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Keywords: Teratogenesis
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Journal Articles
Journal: Development
Development (2003) 130 (7): 1449–1459.
Published: 1 April 2003
... Retinoids Retinoic acid Teratogenesis Spina bifida Caudal regression Cyp26a1 RARγ Wnt3a Brachyury Fgf8 Hnf3b Cdx4 Hoxd11 Tbx6 Raldh2 Retinoic acid (RA), a biologically active metabolite of vitamin A(retinol), is a signaling molecule required for normal embryogenesis...
Journal Articles
Journal: Development
Development (1998) 125 (18): 3553–3562.
Published: 15 September 1998
... cholesterol. However, exogenous cholesterol does not restore Shh signaling in cyclopamine-treated explants. These findings suggest that cyclopamine-induced teratogenesis is due to a more direct antagonism of Shh signal transduction. * Author for correspondence (e-mail: roelink@u.washington.edu) © 1998...
Journal Articles
Journal: Development
Development (1995) 121 (12): 3997–4003.
Published: 1 December 1995
...-type embryos fail to elicit malformations in RXR α homozygotes, implicating RXRα as a component in the teratogenic process in the limbs. Heterozygous embryos are intermediate in sensitivity to RA, suggesting the importance of RXRα gene dosage in limb teratogenesis. Expression of the RA-inducible gene...
Journal Articles
Journal Articles
Journal: Development
Development (1987) 99 (2): 247–253.
Published: 1 February 1987
... ethanol yolk-sac function teratogenesis pinocytosis proteolysis rat embryo Excessive ingestion of ethanol, by either pregnant women or by pregnant experimental animals, is known to induce a characteristic pattern of developmental defects known as the fetal alcohol syndrome ( Abel, 1982...
Journal Articles
Journal: Development
Development (1987) 99 (2): 231–238.
Published: 1 February 1987
... Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA 06 10 1986 © 1987 by Company of Biologists 1987 zinc deficiency eye development teratogenesis rat embryo The teratogenicity of zinc deficiency was first demonstrated by Turk and coworkers...
Journal Articles