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Keywords: Testis
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (22): dev200713.
Published: 16 November 2022
... Male Contraceptive Initiative S10-OD021615 National Institutes of Health http://dx.doi.org/10.13039/100000002 HD090083 HD090007 HD105963 Testis Spermatogenesis Meiosis Spermatogonia Spermatocytes Summary: Here, we report robust and reliable tools to model mammalian...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (13): dev200205.
Published: 1 July 2022
... Sox3 Testis National Key Research and Development Program of China 2018YFC1003504 Priority Academic Program Development of Jiangsu Higher Education Institutions Yangzhou University http://dx.doi.org/10.13039/501100007062 XKYCX18_111 In mammalian...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
... of proteins mediates movement of specific cargo proteins when bound to karyopherin β. Karyopherin α genes have distinct expression patterns in mouse testis, implying they may have unique roles during mammalian spermatogenesis. Here, we use a loss-of-function approach to determine specifically the role...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (18): dev194886.
Published: 25 September 2020
... by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Zebrafish Nedd8 plays an important role in controlling ovarian maturation through suppressing androgen receptor activity. Nedd8 Zebrafish Androgen receptor Ovary Testis Neddylation Total RNA...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev185884.
Published: 13 July 2020
...Aya Uchida; Sadman Sakib; Elodie Labit; Sepideh Abbasi; R. Wilder Scott; T. Michael Underhill; Jeff Biernaskie; Ina Dobrinski ABSTRACT In mammalian testis, contractile peritubular myoid cells (PMCs) regulate the transport of sperm and luminal fluid, while secreting growth factors and extracellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183251.
Published: 3 February 2020
...). Genes involving ‘integrin-mediated signaling’ and ‘vessel development’ are enriched in SSC-s1 ( Fig. S4B,C ), suggesting these processes may play roles in SSC development. Fig. 3. Undifferentiated SG clusters during the SSC establishment period. (A) UMAP plot of SG from P7 mouse testis. Number...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (13): dev174292.
Published: 28 June 2019
...John E. La Marca; Sarah T. Diepstraten; Amy L. Hodge; Hongyan Wang; Adam H. Hart; Helena E. Richardson; W. Gregory Somers ABSTRACT One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the Drosophila melanogaster testis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173088.
Published: 13 May 2019
...Ellen K. Velte; Bryan A. Niedenberger; Nicholas D. Serra; Anukriti Singh; Lorena Roa-DeLaCruz; Brian P. Hermann; Christopher B. Geyer; Allon Klein; Barbara Treutlein ABSTRACT In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. upd continues to be produced by niche cells in the adult testis but declines with age ( Kiger et al., 2001 ; Toledano et al., 2012 ; Tulina and Matunis, 2001...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169136.
Published: 5 December 2018
... relationship between FLCs and ALCs has not been clarified yet. Here, we reveal that a subset of FLCs dedifferentiate at fetal stages to give rise to ALCs at the pubertal stage. Moreover, the dedifferentiated cells contribute to the peritubular myoid cell and vascular pericyte populations in the neonatal testis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (15): dev161323.
Published: 13 August 2018
.../ Summary: Dynamic cytoplasmic projections connect mammalian spermatogonia and provide patent connections for the sharing of macromolecules during testis development. TEX14 Intercellular bridge Spermatogenesis Spermatogonia Testis Mouse Baboon The foundation of mammalian spermatogenesis...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (13): dev160465.
Published: 9 July 2018
.... Additionally, blocking RA signaling in Leydig cells resulted in increased permeability of the blood-testis barrier, decreased levels of the steroidogenic enzyme cytochrome P450 17a1 and decreased testosterone levels. Surprisingly, the epididymides of the mutant mice also displayed an abnormal phenotype...
Journal Articles
Journal: Development
Development (2016) 143 (21): 3914–3925.
Published: 1 November 2016
... cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
...Chang Liu; Karina Rodriguez; Humphrey H.-C. Yao Testis morphogenesis is a highly orchestrated process involving lineage determination of male germ cells and somatic cell types. Although the origin and differentiation of germ cells are known, the developmental course specific for each somatic cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2930–2945.
Published: 15 August 2016
... synthesis and degradation. A group of genes that are required for mRNA splicing and protein translation contributes to both GSC self-renewal and early germ cell differentiation. Loss of genes in the protein degradation pathway in cyst cells leads to testis tumors consisting of overproliferated germ cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1633–1637.
Published: 15 May 2016
... , B. L. , Goodfellow , P. N. and Fellous , M. ( 1990 ). Genetic evidence equating SRY and the testis-determining factor . Nature   348 , 448 - 450 . 10.1038/348448A0 Beverdam , A. , Wilhelm , D. and Koopman , P. ( 2003 ). Molecular characterization of three gonad...
Journal Articles
Journal: Development
Development (2016) 143 (10): 1655–1662.
Published: 15 May 2016
... development and disease progression. However, its function in adult stem cell maintenance is largely unknown. Here, we report the function of SUMOylation in somatic cyst stem cell (CySC) self-renewal in adult Drosophila testis. The SUMO pathway cell-autonomously regulates CySC maintenance. Reduction...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1502–1511.
Published: 1 May 2016
... histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice. Spermatogonial differentiation Spermatogenesis Retinoic acid Dominant-negative retinoic acid receptor Testis Replication-dependent core histone genes Spermatogenesis is a highly organized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 754–763.
Published: 1 March 2016
...Qing Ma; Margaret de Cuevas; Erika L. Matunis Sexual identity is continuously maintained in specific differentiated cell types long after sex determination occurs during development. In the adult Drosophila testis, the putative transcription factor Chronologically inappropriate morphogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2598–2609.
Published: 1 August 2015
...Christopher M. Smendziuk; Anat Messenberg; A. Wayne Vogl; Guy Tanentzapf Soma-germline interactions play conserved essential roles in regulating cell proliferation, differentiation, patterning and homeostasis in the gonad. In the Drosophila testis, secreted signalling molecules of the JAK-STAT...
Includes: Supplementary data