... the role of signaling and transcription factors, as well as novel modifying factors including chromatin remodelers, small RNAs and post-translational regulators, which control the availability and longevity of major NCC players. * Author for correspondence ( crdrogers@ucdavis.edu ) Competing...

... modifiers – and transcription factors during priming and outgrowth of rice ( Oryza sativa ) crown root primordia. Functional analyses of rice transcription factors from WUSCHEL-RELATED HOMEOBOX and PLETHORA gene families reveal their non-redundant and species-specific roles in determining the root...

... in progenitors. Pax6 Transcription factors Prethalamus Neuronal morphogenesis Axon initial segment Neuronal activity Medical Research Council Mr/J003662/1 Mr/N012291/1 Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 Bb/N006542/1...

...). (A) Schematic of a young gynoecium at stage 7, when two different domains – lateral (green) and medial (yellow) – are visible. (B) At stage 8, the carpel margin meristem (red) becomes specified. (C) The activity of the CMM is maintained by the activity of the bHLH transcription factors SPATULA (SPT) and HECATE...

...-loop-helix (bHLH) transcription factor (TF), contributes to all of these events, but how it coordinates these independently is still unknown. Here, we demonstrate that NeuroD1 expression is accompanied by a gain of active chromatin at a large number of genomic loci. Interestingly, transcriptional...

...Stephanie A. Campbell; Tabea L. Stephan; Jeremy Lotto; Rebecca Cullum; Sibyl Drissler; Pamela A. Hoodless ABSTRACT Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell...

... to malignant tumours after allografting to adult hosts. We combined transcriptomic data from these hyperplasias with chromatin occupancy data for Dpn, a Hes transcription factor, to identify genes regulated by Hes factors in this process. We show that the Notch/Hes axis represses a cohort of transcription...

...Albert Tsai; Rafael Galupa; Justin Crocker ABSTRACT Developmental enhancers drive gene expression in specific cell types during animal development. They integrate signals from many different sources mediated through the binding of transcription factors, producing specific responses in gene...

... and formation of the contractile apparatus that defines functional myofibers. Homeobox genes Muscle stem cells Myogenesis Skeletal muscle Transcription factors Epigenetics Cell signaling Differentiation Summary: Differentiation of adult myoblasts requires the interaction of β-catenin...

...Dimitrios K. Papadopoulos; Kassiani Skouloudaki; Ylva Engström; Lars Terenius; Rudolf Rigler; Christoph Zechner; Vladana Vukojević; Pavel Tomancak; Allon Klein; Barbara Treutlein ABSTRACT The variability in transcription factor concentration among cells is an important developmental determinant...

...-loop-helix family of transcription factors that are co-expressed in the erythroid lineage. Previous studies have suggested that Scl is essential for primitive erythropoiesis. However, analysis of single-cell RNA-seq data of early embryos showed that primitive erythroid cells express both Scl and Lyl1...

... to study the origin of human primordial germ cells, prompting further consideration of the somatic cell fate decisions that occur during early human development. Primordial germ cells Gastrulation Epiblast Human development Epigenetic resetting Transcription factors Signalling Amnion...

..., yet plastic, mature organ. Over the past couple of decades, studies have revealed that hormonal signals, transcription factors and miRNAs play major roles during leaf development, and more recent findings have highlighted the contribution of mechanical signals to leaf growth. In this Review, we...

... of their formation is still limited. To gain insight into the molecular mechanisms of connective tissue specification, we selected five zinc-finger transcription factors – OSR1, OSR2, EGR1, KLF2 and KLF4 – based on their expression patterns and/or known involvement in connective tissue subtype differentiation. RNA...

..., development of the Arabidopsis gynoecium is tightly controlled by distribution and synthesis of the plant hormone auxin. The functions of several transcription factors (TFs) have been linked with auxin dynamics during gynoecium development; yet how their activities are coordinated is not known. Here, we show...

... are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other...

... of binding their genomic targets during mitosis. These so-called ‘mitotic bookmarking factors’ encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development...

...Maria L. Golson; Klaus H. Kaestner Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging from yeast to humans. They regulate diverse biological processes both during development and throughout adult life. Mutations in many Fox genes are associated with human...

...Paulina Anna Latos; Myriam Hemberger Trophoblast stem cells (TSCs) retain the capacity to self-renew indefinitely and harbour the potential to differentiate into all trophoblast subtypes of the placenta. Recent studies have shown how signalling cascades integrate with transcription factor circuits...

...Israt Jahan; Ning Pan; Jennifer Kersigo; Bernd Fritzsch Atoh1 , a basic helix-loop-helix (bHLH) transcription factor (TF), is essential for the differentiation of hair cells (HCs), mechanotransducers that convert sound into auditory signals in the mammalian organ of Corti (OC). Previous work...