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Keywords: Stem cell
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Journal Articles
Journal: Development
Development (2023) 150 (21): dev202169.
Published: 17 October 2023
... between histone modifications and developmental processes is challenging. In this Review, we discuss the use of dominant-negative histone mutations as tractable tools to study histone methylation in development. Chromatin Epigenetics Histone modification Stem cell Differentiation...
Journal Articles
Journal: Development
Development (2023) 150 (17): dev201790.
Published: 11 September 2023
... their development. Primordial germ cell Gastruloid Embryo Stem cell Cell interactions Francis Crick Institute http://dx.doi.org/10.13039/100010438 Cancer Research UK http://dx.doi.org/10.13039/501100000289 CC2186 Medical Research Council http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (12): dev201552.
Published: 26 June 2023
... supporting non-neuronal cell types. Depending on both tissue type and integrity, the Notch signaling pathway can either positively or negatively regulate resident stem cell activity. Although Notch1 specifies HBC dormancy in the uninjured OE, little is known about how HBCs are influenced by the Notch pathway...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (20): dev199961.
Published: 1 June 2023
...William B. Tu; Heather R. Christofk; Kathrin Plath ABSTRACT Diet contributes to health at all stages of life, from embryonic development to old age. Nutrients, including vitamins, amino acids, lipids and sugars, have instructive roles in directing cell fate and function, maintaining stem cell...
Journal Articles
Journal: Development
Development (2023) 150 (2): dev201148.
Published: 20 January 2023
...Phylis Hétié; Margaret de Cuevas; Erika L. Matunis ABSTRACT The adult Drosophila testis contains a well-defined niche created by a cluster of hub cells, which secrete signals that maintain adjacent germline stem cells and somatic cyst stem cells (CySCs). Hub cells are normally quiescent in adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201015.
Published: 18 October 2022
... of scientists due to ethical and practical limitations. Thankfully, pluripotent stem cells that resemble early developmental cell types possess the ability to mimic specific embryonic events. As such, murine and human stem cells have been leveraged by scientists to create in vitro models that aim...
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev201203.
Published: 17 October 2022
...., 1997 ). PDL tissue attached to extracted human teeth has been analyzed extensively, and PDL stem cells (PDLSCs) with minimal stemness criteria ( Mao et al., 2012 ), including in vitro differentiation capacity to osteoblasts and ectopic bone formation by transplantation assays, have been widely used...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (5): dev200149.
Published: 7 March 2022
... oogenesis using the model insect Drosophila melanogaster . In adult females maintained at 18°C (cold) or 29°C (warm), relative to females at the 25°C control temperature, egg production was reduced through distinct cellular mechanisms. Chronic 18°C exposure improved germline stem cell maintenance, survival...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200033.
Published: 14 February 2022
... cord regeneration. Here, using RNA-seq analysis, we discovered that the inhibition of miR-200a results in an upregulation of the classical mesodermal marker brachyury in spinal cord cells after injury. However, these cells still express the neural stem cell marker sox2 . In vivo cell tracking allowed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev194936.
Published: 10 November 2021
... using BioRender.com. DRG, dorsal root ganglion; eEAN, extrinsic enteric-associated neurons; ENS, enteric nervous system; ISC, intestinal stem cells. At the time of birth or hatching, animals become exposed to new sources of microbes in their respective environments that can subsequently colonize...
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199750.
Published: 14 October 2021
..., suggesting the mechanisms underlying these processes differ between the sexes. One example of a sex difference in organ homeostasis and repair emerges from studies on intestinal stem cells (ISC) in the Drosophila melanogaster gut ( Ahmed et al., 2020 ; Hudry et al., 2016 ; Regan et al., 2016...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
...Christa Buecker; Florian T. Merkle ABSTRACT The third ‘Symposium for the Next Generation of Stem Cell Research’ (SY-Stem) was held virtually on 3-5 March 2021, having been cancelled in 2020 due to the COVID-19 pandemic. As in previous years, the meeting highlighted the work of early career...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev196675.
Published: 15 June 2021
...Laura Currey; Stefan Thor; Michael Piper ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 9 March 2021
... in Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (20): dev173377.
Published: 25 October 2019
... polymerase II-dependent transcriptional processes. We found that the control of flower termination was not as robust as classically pictured. In angiosperms, the floral female organs, called carpels, display determinate growth: their development requires the arrest of stem cell maintenance. In vip3 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
... rule . Nature   533 , 169 - 171 . 10.1038/533169a International Society of Stem Cell Research . ( 2016 ). Guidelines for Stem Cell Research and Clinical Translation . International Society for Stem Cell Research . Kimmel , C. B. , Warga , R. M. and Schilling , T. F. ( 1990...
Includes: Supplementary data
Journal Articles