... induce death of sensory neurons in vitro . The extent to which Sema3A regulates developmental cell death in vivo , however, is debated. We show that in compartmentalized cultures of rat sympathetic neurons, a Sema3A-initiated apoptosis signal is retrogradely transported from axon terminals to cell bodies...

...-derived axonal guidance cues for developing sympathetic neurons . Nature 452 , 759 - 763 . 10.1038/nature06859 Marquardt T. , Shirasaki R. , Ghosh S. , Andrews S. E. , Carter N. , Hunter T. , Pfaff S. L. ( 2005 ). Coexpressed EphA receptors and ephrin...

... neurite growth and is a receptor for proNGF, we investigated whether it has a role in the neurite growth-promoting effects of proNGF on postnatal sympathetic neurons. We began investigating this question by quantifying the level of p75 NTR transcripts expressed in the SCG over the period of development...

.... Differentiation of sympatho-adrenal precursors, as assessed by the expression of neuronal subtype-specific genes such as Th and Dbh , is delayed in a pronounced manner, which is accompanied by a reduced proliferation. Sympathetic neurons eventually overcome the differentiation blockade and mature correctly...

... chromaffin cells and sympathetic neurons. Additionally, mRNA analyses of purified chromaffin cells from Gata3 mutants show that levels of Mash1, Hand2 and Phox2b(postulated upstream regulators of Gata3) as well as terminally differentiated SA lineage products (tyrosine hydroxylase, Th, and dopamineβ...

... mouse embryos, generated by targeted gene disruption, showed displacement of sympathetic neurons and their precursors and abnormal morphogenesis in the sympathetic trunk. We also show that Sema3A suppressed the cell migration activity of sympathetic neurons from wild-type but not neuropilin 1 mutant...

... fibers of mice carrying one functional copy of the Nt-3 gene ( Nt-3 +/ − mice) invaded the pineal gland, but failed to branch and form a ground plexus. Cultured neonatal sympathetic neurons responded to NT-3 by neurite outgrowth and mRNA upregulation of the NT-3 receptor, trkC. Exogenously administered...

...E. Blaugrund; T. D. Pham; V. M. Tennyson; L. Lo; L. Sommer; D.J. Anderson; M.D. Gershon ABSTRACT Enteric and sympathetic neurons have previously been proposed to be lineally related. We present independent lines of evidence that suggest that enteric neurons arise from at least two lineages, only...

... changes in neuro-transmitter properties in cultured sympathetic neurons that mimic those observed in vivo. We have characterized further the factors present in the extract and com-pared their properties to those of known cholinergic fac-tors. When assayed on cultured rat sympathetic neurons, the major...