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Keywords: Transgenesis
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Journal Articles
Journal: Development
Development (2014) 141 (3): 715–724.
Published: 1 February 2014
...Jennifer Anne Roberts; Irene Miguel-Escalada; Katherine Joan Slovik; Kathleen Theodora Walsh; Yavor Hadzhiev; Remo Sanges; Elia Stupka; Elizabeth Kate Marsh; Jorune Balciuniene; Darius Balciunas; Ferenc Müller Zebrafish transgenesis is increasingly popular owing to the optical transparency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (24): 5451–5458.
Published: 15 December 2011
... of biological systems, the ability to move transgenesis experiments efficiently between organisms becomes essential. DNA constructions used in transgenesis usually contain four elements, including sequences that facilitate transgene genome integration, a selectable marker and promoter elements driving a coding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4801–4812.
Published: 1 November 2011
... in mouse and human. Disruption or elimination of any one of these lineages results in early embryonic lethality. However, the factors that regulate the co-emergence of these lineages from the mesodermal progenitor pools are incompletely defined. Transgenesis Er71 ( Etv2 ) knockout Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (19): 4327–4332.
Published: 1 October 2011
... recapitulate endogenous expression patterns and levels is often difficult and using large genomic DNA fragments, such as bacterial artificial chromosomes (BACs), makes the process of transgenesis less reliable. Here we provide a detailed protocol that allows for BAC selection and subsequent rapid modification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2625–2630.
Published: 15 June 2011
... they offer to address biological questions of broad interest. Candidate gene approaches have, until now, been the main avenue for applying knowledge gained in established models to other species of interest, but these approaches are biased and incomplete. The establishment of transgenesis in new species...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 169–177.
Published: 1 January 2011
.... , Mishina M. ( 2004 ). A transposon-mediated gene trap approach identifies developmentally regulated genes in zebrafish . Dev. Cell 7 , 133 - 144 . Kikuta H. , Kawakami K. ( 2009 ). Transient and stable transgenesis using tol2 transposon vectors . Methods Mol. Biol. 546 , 69...
Journal Articles
Journal: Development
Development (2010) 137 (11): 1919–1929.
Published: 1 June 2010
... Heart Xenopus laevis Xenopus tropicalis SMAD1 SMAD4 T-box BMP Zebrafish Transgenesis A series of clinical studies has provided direct evidence of a role for T-box genes in heart development and human disease, as mutations in at least three T-box genes, TBX1, TBX5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2883–2892.
Published: 1 September 2009
... for organogenesis, knowledge of the regulation of Wt1 expression is scarce. Here, we have used transgenesis in zebrafish harboring two wt1 genes, wt1a and wt1b , in order to define regulatory elements that drive wt1 expression in the kidney. Stable transgenic lines with approximately 30 kb of the upstream genomic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 987–997.
Published: 1 March 2005
... Nkx2-5 Smooth muscle Transgenesis Knowledge of the regulatory mechanisms underlying cardiac development is essential for understanding the molecular basis of congenital heart defects. During embryonic heart development, differentiation of cardiac muscle is regulated by interactions between...
Journal Articles
Journal: Development
Development (2003) 130 (18): 4307–4323.
Published: 15 September 2003
..., the potentialities and fate of MH precursors in these conditions have not been directly determined. To follow the dynamics of MH maintenance in vivo, we used artificial chromosome transgenesis in zebrafish to construct lines where egfp transcription is driven by the complete set of regulatory elements of her5...
Journal Articles
Journal: Development
Development (2002) 129 (13): 3227–3239.
Published: 1 July 2002
... ). Modification of bacterial artificial chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA 95 , 5121 -5126. Joyner, A. L. and Martin, G. R. ( 1987 ). En-1 and En-2, two mouse genes with sequence homology to the Drosophila...
Journal Articles
Journal: Development
Development (2001) 128 (20): 3995–4010.
Published: 15 October 2001
... 2001 © 2001. 2001 Lens Differentiation TGFβ TGFβ receptors Transgenesis Mouse Previous studies have provided evidence that members of the fibroblast growth factor (FGF) and transforming growth factor β (TGFβ) growth factor families play important roles in lens biology. Numerous...