... a Notch-dependent, cell fate. In a genome-wide survey for potential Notch pathway targets, the second intron of the numb gene was found to contain a statistically significant cluster of binding sites for Suppressor of Hairless, the transducing transcription factor for the pathway. We show that this region...

... findings indicate that a combination of positive and negative transcriptional inputs program the precise PSC expression of the instructive Hh signal. The GATA factor Serpent (Srp) is essential for hh activation in niche cells, whereas the Suppressor of Hairless [Su(H)] and U-shaped (Ush) transcriptional...

... spatial and temporal interactions between Notch, wingless , and vestigial specify proximal and distal pattern elements of the wing in Drosophila. Dev. Biol. 194 , 196 -212. Klein, T., Seugnet, L., Haenlin, M. and Martinez Arias, A. ( 2000 ). Two different activities of Suppressor of Hairless...

.... Drosophila Mesoderm Muscle Subdivision Signaling Transcriptional regulation Notch Suppressor of Hairless bHLH twist daughterless extra machrochaetae Enhancer of split Early in vertebrate and invertebrate development, uncommitted mesodermal cells are patterned into repetitive...

... the SOP insensitive to Dl. * Author for correspondence (e-mail: th.klein@uni-koeln.de ) 30 1 2003 © 2003. 2003 Suppressor of Hairless Enhancer of split complex Notch-signalling Bristle development Presenilin Kuzbanian Senseless Notch signalling plays a fundamental...

... clonal analysis we show that a ligand of Notch, Delta, is required along with Notch for both proneural enhancement and lateral specification, while the downstream components Suppressor-of-Hairless and Enhancer-of-Split are involved only in lateral specification. Our data point to a distinct signal...

... in the sensory organ lineage. Interestingly, we found that in the hair/socket cell lineage but not the neuron/sheath cell lineage, a Suppressor of Hairless mutation acts as a dominant suppressor of numb mutations whereas Hairless mutations act as enhancers of numb . Moreover, epistasis analysis indicates...

..., Sulta, Osaka 565, Japan 20 08 1997 © 1997 by Company of Biologists 1997 Notch Suppressor of Hairless ankyrin repeats Drosophila The Notch (N) signaling pathway defines an evolutionary conserved cell interaction mechanism that controls the pro-gression of precursor cells...

... 08 1996 © 1996 by Company of Biologists 1996 Notch wingless vestigial cut Distal-less Suppressor of Hairless axis formation morphogen signal transduction limb development Drosophila Studies on the development of Drosophila appendages have indicated...

... of downstream genes. The Suppressor of Hairless protein is the intermediary between Notch activation and expression of all Enhancer of split genes even though individual genes have distinct patterns of expression in imaginal discs. A comparison between the phenotypes produced by Notch, Suppressor of Hairless...

...Michel Gho; Magalie Lecourtois; Gérard Géraud; James W. Posakony; François Schweisguth ABSTRACT During imaginal development of Drosophila , Suppressor of Hairless [Su(H)], an evolutionarily conserved transcription factor that mediates intracellular signalling by the Notch (N) receptor, controls...

...François Schweisguth; James W. Posakony ABSTRACT Successive alternative cell fate choices in the imaginal disc epithelium lead to the differentiation of a relatively invariant pattern of multicellular adult sensory organs in Drosophila . We show here that the activity of Suppressor of Hairless...