... , K. A. , Kurial , S. N. T. , Hsu , B. Y. , Cast , A. E. , Donnelly , B. , Karns , R. A. , Chen , F. , Rezvani , M. , Luu , H. Y. et al. ( 2018 ). De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation . Nature 557 , 247...

... of pdx1 expression. We found four hit compounds and validated their efficacy at different stages of pancreas development. Notably, valproic acid treatment increased pancreatic endoderm formation, while inhibition of TGFβ signaling led to α-cell to β-cell transdifferentiation. HC toxin, another HDAC...

... of a root can morph in the span of a couple of cell division cycles into those of a shoot, and back, through transdifferentiation. * These authors are co-first authors ‡ These authors are co-senior authors § Authors for correspondence ( pierre.hilson@inra.fr ; marco.da-costa@inra.fr...

.... Acad. Sci. USA   97 , 4052 - 4057 . 10.1073/pnas.060037197 Zhou , X. , von der Mark , K. , Henry , S. , Norton , W. , Adams , H. and de Crombrugghe , B. ( 2014 ). Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal...

... direct conversion can shed light on unsolved questions in developmental biology. Conversion Direct reprogramming Neurogenesis Neuron Neuronal subtype Transdifferentiation Transcription factor During development, specific cell fates are programmed by extrinsic and intrinsic cues...

... to transcriptional activation in groups of prosensory cells, and that highly conserved sites for Hes/Hey repressor binding in the Atoh1 promoter are needed to select the hair cell and supporting cell fate. During perinatal supporting cell transdifferentiation, which is a model of hair cell regeneration, we show...

... and transdifferentiation, among other topics. In this meeting, translational research on stem cells for disease modeling and therapy was also presented. This Meeting Review describes key themes and selected findings, providing a timely update on this fast-moving area of research. * Author for correspondence ( limd...

...Lihua Ye; Morgan A. Robertson; Daniel Hesselson; Didier Y. R. Stainier; Ryan M. Anderson The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery...

... be harnessed to promote maturation of neurons obtained by transdifferentiation of human cells in vitro . * These authors contributed equally to this work ‡ Author for correspondence ( ap113@cam.ac.uk ) Competing interests The authors declare no competing financial interests. 22 11...

... molecular markers parallels loss of markers for the original differentiated pharynx state; hence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferentiation process. Based on high-resolution morphological characteristics, the transdifferentiated cells become...

... by which reprogramming may be experimentally performed: nuclear transfer to eggs or oocytes, cell fusion, extract treatment, direct reprogramming to pluripotency and transdifferentiation. * Author for correspondence ( rph32@cam.ac.uk ) Competing interests statement The authors declare...

... transdifferentiate toward a pigment cell fate. ( A-B ″′) Magnified views of a wild-type ommatidium (A-A″′, GFP not shown) and an Abl mutant ommatidium (B-B″′, lack of GFP) stained with E(spl) (red, A″,B″) and So (blue, A″′,B″′) antibodies and marked by cell types. E(spl) antibody stains secondary and tertiary...

...-to-PDA transdifferentiation ( Fig. 1E ; see Materials and methods). We focused on unc-3(e151) , the reference allele that has been described as a null allele ( Prasad et al., 1998 ) and which affects Y-to-PDA conversion with high penetrance ( Fig. 1D-F ). How differentiated cells change identity...

... that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa . Sodium...

...-associated insulin + cells. We found that hyperplastic ductal cells arose largely from acinar cells that changed their cell fate, or transdifferentiated, into ductal cells. However, insulin + cells adjacent to acinar-derived ductal cells arose from pre-existing insulin + cells, suggesting that islet...

... in epithelial character is associated with the appearance of nestin-positive transitional cells. Lineage tracing involving Cre/lox-mediated genetic cell labeling reveals that acinar-to-ductal metaplasia represents a true transdifferentiation event, mediated by initial dedifferentiation of mature exocrine cells...

... at the cellular level. Retina regeneration can occur in two distinct manners. The first is via transdifferentiation, which is induced by members of the Fibroblast growth factor (Fgf) family. The second type of retinal regeneration occurs from the anterior margin of the eye, near the ciliary body (CB) and ciliary...

... induced cell proliferation, alveolar hyperplasia and transdifferentiation of mammary epithelial cells into squamous epithelial cells. Consequently, all mutant mice developed squamous cell carcinoma and/or mammary abscesses between 5 and 16 months of age. We demonstrated that absence of Smad4 resulted in β...

... Transdifferentiation Organ development comprises a cascade of fate decisions, typically starting with a broad regional specification, followed by increasingly elaborate differentiation. The Drosophila imaginal disc provides a useful system in which to address these processes; we focus on the regional...

... 10 2001 © 2002. 2002 β-catenin Lef1 Epidermis Transdifferentiation Hair follicles Tumours Mouse The Wnt signalling pathway controls many morphogenetic events during embryonic development ( Miller and Moon, 1996 ). Secreted Wnt proteins bind to transmembrane receptors...