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Keywords: Telomere length
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Journal Articles

The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length

Claire Bénard, Brent McCright, Yue Zhang, Stephanie Felkai, Bernard Lakowski, Siegfried Hekimi
Journal: Development
Development (2001) 128 (20): 4045–4055.
https://doi.org/10.1242/dev.128.20.4045
Published: 15 October 2001
... maturation and the two- to four-cell embryonic stage. Positional cloning of clk-2 reveals that it encodes a protein homologous to S. cerevisiae Tel2p. In yeast, the gene TEL2 regulates telomere length and participates in gene silencing at subtelomeric regions. In C. elegans , clk-2 mutants have elongated...
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