... in dendrite and synapse formation during development. LRP4 Central nervous system development Synapse formation Dendritogenesis Transsynaptic tracing Agrin In utero electroporation PSD95 Bassoon Mouse During the last few decades we have acquired substantial knowledge on how...

... disorders. The formation of excitatory and inhibitory synapses requires precise molecular control. In the hippocampus, the structure crucial for learning and memory, fibroblast growth factor 22 (FGF22) and FGF7 specifically promote excitatory or inhibitory synapse formation, respectively. Knockout of either...

... governing synaptogenesis at single-cell resolution in the Drosophila CNS. Drosophila Synapse formation Sensory neuron CNS 3D CLEM Developmental synaptogenesis is a complex multifactorial process ( Chia et al., 2013 ; Jin and Garner, 2008 ; Sheng and Kim, 2011 ; Yamagata et al., 2003...

.... Amyloid precursor protein Neural development Axonal outgrowth Synapse formation Alzheimer's disease (AD) is characterized by a progressive degeneration of neurons, which results in cognitive deficiency, behavioral disturbance and neuropsychiatric symptoms ( Adlard and Cummings, 2004 ). AD...

..., but not proprioceptive axons, inhibit synapse formation in Sema6d mutants. Our findings provide new insights into the relationship between oligodendrocytes and synapse formation in vivo, which might be an important element in controlling the development of neural wiring in the central nervous system. † Author...

... Neuromuscular junction Retrograde signaling Synapse formation The brain contains billions of nerve cells, or neurons, which receive and integrate signals from the environment, and which govern the body's responses. Nervous system activity is made possible by synapses, contacts formed either between...

... than do control interneurons ( Weiner et al.,2005 ). These genetic dissociations suggest that at least one primary function of the γ-Pcdhs is to promote synapse formation or maturation in the spinal cord. It has long been known that neuronal survival depends, in most cases, on synaptic activity...

... acetylcholine receptor neuromuscular junction synapse formation mouse At synapses throughout the nervous system, neurotransmitter receptors are concentrated in the postsynaptic membrane. Many of these receptors are hetero-oligomers drawn from large multigene families ( Ortells and Lunt, 1995...

... junction synapse formation During synapse formation at the vertebrate skeletal neuromuscular junction, the motor axon induces the formation of postsynaptic specializations in the muscle fiber ( Hall and Sanes, 1993 ). A crucial signaling molecule in this process is agrin, a heparan sulfate...

... synapse formation agrin proteoglycan dystroglycan heparin A putative muscle cell surface proteoglycan, α-dystroglycan, has been shown to bind agrin ( Bowe et al., 1994 ; Cam-panelli et al., 1994; Gee et al., 1994 ; Sugiyama et al., 1994 ). α-dystroglycan is present at agrin-induced clusters...