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Keywords: Testis
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Journal Articles
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (6): dev200706.
Published: 20 March 2023
... and Tcf21-CreER + stromal cells in the testis, but Sertoli cells are the only physiologically important source of SCF that contributes to spermatogenesis. Spermatogenesis Stem cell factor Sertoli cell Testis Mammalian spermatogenesis is a complex developmental process based on a robust...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (5): dev201060.
Published: 13 March 2023
... . 10.3109/08977199509036882 Hiramatsu , R. , Kanai , Y. , Mizukami , T. , Ishii , M. , Matoba , S. , Kanai-Azuma , M. , Kurohmaru , M. , Kawakami , H. and Hayashi , Y. ( 2003 ). Regionally distinct potencies of mouse XY genital ridge to initiate testis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (22): dev200713.
Published: 16 November 2022
... initiation in vitro and isolate pure populations of millions of cells undergoing the mitosis-to-meiosis transition for biochemical assays. Testis Spermatogenesis Meiosis Spermatogonia Spermatocytes National Institutes of Health http://dx.doi.org/10.13039/100000002 HD090083 HD090007...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (13): dev200205.
Published: 1 July 2022
... were then added to cell lysate overnight at 4°C. Before performing the western blot, beads were washed five times with PBS. The expressions of Sohlh1 and Sohlh2 were detected by in situ hybridization with digoxigenin (DIG)-labeled probes on frozen testis sections. The slides were fixed...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
... of proteins mediates movement of specific cargo proteins when bound to karyopherin β. Karyopherin α genes have distinct expression patterns in mouse testis, implying they may have unique roles during mammalian spermatogenesis. Here, we use a loss-of-function approach to determine specifically the role...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev185884.
Published: 13 July 2020
...Aya Uchida; Sadman Sakib; Elodie Labit; Sepideh Abbasi; R. Wilder Scott; T. Michael Underhill; Jeff Biernaskie; Ina Dobrinski ABSTRACT In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of sperm and luminal fluid, while secreting growth factors and extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183251.
Published: 3 February 2020
.... , Wegner , M. and Scherer , G. ( 2009 ). Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8 . Dev. Biol.   327 , 301 - 312 . 10.1016/j.ydbio.2008.12.011 Becht , E. , McInnes , L. , Healy , J...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (13): dev174292.
Published: 28 June 2019
...John E. La Marca; Sarah T. Diepstraten; Amy L. Hodge; Hongyan Wang; Adam H. Hart; Helena E. Richardson; W. Gregory Somers ABSTRACT One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the Drosophila melanogaster testis...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... 2018 © 2019. Published by The Company of Biologists Ltd 2019 Summary: This Primer reviews the role of JAK/STAT signaling in stem cells and regeneration in Drosophila testis, intestine and appendages, and discusses the similarities between Drosophila and vertebrates. Drosophila...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169136.
Published: 5 December 2018
... relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid cell and vascular pericyte populations in the neonatal testis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (15): dev161323.
Published: 13 August 2018
.../ Summary: Dynamic cytoplasmic projections connect mammalian spermatogonia and provide patent connections for the sharing of macromolecules during testis development. TEX14 Intercellular bridge Spermatogenesis Spermatogonia Testis Mouse Baboon The foundation of mammalian spermatogenesis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (13): dev160465.
Published: 9 July 2018
.... Additionally, blocking RA signaling in Leydig cells resulted in increased permeability of the blood-testis barrier, decreased levels of the steroidogenic enzyme cytochrome P450 17a1 and decreased testosterone levels. Surprisingly, the epididymides of the mutant mice also displayed an abnormal phenotype...
Journal Articles
Journal: Development
Development (2016) 143 (21): 3914–3925.
Published: 1 November 2016
... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
...Chang Liu; Karina Rodriguez; Humphrey H.-C. Yao Testis morphogenesis is a highly orchestrated process involving lineage determination of male germ cells and somatic cell types. Although the origin and differentiation of germ cells are known, the developmental course specific for each somatic cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
... synthesis and degradation. A group of genes that are required for mRNA splicing and protein translation contributes to both GSC self-renewal and early germ cell differentiation. Loss of genes in the protein degradation pathway in cyst cells leads to testis tumors consisting of overproliferated germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1633–1637.
Published: 15 May 2016
... by The Company of Biologists Ltd 2016 Summary: This Spotlight revisits a landmark paper in developmental biology, published 25 years ago, that reported the sex reversal of an XX mouse carrying an Sry transgene. Sry Sex determination Transgenic mouse Testis One of the most fundamental...