...://www.biologists.com/user-licence-1-1/ Summary: A novel nuclear inhibitor holds Tcf7l1 in a transcriptional inhibitory state and promotes silencing of Wnt target genes. Organizer Groucho/Tle Tcf/Lef Barhl2 Hdac Stem cells Wnt Pluripotency Transcription References Abramoff , M. D...

... . Functional and epistatic studies showed that GPX4 functions at the Tcf/Lef level, independently of selenocysteine activation. Mechanistically, GPX4 interacts with Tcf/Lefs and inhibits Wnt activity by preventing the binding of Tcf/Lefs to the promoters of Wnt target genes, resulting in inhibitory action...

... and LaBonne, 2006 ; Steventon et al., 2009 ; Taneyhill and Bronner-Fraser, 2005 ; Wu et al., 2005 ). Tcf7l1 was able to significantly reduce the levels of Wnt reporter signal by competing with Tcf7 and Lef1 or by decreasing the pool of free ΔNβ-catenin required for transactivation by the Tcf/Lefs...

... 2006. 2006 NLK Delta TCF/Lef ERK MAP kinase TAK1 Germ layers Mesoderm Endoderm Sea urchin embryo The mesoderm of the sea urchin embryo originates from two populations of precursors, the primary mesenchyme cells (PMCs) and the secondary mesenchyme cells (SMCs), which are both...

... in its intronic sequence and that these multiple FREs comprise Ets-binding and Tcf/Lef-binding motifs that lie in juxtaposition. Functional and physical analyses indicate that signaling pathways of Fgf, Bmp and Wnt are integrated on these FREs to regulate the expression of Xcad3 in the posterior neural...

...-cycle kinetics, overt terminal differentiation or intercellular adhesion, and correlated with stimulation or inhibition of transactivation of a TCF/LEF reporter in basal keratinocytes. We conclude that the elevated level of cytoplasmic β-catenin in those keratinocytes with characteristics of epidermal...