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Keywords: Stem cell
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Journal Articles
Journal: Development
Development (2021) 148 (21): dev194936.
Published: 10 November 2021
... © 2021. Published by The Company of Biologists Ltd 2021 Enteroendocrine cell Gastroenterology Gut-brain axis Interoception Microbiome Stem cell National Institutes of Health http://dx.doi.org/10.13039/100000002 K01-DK125527 R01-DK111857 R24-OD016761 R24-DK110492 R01...
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199750.
Published: 14 October 2021
... organ formation, function and whole-body physiology. Together, the examples we highlight show that one simple way to gain a more accurate and comprehensive understanding of animal development is to include both sexes. Beyond considerations of donor sex in stem cell studies, both sexes must also...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
...Christa Buecker; Florian T. Merkle ABSTRACT The third ‘Symposium for the Next Generation of Stem Cell Research’ (SY-Stem) was held virtually on 3-5 March 2021, having been cancelled in 2020 due to the COVID-19 pandemic. As in previous years, the meeting highlighted the work of early career...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev196675.
Published: 15 June 2021
...Laura Currey; Stefan Thor; Michael Piper ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 09 March 2021
... in Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
.../17064 Baghdadi , M. B. , Castel , D. , Machado , L. , Fukada , S.-I. , Birk , D. E. , Relaix , F. , Tajbakhsh , S. and Mourikis , P. ( 2018 ). Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche . Nature   557 , 714 - 718...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev173377.
Published: 25 October 2019
... polymerase II-dependent transcriptional processes. We found that the control of flower termination was not as robust as classically pictured. In angiosperms, the floral female organs, called carpels, display determinate growth: their development requires the arrest of stem cell maintenance. In vip3 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
...-days ex vivo , the time when the PS first appears ( Hyun et al., 2016 ; International Society of Stem Cell Research, 2016 ; Deglincerti et al., 2016 ). A map of the gastrulating human embryo, however, could be incredibly useful not only for comparison with model organisms and for understanding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev161885.
Published: 10 May 2019
...Samip R. Bhattarai; Salma Begum; Rachel Popow; Ellen J. Ezratty ABSTRACT Arl/ARF GTPases regulate ciliary trafficking, but their tissue-specific functions are unclear. Here, we demonstrate that ciliary GTPase Arl3 is required for mitotic spindle orientation of mouse basal stem cells during skin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev166074.
Published: 16 April 2019
...Xuyu Qian; Hongjun Song; Guo-li Ming ABSTRACT Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used...
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
...Iain Martyn; Ali H. Brivanlou; Eric D. Siggia ABSTRACT Long-range signaling by morphogens and their inhibitors define embryonic patterning yet quantitative data and models are rare, especially in humans. Here, we use a human embryonic stem cell micropattern system to model formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev151894.
Published: 14 March 2019
... adaptation to stress. In this Review, we summarize our current knowledge of the spatiotemporal control of BR action in plant growth and development, focusing on BR functions in primary root development and growth, in stem cell self-renewal and death, and in plant adaption to environmental stress. Summary...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171520.
Published: 01 February 2019
... that microbial-induced ROS generation within Drosophila larval stem cell compartments exhibits a distinct spatial distribution. Lactobacilli-induced ROS is strictly excluded from defined midgut compartments that harbor adult midgut progenitor (AMP) cells, forming a functional ‘ROS sheltered zone’ (RSZ). The RSZ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 01 February 2019
... ). Likewise, we will not discuss the consequences of Notch alterations in human disease, but refer the reader to other reviews on these topics ( Mašek and Andersson, 2017 ; Siebel and Lendahl, 2017 ). Cell fate Notch Patterning Signaling Stem cell Summary: Notch receptors relay...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev158352.
Published: 10 December 2018
... branching uses interacting transcriptional regulators to fine-tune the spatiotemporal expression of STM and, thus, to precisely regulate axillary meristem initiation. Axillary meristem Branching Stem cell Transcription Arabidopsis In contrast to animals, plants are sessile organisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169136.
Published: 05 December 2018
..., and these non-steroidogenic cells serve as potential ALC stem cells. We generated FLC lineage-specific Nr5a1 ( Ad4BP/SF-1 ) gene-disrupted mice and mice lacking the fetal Leydig enhancer (FLE) of the Nr5a1 gene. Phenotypes of these mice support the conclusion that most of the ALCs arise from dedifferentiated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev167197.
Published: 25 October 2018
.... , Tripathi , P. V. , Steeper , K. M. and Rando , T. A. ( 2012 ). Notch signaling is necessary to maintain quiescence in adult muscle stem cells . Stem Cells   30 , 232 - 242 . 10.1002/stem.773 Brack , A. S. , Bildsoe , H. and Hughes , S. M. ( 2005 ). Evidence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev165795.
Published: 01 October 2018
... and nutrient homeostasis. Recently developed human intestinal organoid models include EECs, but their rarity makes it difficult to study their formation and function. Here, we used the EEC-inducing property of the transcription factor NEUROG3 in human pluripotent stem cell-derived human intestinal organoids...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev163485.
Published: 15 August 2018
... that the original work is properly attributed. Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field. Bronchi Alveolar ESC iPSC Progenitor Stem cell Lung...
Includes: Supplementary data