...Anisha Solanki; Diana C. Yánez; Ching-In Lau; Jasmine Rowell; Alessandro Barbarulo; Susan Ross; Hemant Sahni; Tessa Crompton ABSTRACT Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate from CD4 − CD8 − double-negative (DN) cell to CD4 + CD8 + double...

... conditional deletion of Gli3 from thymocytes did not. Conditional deletion of Shh from TECs increased differentiation to SP4, and expression of Shh was upregulated in the Gli3-deficient thymus. Use of a transgenic Hh reporter showed that the Hh pathway was active in thymocytes, and increased in the Gli3...