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Keywords: Testis
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
... of proteins mediates movement of specific cargo proteins when bound to karyopherin β. Karyopherin α genes have distinct expression patterns in mouse testis, implying they may have unique roles during mammalian spermatogenesis. Here, we use a loss-of-function approach to determine specifically the role...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (18): dev194886.
Published: 25 September 2020
... by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Zebrafish Nedd8 plays an important role in controlling ovarian maturation through suppressing androgen receptor activity. Nedd8 Zebrafish Androgen receptor Ovary Testis Neddylation Total RNA...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev185884.
Published: 13 July 2020
...Aya Uchida; Sadman Sakib; Elodie Labit; Sepideh Abbasi; R. Wilder Scott; T. Michael Underhill; Jeff Biernaskie; Ina Dobrinski ABSTRACT In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of sperm and luminal fluid, while secreting growth factors and extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183251.
Published: 03 February 2020
.... , Wegner , M. and Scherer , G. ( 2009 ). Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8 . Dev. Biol.   327 , 301 - 312 . 10.1016/j.ydbio.2008.12.011 Becht , E. , McInnes , L. , Healy , J...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (13): dev174292.
Published: 28 June 2019
...John E. La Marca; Sarah T. Diepstraten; Amy L. Hodge; Hongyan Wang; Adam H. Hart; Helena E. Richardson; W. Gregory Somers ABSTRACT One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the Drosophila melanogaster testis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173088.
Published: 13 May 2019
...Ellen K. Velte; Bryan A. Niedenberger; Nicholas D. Serra; Anukriti Singh; Lorena Roa-DeLaCruz; Brian P. Hermann; Christopher B. Geyer; Allon Klein; Barbara Treutlein ABSTRACT In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... no competing or financial interests. 10 9 2018 3 12 2018 © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Primer reviews the role of JAK/STAT signaling in stem cells and regeneration in Drosophila testis, intestine and appendages, and discusses...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169136.
Published: 05 December 2018
... relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid cell and vascular pericyte populations in the neonatal testis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (15): dev161323.
Published: 13 August 2018
..., and spermatids connected by intercellular bridges in the mammalian testis . Biol. Reprod.   4 , 195 - 215 . 10.1093/biolreprod/4.2.195 Fayomi , A. P. and Orwig , K. E. ( 2018 ). Spermatogonial stem cells and spermatogenesis in mice, monkeys and men . Stem Cell Res.   29 , 207 - 214...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (13): dev160465.
Published: 09 July 2018
.... Additionally, blocking RA signaling in Leydig cells resulted in increased permeability of the blood-testis barrier, decreased levels of the steroidogenic enzyme cytochrome P450 17a1 and decreased testosterone levels. Surprisingly, the epididymides of the mutant mice also displayed an abnormal phenotype...
Journal Articles
Journal: Development
Development (2016) 143 (21): 3914–3925.
Published: 01 November 2016
... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
...Chang Liu; Karina Rodriguez; Humphrey H.-C. Yao Testis morphogenesis is a highly orchestrated process involving lineage determination of male germ cells and somatic cell types. Although the origin and differentiation of germ cells are known, the developmental course specific for each somatic cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
... synthesis and degradation. A group of genes that are required for mRNA splicing and protein translation contributes to both GSC self-renewal and early germ cell differentiation. Loss of genes in the protein degradation pathway in cyst cells leads to testis tumors consisting of overproliferated germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1655–1662.
Published: 15 May 2016
... development and disease progression. However, its function in adult stem cell maintenance is largely unknown. Here, we report the function of SUMOylation in somatic cyst stem cell (CySC) self-renewal in adult Drosophila testis. The SUMO pathway cell-autonomously regulates CySC maintenance. Reduction...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1633–1637.
Published: 15 May 2016
... all the difference was a surprise to many. Scientifically, the discovery of SRY/Sry helped to open the field of sex determination. It provided an entry point into the genetics and embryology underlying testis development, explained cases of sex reversal, and provided an important new diagnostic...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1502–1511.
Published: 01 May 2016
... , Y. ( 1972 ). Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal . Physiol. Rev.   52 , 198 - 236 . Cooke , P. S. ( 1991 ). Thyroid hormones and testis development: a model system for increasing testis growth and sperm production . Ann...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 01 March 2016
...Qing Ma; Margaret de Cuevas; Erika L. Matunis Sexual identity is continuously maintained in specific differentiated cell types long after sex determination occurs during development. In the adult Drosophila testis, the putative transcription factor Chronologically inappropriate morphogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2598–2609.
Published: 01 August 2015
...Christopher M. Smendziuk; Anat Messenberg; A. Wayne Vogl; Guy Tanentzapf Soma-germline interactions play conserved essential roles in regulating cell proliferation, differentiation, patterning and homeostasis in the gonad. In the Drosophila testis, secreted signalling molecules of the JAK-STAT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (2): 352–362.
Published: 15 January 2015
...-mediated mRNA decay Premature termination codon Alternative splicing Sertoli cell 3′UTR shortening Testis Gonocyte Spermatogenesis Sterility RNA-Seq Mouse Sertoli cells (SCs) are required not only for male-specific sexual differentiation during embryonic development, but also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3662–3671.
Published: 01 October 2014
... financial interests. 5 6 2014 1 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 DMRT6 DMRT1 Spermatogenesis Meiosis Testis Mouse Male mammals continuously produce large numbers of sperm from puberty onwards, in some cases for decades. This sustained...
Includes: Supplementary data