...) as a direct NF-κB target gene, loss of which replicates a subset of phenotypes seen in NF-κB-deficient embryos. Lhx2 and Tgfb2 knockout embryos exhibit very similar abnormalities in HF development, including failure of the E-cadherin suppression required for follicle down-growth. We show that TGFβ2 signaling...

... properties. Preadsorption of CM Cerebellum with antisera against candidate cytokines showed that TGFβ2 and BDNF could account for the major part of the anti-proliferative and pro-differentiating activities, an interpretation strengthened by studies involving treatment with purified TGFβ2 and BDNF...

... in apoptosis as assessed by both TUNEL labeling in paraffin sections and caspase activity in trypsin-dispersed hearts. Additionally, E12.5 embryos demonstrated elevated levels of transforming growth factor β2 (TGFβ2) protein in multiple cell lineages in the heart. Using a whole-mouse-embryo culture system...

... December 2000 © 2001 by Company of Biologists 2001 Induction Kidney Tubulogenesis Wnt signaling Stat TGFβ2 LIF FGF2 Rat From the classical studies of biologists such as Lewis, Spemann and Mangold, it has long been recognized that tissue differentiation is mediated by factors...

...L. Philip Sanford; Ilona Ormsby; Adriana C. Gittenberger-de Groot; Hannu Sariola; Rick Friedman; Gregory P. Boivin; Emma Lou Cardell; Thomas Doetschman ABSTRACT The growth and differentiation factor transforming growth factor-β2 (TGFβ2) is thought to play important roles in multiple developmental...