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Keywords: Tendon
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev186916.
Published: 16 April 2021
...Lauren Bobzin; Ryan R. Roberts; Hung-Jhen Chen; J. Gage Crump; Amy E. Merrill ABSTRACT Tendons and ligaments are fibrous connective tissues vital to the transmission of force and stabilization of the musculoskeletal system. Arising in precise regions of the embryo, tendons and ligaments share many...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev185389.
Published: 24 June 2020
...Jessica W. Chen; Xubo Niu; Matthew J. King; Marie-Therese Noedl; Clifford J. Tabin; Jenna L. Galloway ABSTRACT Tendons and ligaments are crucial components of the musculoskeletal system, yet the pathways specifying these fates remain poorly defined. Through a screen of known bioactive chemicals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180075.
Published: 12 November 2019
... utilised multiple genetic approaches to investigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue development. Mice lacking a Shh cis -enhancer, MFCS4 ( ShhMFCS4/− ), with reduced SHH in dorsal tongue epithelium have perturbed lingual septum tendon formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev170241.
Published: 2 August 2019
...Ryan R. Roberts; Lauren Bobzin; Camilla S. Teng; Deepanwita Pal; Creighton T. Tuzon; Ronen Schweitzer; Amy E. Merrill ABSTRACT Tendon and bone are attached by a transitional connective tissue that is morphologically graded from tendinous to osseous and develops from bipotent progenitors that co...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1159–1164.
Published: 1 April 2017
...Andrea G. Schwartz; Leesa M. Galatz; Stavros Thomopoulos The tendon enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiate and produce mineralized fibrocartilage. The current study investigated the regenerative capacity of this cell population...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3839–3851.
Published: 15 October 2016
...Emmanuelle Havis; Marie-Ange Bonnin; Joana Esteves de Lima; Benjamin Charvet; Cécile Milet; Delphine Duprez The molecular programme underlying tendon development has not been fully identified. Interactions with components of the musculoskeletal system are important for limb tendon formation. Limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4191–4204.
Published: 15 December 2015
...Arul Subramanian; Thomas F. Schilling Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via the ECM to establish connectivity and strengthen attachments under...
Journal Articles
Journal: Development
Development (2015) 142 (14): 2431–2441.
Published: 15 July 2015
...Alice H. Huang; Timothy J. Riordan; Brian Pryce; Jennifer L. Weibel; Spencer S. Watson; Fanxin Long; Veronique Lefebvre; Brian D. Harfe; H. Scott Stadler; Haruhiko Akiyama; Sara F. Tufa; Douglas R. Keene; Ronen Schweitzer The long tendons of the limb extend from muscles that reside in the zeugopod...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1431–1436.
Published: 15 April 2015
...Elly Ordan; Marko Brankatschk; Barry Dickson; Frank Schnorrer; Talila Volk During organogenesis, secreted signaling proteins direct cell migration towards their target tissue. In Drosophila embryos, developing muscles are guided by signals produced by tendons to promote the proper attachment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 1 October 2014
...Emmanuelle Havis; Marie-Ange Bonnin; Isabel Olivera-Martinez; Nicolas Nazaret; Mathilde Ruggiu; Jennifer Weibel; Charles Durand; Marie-Justine Guerquin; Christelle Bonod-Bidaud; Florence Ruggiero; Ronen Schweitzer; Delphine Duprez The molecular signals driving tendon development are not fully...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (10): 2035–2045.
Published: 15 May 2014
...Jessica W. Chen; Jenna L. Galloway Despite the importance of tendons and ligaments for transmitting movement and providing stability to the musculoskeletal system, their development is considerably less well understood than that of the tissues they serve to connect. Zebrafish have been widely used...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2855–2859.
Published: 15 July 2011
...Gabrielle Kardon In March 2011, researchers met for the second Batsheva Seminar on Integrative Perspectives on the Development of the Musculoskeletal System. This meeting was a unique opportunity for researchers working on muscle, connective tissue, tendons, ligaments and bone to discuss...
Journal Articles
Journal: Development
Development (2010) 137 (5): 785–794.
Published: 1 March 2010
...Eliezer Gilsohn; Talila Volk The correct assembly of the myotendinous junction (MTJ) is crucial for proper muscle function. In Drosophila , this junction comprises hemi-adherens junctions that are formed upon arrival of muscles at their corresponding tendon cells. The MTJ mainly comprises muscle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3607–3615.
Published: 1 November 2009
...Bess Wayburn; Talila Volk Correct muscle migration towards tendon cells, and the adhesion of these two cell types, form the basis for contractile tissue assembly in the Drosophila embryo. While molecules promoting the attraction of muscles towards tendon cells have been described, signals involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 791–801.
Published: 1 March 2009
...-helix transcription factor, as a new marker of stomach mesenchyme and find that expression of Scleraxis defines the presence of two tendons closely associated to the two visceral smooth muscles. Using targeted gene misexpression, we show that FGF signaling is sufficient to induce Scleraxis expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (14): 2697–2708.
Published: 15 July 2007
...Nicholas D. Murchison; Brian A. Price; David A. Conner; Douglas R. Keene; Eric N. Olson; Clifford J. Tabin; Ronen Schweitzer The scleraxis ( Scx ) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1269–1278.
Published: 1 April 2007
...Arul Subramanian; Bess Wayburn; Thomas Bunch; Talila Volk Organogenesis of the somatic musculature in Drosophila is directed by the precise adhesion between migrating myotubes and their corresponding ectodermally derived tendon cells. Whereas the PS integrins mediate the adhesion between these two...
Journal Articles
Journal: Development
Development (2005) 132 (6): 1305–1314.
Published: 15 March 2005
... specification and differentiation. * Author for correspondence (e-mail: a.munsterberg@uea.ac.uk ) 14 1 2005 ©2005. 2005 FGF signalling Chick Somite Tendon Rib Mkp3 ERK MAP kinase Scleraxis During vertebrate embryogenesis, epithelial somites are generated sequentially...
Journal Articles
Journal: Development
Development (2005) 132 (3): 515–528.
Published: 1 February 2005
...Ava E. Brent; Thomas Braun; Clifford J. Tabin Proper formation of the musculoskeletal system requires the coordinated development of the muscle, cartilage and tendon lineages arising from the somitic mesoderm. During early somite development, muscle and cartilage emerge from two distinct...
Journal Articles
Journal: Development
Development (2004) 131 (16): 3885–3896.
Published: 15 August 2004
...Ava E. Brent; Clifford J. Tabin During somite development, a fibroblast growth factor (FGF) signal secreted from the myotome induces formation of a scleraxis ( Scx )-expressing tendon progenitor population in the sclerotome, at the juncture between the future lineages of muscle and cartilage. While...