... mutant that shows strong defects in the neuromuscular connectivity pattern. In piranha mutant embryos, permanent defasciculation errors occur at specific choice points in all motor pathways. Positional cloning of piranha revealed point mutations in tolloid-related 1 ( tlr1 ), an evolutionarily conserved...

...Mihaela Serpe; Amy Ralston; Seth S. Blair; Michael B. O'Connor The Drosophila tolloid ( tld ) and tolloid related ( tlr ) gene products belong to a family of developmentally important proteases that includes Bone Morphogenetic Protein 1 (Bmp1). Tld is required early in Drosophila development...

...Lise Zakin; E. M. De Robertis Twisted gastrulation (Tsg) is a secreted protein that regulates Bmp signaling in the extracellular space through its direct interaction with Bmp/Dpp and Chordin (Chd)/Short gastrulation (Sog). The ternary complex of Tsg/Chd/Bmp is cleaved by the metalloprotease Tolloid...

... BMP4 Tolloid BMP signaling Xenopus CCN family Secreted signaling molecules are critical for coordinating cell fate specification and cell behavior. Bone morphogenetic proteins (BMPs) comprise the largest subgroup of the transforming growth factor beta (TGFβ)superfamily of secreted...

...Michael Oelgeschläger; Bruno Reversade; Juan Larraín; Shawn Little; Mary C. Mullins; E. M. De Robertis The determination of the vertebrate dorsoventral body axis is regulated in the extracellular space by a system of interacting secreted molecules consisting of BMP, Chordin, Tolloid and Twisted...

... ( Oelgeschläger et al., 2000 ; Ross et al., 2001 ; Chang et al., 2001 ). In Drosophila , Tsg changes the specificity of Tolloid cleavage causing the formation of a new fragment of the Chordin homolog Sog, called Supersog, which has been found both in embryo extracts and by in vitro digestion of Sog...

... inhibitors of Bmps, such as Chordin, Noggin and Follistatin, are implicated in dorsal mesodermal and neural development. We investigated the role of Tolloid, a metalloprotease that can cleave Chordin and increase Bmp activity, in patterning the dorsoventral axis of the zebrafish embryo. Injection of tolloid...

..., appears to play the central role in dorsal ectoderm formation, as mutations in this gene confer the most severe mutant phenotype of this group of genes. dpp’s activity is modulated by tolloid , which also has a role in the determination of dorsal cell fate. tolloid encodes a protein that contains...

... and dorsolateral regions of the embryo adopt fates characteristic of more ventrally derived cells ( Irish and Gelbart (1987) Genes Dev . 1, 868-879). Here we describe the phenotypes caused by alleles of another of this set of genes, tolloid , and show that tolloid is required for dorsal, but not dorsolateral...