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Keywords: Transcriptional regulation
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev193417.
Published: 30 November 2020
... Transcriptional regulation Wnt/β-catenin For >30 years it has been recognised that cardiomyocyte proliferation is shut down during early postnatal development of the mammalian heart ( Rumyantsev and Borisov, 1987 ; Soonpaa et al., 1996 ). As proliferative potential is lost, cardiomyocytes undergo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev186023.
Published: 4 June 2020
... is identified involving protein-protein interactions. Dental epithelial stem cells Pitx2 Shh Signaling centers Sox2 Transcriptional regulation Stem cell niche Craniofacial/tooth development Irx1 Enamel knot Pituitary homeobox 2 ( Pitx2 ), is a crucial transcription factor that regulates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
... pop-1 , support the model that POP-1 TCF induces differentiation at a high nuclear level, whereas low nuclear POP-1 promotes seam cell self-renewal. Before symmetric division, the transcriptional regulator RNT-1 Runx and cofactor BRO-1 CBFβ temporarily bypass Wnt/β-catenin asymmetry by downregulating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
... interests The authors declare no competing or financial interests. © 2019. Published by The Company of Biologists Ltd 2019 Summary: In this Review, we discuss emerging concepts of the various levels of epigenetic control of transcriptional regulation in the maintenance and exit from mouse...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177063.
Published: 19 September 2019
... border of the expression domain of Tbx6 protein. During somite segmentation, the expression domain of Tbx6 is regressed by Ripply-meditated degradation of Tbx6 protein. Although the expression of zebrafish tbx6 remains restricted to the PSM, the transcriptional regulation of tbx6 remains poorly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev174094.
Published: 5 July 2019
... time that SWI/SNF and PRC1 cooperate during gametogenesis to regulate transcription. SWI/SNF chromatin remodeling BRG1 Transcriptional regulation SCML2 Spermatogenesis is a developmental cascade in which genetic information is passed on from mitotic precursors to meiotically derived...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (9): dev157081.
Published: 30 April 2018
... of the STM gene regulatory network (GRN) are largely unknown. Here, we show that transcriptional regulators are overrepresented among STM-regulated genes and, using these as GRN components in Bayesian network analysis, we infer STM GRN associations and reveal regulatory relationships between STM and factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4704–4719.
Published: 15 December 2017
... differentiation of the collecting duct system. Kidney Branching morphogenesis Cell polarity Transcriptional regulation Gdnf-Gfrα1-Ret pathway Collecting duct Branching morphogenesis is the process by which simple epithelium arborizes into an elaborate network. The molecular and cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3855–3866.
Published: 1 November 2017
.... Precision Accuracy Drosophila development Embryo Transcriptional regulation Modeling In animals, changes in gene regulation are associated with phenotypic changes within and between species ( Chen and Rajewsky, 2007 ; Gompel et al., 2005 ; McGregor et al., 2007 ; Simpson, 2007 ; Wittkopp...
Journal Articles
Journal: Development
Development (2017) 144 (17): 3168–3176.
Published: 1 September 2017
... Spalt Vein patterning Drosophila wing Transcriptional regulation Pattern formation is a developmental operation that generates bi-dimensional arrays of cells with particular differentiation characteristics ( Martin et al., 2016 ). Classical examples of pattern formation processes that have...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (14): 2606–2617.
Published: 15 July 2017
...-establishment of DNA methylation ( Stewart et al., 2015 ; Dahl et al., 2016 ; Liu et al., 2016 ; Zhang et al., 2016 ). Histone methylation Oogenesis Pre-implantation development Transcriptional regulation Mouse Highlighted article: Oocyte-specific knockout of Setd1b in mouse disrupts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2629–2639.
Published: 15 July 2017
... not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancers were able...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4272–4278.
Published: 15 November 2016
... in transient or stable transgenic animal lines. DamID Transcription factor Transcriptional regulation Chromatin profiling Epigenetics E. coli Dam (eDam) displays specific methylation activity on its cognate GATC but also minor unspecific methylation on near-cognate sequences ( Horton...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2767–2779.
Published: 1 August 2016
... of endogenous retroviruses and enable successful progression through meiosis and mitosis. Histone methylation Meiosis Mitosis Pre-implantation development Transcriptional regulation Mouse female germ cells enter meiosis during fetal development and arrest at the dictyate stage of meiotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3286–3293.
Published: 1 October 2015
... approaches reveal that Nkx2.2, Nkx6.1 and Olig2 directly repress multiple alternative fates during mammalian neural progenitor fate specification. Transcriptional regulation Fate specification Neural development Mouse Sonic hedgehog (Shh) signaling is crucial for the specification of ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2972–2980.
Published: 1 September 2015
... of unsynapsed chromatin (MSUC), which shows similarities to the DNA damage response to replication stress in somatic cells. Meiosis Spermatogenesis Transcriptional regulation CHEK1 Mouse Transcription of protein-coding genes from the male sex chromosomes is repressed during the first meiotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2653–2664.
Published: 1 August 2015
... , and demonstrate that decreased Pdgfrb dosage in conditional Pbx1 mutants substantially rescues vascular patterning defects and neonatal survival. These findings identify, for the first time, an in vivo transcriptional regulator of PDGFRβ, and reveal a previously unappreciated role for VMCs in systems-level...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2549–2553.
Published: 1 August 2015
...@neurosurg.ucsf.edu ) Competing interests The author declares no competing or financial interests. © 2015. Published by The Company of Biologists Ltd 2015 Summary: A recent Keystone Symposium highlighted major advances in our comprehension of the epigenetic and transcriptional regulation of stem...
Journal Articles
Journal: Development
Development (2015) 142 (1): 70–81.
Published: 1 January 2015
... by The Company of Biologists Ltd 2015 Summary : Geminin recruits epigenetic regulators to modulate the expression of hematopoietic multipotency genes and the production of stem/progenitor cells in the fetal hematopoietic system. Geminin Fetal hematopoiesis HoxA9 Transcriptional regulation Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2959–2971.
Published: 1 August 2014
... declare no competing financial interests. 5 9 2013 28 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Wnt signaling R-spondins Cardiac development Transcriptional regulation Angiogenesis Nkx2-5 Rspo3 The spatiotemporal aspects of cardiac development...
Includes: Supplementary data