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Keywords: Stratum
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Journal Articles
Journal: Development
Development (2021) 148 (1): dev191437.
Published: 10 January 2021
... and Stratum regulate the trafficking of Notch and Sanpodo from the trans -Golgi network to the basolateral membrane. Loss of AP-1 or Stratum caused mild Notch gain-of-function phenotypes. Here, we report that their concomitant loss results in a penetrant Notch gain-of-function phenotype, indicating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163469.
Published: 2 July 2018
... by ligand is based on the correct polarized sorting and localization of the Notch ligand Delta, the Notch receptor and its trafficking partner Sanpodo (Spdo). Here, we have identified Stratum (Strat), a presumptive guanine nucleotide exchange factor for Rab GTPases, as a regulator of Notch activation. Loss...
Includes: Supplementary data