..., develops from a network of Tbx3-expressing precursor cells in the embryonic heart. Genetic inducible fate mapping Cardiac conduction system Sinus node Atrioventricular node Atrioventricular bundle T-box Tbx3 Dysfunction of the cardiac conduction system (CCS) due to gene mutations...

... cell type-specific targets and functions: it acts with SMAD1 to promote mesoderm specification, while in the endoderm it interacts with SMAD2/3. SMAD T-BOX Embryonic stem cells Gastrulation Gene regulatory networks Human The three primary germ layers (ectoderm, mesoderm and endoderm...

...Andrew J. Washkowitz; Caroline Schall; Kun Zhang; Wolfgang Wurst; Thomas Floss; Jesse Mager; Virginia E. Papaioannou The maintenance and control of pluripotency is of great interest in stem cell biology. The dual specificity T-box/basic-helix-loop-helix-zipper transcription factor Mga is expressed...

..., USA Competing interests statement 6 4 2010 © 2010. Tbx20 Cardiogenesis Cardiac Heart Xenopus laevis Xenopus tropicalis SMAD1 SMAD4 T-box BMP Zebrafish Transgenesis A series of clinical studies has provided direct evidence...

... for its function. * Author for correspondence( and2015@med.cornell.edu ) 21 8 2009 © 2009. 2009 Ciona Brachyury FoxA Notochord Muscle Ascidian T-box Cis-regulatory module Transcription The T-box transcription factor Brachyury and members of the FoxA winged-helix...

... indistinguishable from Tbx4 null embryos and died at E10.5 due to failure of chorioallantoic fusion (data not shown). * Author for correspondence (e-mail: vep1@columbia.edu ) 24 10 2006 © 2007. 2007 Tbx4 Hindlimb Limb T-box Tbx5 Fgf10 Mouse Vertebrate limbs consist...

... for correspondence (e-mail: mmercola@burnham.org ) 31 8 2006 © 2006. 2006 Notch Hairy-related transcription factor HRT HES Hey Gridlock Atrioventricular canal T-box Tbx During early embryogenesis, the linear heart [HH stage 10 in the chick( Hamburger and Hamilton,1951 ), E8...

... microscope. * Author for correspondence (e-mail: frank_conlon@med.unc.edu ) 28 4 2006 © 2006. 2006 Tbx5 Holt-Oram Syndrome Cardiogenesis Cardiac Heart Xenopus Cell cycle S-phase Proliferation T-box Hyperplastic growth of the vertebrate heart...

...Steven H. Fong; Alexander Emelyanov; Cathleen Teh; Vladimir Korzh During gastrulation, optimal adhesion and receptivity to signalling cues are essential for cells to acquire new positions and identities via coordinated cell movements. T-box transcription factors and the Wnt signalling pathways...

...Manvendra K. Singh; Vincent M. Christoffels; José M. Dias; Mark-Oliver Trowe; Marianne Petry; Karin Schuster-Gossler; Antje Bürger; Johan Ericson; Andreas Kispert Tbx20 , a member of the T-box family of transcriptional regulators,shows evolutionary conserved expression in the developing heart...

... specification and morphogenesis of the mammalian embryonic heart are poorly understood. We now show by gene targeting that murine T-box transcription factor Tbx20 plays a central role in these pathways, and has important activities in both cardiac development and adult function. Loss of Tbx20 results in death...

... of the T-box transcription factor Tbx20 in mammalian development, we generated a graded loss-of-function series by transgenic RNA interference in entirely embryonic stem cell-derived mouse embryos. Complete Tbx20 knockdown resulted in defects in heart formation, including hypoplasia of the outflow tract...

...Chen-Leng Cai; Wenlai Zhou; Lei Yang; Lei Bu; Yibing Qyang; Xiaoxue Zhang; Xiaodong Li; Michael G. Rosenfeld; Ju Chen; Sylvia Evans Mutations in T-box genes are the cause of several congenital diseases and are implicated in cancer. Tbx20 -null mice exhibit severely hypoplastic hearts and express...

... repressor that belongs to the Tbx2/3/4/5 subfamily of T-box transcriptional regulators, in the forelimb results in a rostral shift in the position of the limb along the main body axis. By contrast, a transcriptional activator form of Tbx3 shifts the limb to more caudal locations. We also show that dHand...

...Daniel D. Brown; Shauna N. Martz; Olav Binder; Sarah C. Goetz; Brenda M. J. Price; Jim C. Smith; Frank L. Conlon Members of the T-box family of proteins play a fundamental role in patterning the developing vertebrate heart; however, the precise cellular requirements for any one family member...

...Zachary Harrelson; Robert G. Kelly; Sarah N. Goldin; Jeremy J. Gibson-Brown; Roni J. Bollag; Lee M. Silver; Virginia E. Papaioannou Tbx2 is a member of the T-box transcription factor gene family,and is expressed in a variety of tissues and organs during embryogenesis. In the developing heart, Tbx2...

... the early cell divisions that diversify the ABa and ABp descendants. The first interaction determines the pattern of ectodermal cell types produced by ABp. The second interaction induces two ABa granddaughters to become mesodermal precursors. We show that T-box transcription factors called TBX-37 and TBX-38...

...Ashley E. E. Bruce; Cristin Howley; Yi Zhou; Sarah L. Vickers; Lee M. Silver; Mary Lou King; Robert K. Ho Early embryonic development in many organisms relies upon maternal molecules deposited into the egg prior to fertilization. We have cloned and characterized a maternal T-box gene...

... of the T-box domain family of transcription factors. All three genes are arranged in a gene cluster, are expressed in identical patterns in embryos, and appear to be genetically redundant. By generating mutants with a loss of all three Dorsocross genes, we demonstrate that Dorsocross gene activity...

...L. A. Naiche; Virginia E. Papaioannou Tbx4 is a member of the T-box family of transcription factor genes, which have been shown to play important roles in development. We have ablated Tbx4 function using targeted mutagenesis in the mouse. Embryos homozygous for the null allele fail to undergo...