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Keywords: T cell
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Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 5 September 2019
... development in the thymus ( Fig. 5 A). Early CD4/CD8 double-negative (DN) T cell progenitors commit to the T cell lineage in the thymus and differentiate from DN1 to DN3T cells in a RUNX1-dependent process ( Ikawa et al., 2004 ; Kawamoto et al., 1999 , 2000 ; Krueger and von Boehmer, 2007 ; Perry et al...
Journal Articles
Journal: Development
Development (2011) 138 (18): 3865–3878.
Published: 15 September 2011
...Julie Gordon; Nancy R. Manley The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1183–1192.
Published: 15 March 2006
..., including hypomethylation of repetitive sequences, low body weight, distinct cranial facial anomalies and T cell death by apoptosis. These results indicate that Dnmt3b plays an essential role at different stages of mouse development, and that ICF missense mutations cause partial loss of function...
Includes: Supplementary data