...Arul Subramanian; Lauren F. Kanzaki; Thomas F. Schilling ABSTRACT Entheses transmit force from tendons and ligaments to the skeleton. Regional organization of enthesis extracellular matrix (ECM) generates differences in stiffness required for force transmission. Two key transcription factors co...

...Yudai Ono; Saundra Schlesinger; Kanako Fukunaga; Shinsei Yambe; Tempei Sato; Takako Sasaki; Chisa Shukunami; Hiroshi Asahara; Masafumi Inui ABSTRACT Movement of the vertebrate body is supported by the connection of muscle, tendon and bone. Each skeletal muscle in the vertebrate body has a unique...

...Lauren Bobzin; Ryan R. Roberts; Hung-Jhen Chen; J. Gage Crump; Amy E. Merrill ABSTRACT Tendons and ligaments are fibrous connective tissues vital to the transmission of force and stabilization of the musculoskeletal system. Arising in precise regions of the embryo, tendons and ligaments share many...

...Jessica W. Chen; Xubo Niu; Matthew J. King; Marie-Therese Noedl; Clifford J. Tabin; Jenna L. Galloway ABSTRACT Tendons and ligaments are crucial components of the musculoskeletal system, yet the pathways specifying these fates remain poorly defined. Through a screen of known bioactive chemicals...

... utilised multiple genetic approaches to investigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue development. Mice lacking a Shh cis -enhancer, MFCS4 ( ShhMFCS4/− ), with reduced SHH in dorsal tongue epithelium have perturbed lingual septum tendon formation...

...Ryan R. Roberts; Lauren Bobzin; Camilla S. Teng; Deepanwita Pal; Creighton T. Tuzon; Ronen Schweitzer; Amy E. Merrill ABSTRACT Tendon and bone are attached by a transitional connective tissue that is morphologically graded from tendinous to osseous and develops from bipotent progenitors that co...

...Andrea G. Schwartz; Leesa M. Galatz; Stavros Thomopoulos The tendon enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiate and produce mineralized fibrocartilage. The current study investigated the regenerative capacity of this cell population...

...Emmanuelle Havis; Marie-Ange Bonnin; Joana Esteves de Lima; Benjamin Charvet; Cécile Milet; Delphine Duprez The molecular programme underlying tendon development has not been fully identified. Interactions with components of the musculoskeletal system are important for limb tendon formation. Limb...

...Arul Subramanian; Thomas F. Schilling Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via the ECM to establish connectivity and strengthen attachments under...

...Alice H. Huang; Timothy J. Riordan; Brian Pryce; Jennifer L. Weibel; Spencer S. Watson; Fanxin Long; Veronique Lefebvre; Brian D. Harfe; H. Scott Stadler; Haruhiko Akiyama; Sara F. Tufa; Douglas R. Keene; Ronen Schweitzer The long tendons of the limb extend from muscles that reside in the zeugopod...

...Elly Ordan; Marko Brankatschk; Barry Dickson; Frank Schnorrer; Talila Volk During organogenesis, secreted signaling proteins direct cell migration towards their target tissue. In Drosophila embryos, developing muscles are guided by signals produced by tendons to promote the proper attachment...

...Emmanuelle Havis; Marie-Ange Bonnin; Isabel Olivera-Martinez; Nicolas Nazaret; Mathilde Ruggiu; Jennifer Weibel; Charles Durand; Marie-Justine Guerquin; Christelle Bonod-Bidaud; Florence Ruggiero; Ronen Schweitzer; Delphine Duprez The molecular signals driving tendon development are not fully...

...Jessica W. Chen; Jenna L. Galloway Despite the importance of tendons and ligaments for transmitting movement and providing stability to the musculoskeletal system, their development is considerably less well understood than that of the tissues they serve to connect. Zebrafish have been widely used...

...Gabrielle Kardon In March 2011, researchers met for the second Batsheva Seminar on Integrative Perspectives on the Development of the Musculoskeletal System. This meeting was a unique opportunity for researchers working on muscle, connective tissue, tendons, ligaments and bone to discuss...

...Eliezer Gilsohn; Talila Volk The correct assembly of the myotendinous junction (MTJ) is crucial for proper muscle function. In Drosophila , this junction comprises hemi-adherens junctions that are formed upon arrival of muscles at their corresponding tendon cells. The MTJ mainly comprises muscle...

...Bess Wayburn; Talila Volk Correct muscle migration towards tendon cells, and the adhesion of these two cell types, form the basis for contractile tissue assembly in the Drosophila embryo. While molecules promoting the attraction of muscles towards tendon cells have been described, signals involved...

...-helix transcription factor, as a new marker of stomach mesenchyme and find that expression of Scleraxis defines the presence of two tendons closely associated to the two visceral smooth muscles. Using targeted gene misexpression, we show that FGF signaling is sufficient to induce Scleraxis expression...

...Nicholas D. Murchison; Brian A. Price; David A. Conner; Douglas R. Keene; Eric N. Olson; Clifford J. Tabin; Ronen Schweitzer The scleraxis ( Scx ) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function, we produced...

...Arul Subramanian; Bess Wayburn; Thomas Bunch; Talila Volk Organogenesis of the somatic musculature in Drosophila is directed by the precise adhesion between migrating myotubes and their corresponding ectodermally derived tendon cells. Whereas the PS integrins mediate the adhesion between these two...

.... Asterisks indicate missing ribs (B,C,E,H) compared with rib present in control (G). dm,dermomyotome; my, myotome; sc, sclerotome. * Author for correspondence (e-mail: a.munsterberg@uea.ac.uk ) 14 1 2005 ©2005. 2005 FGF signalling Chick Somite Tendon Rib Mkp3 ERK MAP...