... effects of these factors have posed a challenge for understanding the determinants of mitotic or transgenerational inheritance of the epigenetic perturbation. To tackle this problem, we manipulated the epigenetic states of various target genes using a tetracycline-dependent transcription factor...

...Bruno Bello; Diana Resendez-Perez; Walter J. Gehring ABSTRACT In order to evaluate the efficiency of the tetracycline-regulated gene expression system in Drosophila , we have generated transgenic lines expressing a tetracycline-controlled transactivator protein ( tTA ), with specific expression...