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Keywords: Stem cell
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Journal Articles
Journal: Development
Development (2023) 150 (2): dev201148.
Published: 20 January 2023
...Phylis Hétié; Margaret de Cuevas; Erika L. Matunis ABSTRACT The adult Drosophila testis contains a well-defined niche created by a cluster of hub cells, which secrete signals that maintain adjacent germline stem cells and somatic cyst stem cells (CySCs). Hub cells are normally quiescent in adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (24): dev200988.
Published: 21 December 2022
...Anish Dattani; Tao Huang; Corin Liddle; Austin Smith; Ge Guo ABSTRACT Propagation of human naïve pluripotent stem cells (nPSCs) relies on the inhibition of MEK/ERK signalling. However, MEK/ERK inhibition also promotes differentiation into trophectoderm (TE). Therefore, robust self-renewal requires...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2022) 149 (20): dev201015.
Published: 18 October 2022
... of scientists due to ethical and practical limitations. Thankfully, pluripotent stem cells that resemble early developmental cell types possess the ability to mimic specific embryonic events. As such, murine and human stem cells have been leveraged by scientists to create in vitro models that aim...
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev201203.
Published: 17 October 2022
... and isolate the periodontal ligament fibroblast lineage, revealing the role of periodontal ligament cells in tissue homeostasis and repair. Periodontal tissue Alveolar bone Periodontal ligament Extracellular matrix Progenitor cell Stem cell Mural cell Single-cell analysis Cell atlas Wound...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (19): dev200787.
Published: 29 September 2022
...Thai Q. Dao; Naama Weksler; Hannah M.-H. Liu; Samuel Leiboff; Jennifer C. Fletcher ABSTRACT The ability of plants to grow and form organs throughout their lifetime is dependent on their sustained stem cell activity. These stem cell populations are maintained by intricate networks of intercellular...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (5): dev200149.
Published: 7 March 2022
... oogenesis using the model insect Drosophila melanogaster . In adult females maintained at 18°C (cold) or 29°C (warm), relative to females at the 25°C control temperature, egg production was reduced through distinct cellular mechanisms. Chronic 18°C exposure improved germline stem cell maintenance, survival...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200033.
Published: 14 February 2022
... cord regeneration. Here, using RNA-seq analysis, we discovered that the inhibition of miR-200a results in an upregulation of the classical mesodermal marker brachyury in spinal cord cells after injury. However, these cells still express the neural stem cell marker sox2 . In vivo cell tracking allowed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev194936.
Published: 10 November 2021
... Amcheslavsky , A. , Jiang , J. and Ip , Y. T. ( 2009 ). Tissue damage-induced intestinal stem cell division in Drosophila . Cell Stem Cell 4 , 49 - 61 . 10.1016/j.stem.2008.10.016 Amcheslavsky , A. , Song , W. , Li , Q. , Nie , Y. , Bragatto , I. , Ferrandon...
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199750.
Published: 14 October 2021
... molecular, cellular, organ-level and organismal mechanisms. Sex difference Cell death Cell proliferation Stem cell Organ homeostasis Cell signaling Canadian Institutes for Health Research PJT-153072 GS4-171365 Natural Sciences and Engineering Research Council of Canada...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev188367.
Published: 25 June 2021
...Christa Buecker; Florian T. Merkle ABSTRACT The third ‘Symposium for the Next Generation of Stem Cell Research’ (SY-Stem) was held virtually on 3-5 March 2021, having been cancelled in 2020 due to the COVID-19 pandemic. As in previous years, the meeting highlighted the work of early career...
Journal Articles
Journal: Development
Development (2021) 148 (12): dev196675.
Published: 15 June 2021
...Laura Currey; Stefan Thor; Michael Piper ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 9 March 2021
... in Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
.... , Castel , D. , Machado , L. , Fukada , S.-I. , Birk , D. E. , Relaix , F. , Tajbakhsh , S. and Mourikis , P. ( 2018 ). Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche . Nature   557 , 714 - 718 . 10.1038/s41586-018-0144-9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev173377.
Published: 25 October 2019
... polymerase II-dependent transcriptional processes. We found that the control of flower termination was not as robust as classically pictured. In angiosperms, the floral female organs, called carpels, display determinate growth: their development requires the arrest of stem cell maintenance. In vip3 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
... for the human primitive streak. Fate map Gastruloid Human Migration Primitive streak Stem cell During amniote gastrulation a symmetrical sheet of identical cells rapidly transforms itself into a multi-layered structure with distinct cell fates and an anterior-posterior axis ( Solnica-Krezel...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev161885.
Published: 10 May 2019
...Samip R. Bhattarai; Salma Begum; Rachel Popow; Ellen J. Ezratty ABSTRACT Arl/ARF GTPases regulate ciliary trafficking, but their tissue-specific functions are unclear. Here, we demonstrate that ciliary GTPase Arl3 is required for mitotic spindle orientation of mouse basal stem cells during skin...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (8): dev166074.
Published: 16 April 2019
...Xuyu Qian; Hongjun Song; Guo-li Ming ABSTRACT Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used...
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
...Iain Martyn; Ali H. Brivanlou; Eric D. Siggia ABSTRACT Long-range signaling by morphogens and their inhibitors define embryonic patterning yet quantitative data and models are rare, especially in humans. Here, we use a human embryonic stem cell micropattern system to model formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev151894.
Published: 14 March 2019
... adaptation to stress. In this Review, we summarize our current knowledge of the spatiotemporal control of BR action in plant growth and development, focusing on BR functions in primary root development and growth, in stem cell self-renewal and death, and in plant adaption to environmental stress...