... in ventral follicle cells leads to the sulfation of a secreted glycoprotein that is deposited ventrally in the egg, where it mediates the activation of the dorsal group serine protease cascade. If any of the genes that encode proteins involved in the synthesis of the direct carbohydrate target of Pipe or its...

...Mauricio Cortes; Alexis T. Baria; Nancy B. Schwartz In contrast to the functional role of heparan sulfate proteoglycans(HSPGs), the importance of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving hedgehog proteins, wingless-related proteins and fibroblast growth...

... activity of Pipe. Surprisingly, however, our results also indicated that formation of the embryonic DV axis does not require the synthesis of the high-energy sulfate donor, 3′-phosphoadenosine 5′-phosphosulfate(PAPS) in the follicle cells in which Pipe is presumed to function. Here, we resolve...