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Keywords: Transcription factor
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Journal Articles
Journal: Development
Development (2024) 151 (5): dev202420.
Published: 28 February 2024
... and cleft lip and/or palate. The highly conserved transcription factor grainyhead-like 2 (Grhl2) is a crucial regulator of tissue fusion, with mouse models lacking GRHL2 function presenting with a fully penetrant open cranial neural tube, facial and abdominal clefting (abdominoschisis), and an open...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (2): dev201155.
Published: 18 January 2023
..., and they create opportunities for diverse developmental strategies to emerge between species. To study the contribution of duplicated genes to human early development, we examined the evolution and function of NANOGP1 , a tandem duplicate of the transcription factor NANOG . We found that NANOGP1 and NANOG have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (1): dev192476.
Published: 16 January 2023
...Katharine A. Hubert; Deneen M. Wellik ABSTRACT Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and temporally regulated during development in a manner...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (15): dev200750.
Published: 2 August 2022
.... Here, we demonstrate that a restricted pool of progenitors in the mouse spinal cord, expressing the transcription factor Dbx1, produces a subset of astrocytes, in addition to interneurons. Ventral p0-derived astrocytes (vA0 cells) exclusively populate intermediate regions of spinal cord...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (14): dev200937.
Published: 25 July 2022
... and glutamatergic neurons that have been associated with a variety of functions, including sleep regulation. However, the molecular characteristics and development of MRF neurons are poorly understood. As the transcription factor, Gata2 is required for the development of all GABAergic neurons derived from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (11): dev199508.
Published: 13 June 2022
... of transcription factors with a mutually repressive relationship. The mechanism by which Dlx1/2 repress progenitor and oligodendrocyte fate, while promoting transcription of genes needed for differentiation, is not fully understood. We identified a motif within DLX1 that binds RBBP4, a NuRD complex subunit. ChIP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200260.
Published: 11 April 2022
... in response to various environmental cues, but the transcriptional machinery controlling beige adipocyte development and thermogenesis remains largely unknown. By analyzing beige adipocyte-specific knockout mice, we identified a transcription factor, forkhead box P4 (FOXP4), that differentially governs beige...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199534.
Published: 7 September 2021
... the intervening region, referred to as the maxillomandibular junction (the hinge), maintains separation of the mandibular and maxillary domains. One cap signal is GATA3, a member of the GATA family of zinc-finger transcription factors with a distinct expression pattern in the ventral-most part of the mandibular...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (13): dev199589.
Published: 6 July 2021
... work is properly attributed. Highlighted Article: A transcriptome atlas of Arabidopsis embryos constructed from single nuclei reveals cell-specific epigenetic and transcriptional regulatory features. Arabidopsis Embryo Single-nucleus RNA-seq Gene expression Transcription factor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199538.
Published: 7 June 2021
...Izumi Oda-Ishii; Deli Yu; Yutaka Satou ABSTRACT Zic-r.a, a maternal transcription factor, specifies posterior fate in ascidian embryos. However, its direct target, Tbx6-r.b , does not contain typical Zic-r.a-binding sites in its regulatory region. Using an in vitro selection assay, we found...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (16): dev190181.
Published: 25 August 2020
... transcription factors in invertebrates, but only a few examples of such regulators have been provided in vertebrates. We hypothesised that TCF7L2 regulates different stages of postmitotic differentiation in the thalamus, and functions as a thalamic terminal selector. To investigate this hypothesis, we used...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184432.
Published: 5 February 2020
... photoreceptor CREs from wild-type and mutant mouse retinas, defined by presence or absence, respectively, of the rod-specific transcription factor (TF) Nrl . Nrl -dependent ncRNA expression strongly correlated with epigenetic profiles of rod and cone photoreceptors, identified thousands of candidate rod...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (23): dev176701.
Published: 2 December 2019
... lifespan in mammals. An oocyte-specific transcription factor cascade controls oocyte development, and some of these transcription factors, such as newborn ovary homeobox gene ( NOBOX ), are candidate genes for primary ovarian insufficiency in women. Transcription factors are frequently modified by the post...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (19): dev178780.
Published: 30 September 2019
..., plays critical roles in terminal differentiation. During skeletal myogenesis, BAF60C independently forms a preassembled complex with the muscle-specific transcription factor MyoD. Subsequently, p38α/β phosphorylates BAF60C at threonine 229, which then promotes BAF recruitment to the regulatory regions...
Journal Articles