mRNA. RNA elements in the glp-1 3′untranslated region (3′ UTR) are necessary for repression of glp-1 translation in germ cells...