... of the molecular mechanisms of regeneration. Heart Regeneration Spinal cord Tail Xenopus Appendage The goal of regenerative medicine is to identify novel therapies aimed at stimulating a full regenerative response in humans following injury, disease or during ageing. As such, uncovering...

...-terminal tail are not clear. To address this, we studied the effects of tail mutations on mitochondria transport, determinant mRNA localization and cytoplasmic streaming in Drosophila . Our results show that two biochemically defined elements of the tail – the ATP-independent microtubule-binding sequence...

... and mouse embryos. The analyses showed a continued cell movement resembling gastrulation associated with EMT during the early tailbud stage of both embryos. Such gastrulation-like cell movement was gradually attenuated by the absence of EMT during tail development. The kinetics of the expression pattern...

... transport during Xenopus tail regeneration. We show that activity of the V-ATPase H + pump is required for regeneration but not wound healing or tail development. The V-ATPase is specifically upregulated in existing wound cells by 6 hours post-amputation. Pharmacological or molecular genetic loss of V...

...Ujwal J. Pyati; Ashley E. Webb; David Kimelman Bone morphogenetic protein (Bmp) signaling is crucial for the formation and patterning of zebrafish ventral and posterior mesoderm. Mutants defective in the Bmp pathway have expanded trunk muscle, abnormal tails and severely impaired development...

...Cesare Gargioli; Jonathan M. W. Slack The tail of the Xenopus tadpole will regenerate following amputation, and all three of the main axial structures – the spinal cord, the notochord and the segmented myotomes – are found in the regenerated tail. We have investigated the cellular origin of each...

... proteins. We suggest a fundamental role for epithelial specific expression of Hoxa13 in the epithelial-mesenchymal interaction necessary for tail growth and posterior GGU patterning. *Author for correspondence (e-mail: robertsd@helix.mgh.harvard.edu ) Vertebrate gastrulation events form the three...

.../Tolloid activity is required for patterning ventral tissues of the tail: the ventral fin, and the ventroposterior somites and vasculature. Gene expression studies show that mfn mutants exhibit reduced expression of ventrally restricted markers at the end of gastrulation, suggesting that the loss...

... ), a gene essential for notochord development. In flh mutants, cells in the notochord domain generate clones of muscle cells. In contrast, notochord domain cells form mesenchyme in embryos mutant for no tail ( ntl ; zebrafish homologue of Brachyury ). A minority of cells in the notochord domain in wild-type...

...Abigail S. Tucker; Jonathan M. W. Slack ABSTRACT A fate map is produced for the Xenopus tail-forming region at the neurula stage by orthotopic grafting of tissue labelled with fluorescein-dextran amine. It is shown that the axial tissues of the tail are derived from a rectangle 700 μm wide by 600...

... dpc T/T +/+ chimeras exhibit many morpho-logical features of intact T/T mutants. In addition, a dramatic bias of T/T cells towards caudal regions (such as tail and allantois) was observed in all chimeras tested. This is likely to result from accumulation of nascent T/T mesoderm cells with time near...

... to adulthood. The mutant mice had defects in the development of the tail and inner ear that could be correlated with disruption of int-2 expression in the posterior primitive streak and hindbrain or otic vesicle. While the tail phenotype was 100% penetrant, we found that the inner ear phenotype had reduced...