... the absence of TSC/RhebGAP in C. elegans , RHEB-1 likely functions as the principal input into the TORC1 signaling axis. In contrast to other metazoans, we found no evidence that C. elegans TORC1 controls cell size. Unexpectedly, we showed that components of TORC1 signaling are required throughout post...

...Michelle Dragojlovic-Munther; Julian A. Martinez-Agosto The innate plasticity of hematopoietic progenitors is tightly regulated to supply blood cells during normal hematopoiesis and in response to stress or infection. We demonstrate that in the Drosophila lymph gland (LG) the tumor suppressors TSC...

... no competing financial interests. © 2011. mTOR TORC1 Stem cells Rapamycin TSC The ability of cells to respond appropriately to nutrient flux is essential for maintaining energy homeostasis. From yeast to humans, nutrient deprivation activates a highly conserved cellular program...