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Keywords: Sprouty
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Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (10): dev196089.
Published: 17 May 2021
....21150 Casci , T. , Vinós , J. and Freeman , M. ( 1999 ). Sprouty, an intracellular inhibitor of Ras signaling . Cell 96 , 655 - 665 . 10.1016/S0092-8674(00)80576-0 Cebrià , F. , Kobayashi , C. , Umesono , Y. , Nakazawa , M. , Mineta , K. , Ikeo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev173575.
Published: 10 May 2019
... induces and patterns the frog left-right organizer in the early gastrula and regulates the morphogenesis of the flow sensor following specification of the precursor tissue. FGF Pkd2 Sprouty Left-right asymmetry Leftward flow LRO Left-right (LR) asymmetry of inner organs is present...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 63–72.
Published: 1 January 2014
... by Wnt is crucial for regulating FGF activity. We tested Sprouty genes as mediators of this regulatory loop using conditional mouse knockouts and pharmacological manipulations in zebrafish. These reveal that Sprouty genes direct the positioning of early midbrain neurons and are Wnt responsive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3456–3466.
Published: 15 September 2012
... ligands and downstream reporter genes are expressed in highly regionalised patterns in the third pouch and that sprouty gene deletion results in upregulated FGF signalling throughout the pouch endoderm. As a consequence, the initiation of markers of parathyroid and thymus fate is altered. In addition...
Journal Articles
Journal: Development
Development (2011) 138 (23): 5099–5112.
Published: 1 December 2011
... function is dependent on RAS and PI3K signaling but not ERK. In vivo, RAS inactivation by expression of sprouty 1 ( Spry1 ) in CITED1 + nephron progenitors results in loss of characteristic molecular marker expression and in increased death of progenitor cells. Lineage tracing shows that surviving Spry1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2957–2968.
Published: 15 July 2011
... of this pathway during the establishment of the cerebellar territory during early embryogenesis, the role of this pathway during later developmental stages is still poorly understood. Here, we investigated the function of sprouty genes ( Spry1, Spry2 and Spry4 ), which encode feedback antagonists of FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4005–4015.
Published: 1 December 2010
... and migration. Axonal branching, however, is a unicellular process that is mediated by changes in cell shape alone and as such appears very different to multicellular branching. Sprouty (Spry) family members are well-characterised negative regulators of Receptor tyrosine kinase (RTK) signalling. Knockout...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (7): 1085–1093.
Published: 1 April 2010
... by Shp2 positively at the transcriptional level and negatively at the post-translational level. Only in the absence of Sprouty2 could activated Kras signaling robustly rescue the lens proliferation and lacrimal-gland-budding defects in the Shp2 mutants. We propose that the dynamic regulation of Sprouty...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2903–2911.
Published: 1 September 2009
... provided by the intracellular inhibitors of EGFR signaling, Kekkon-1 and Sprouty, control the number and position of Broad-expressing cells and in this way influence eggshell morphology. Later in oogenesis, the gradient of EGFR activation is split into two smaller domains in a process that depends on Argos...
Journal Articles
Journal: Development
Development (2008) 135 (5): 889–898.
Published: 1 March 2008
... Midbrain Cerebellum Sprouty Apoptosis Vermis Roof plate Remarkable progress has been made in understanding how the development of anatomically and functionally distinct subdivisions of the vertebrate brain is controlled. Midbrain and cerebellum formation has been particularly well studied...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 353–365.
Published: 15 January 2008
... of the stomodeum. We identified several genes acting downstream of fgfA in these processes, including the transcription factors pea3 and pax2/5/8 and the signaling molecule sprouty in the lateral ectoderm and SM30 and SM50 in the primary mesenchyme cells. This study identifies the FGF signaling pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (2): 257–265.
Published: 15 January 2005
...: Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA 12 11 2004 ©2005. 2005 Fgf8 Chick Sprouty Isthmus Fgf8 is expressed in the isthmus and acts...
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (25): 6175–6185.
Published: 22 December 2003
...-mail: joyner@saturn.med.nyu.edu ) 28 8 2003 © The Company of Biologists Limited 2003 2003 Fgf8 Fgf17 Fgf18 Mid/hindbrain organizer FGF receptors Sprouty Mouse Chick Early patterning of the vertebrate presumptive midbrain and rhombomere 1(r1), which dorsally gives rise...
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (18): 4139–4147.
Published: 15 September 1999
...Aderet Reich; Amir Sapir; Ben-Zion Shilo ABSTRACT Sprouty was originally identified as an inhibitor of Drosophila FGF receptor signaling during tracheal development. By following the capacity of ectopic Sprouty to abolish the pattern of activated MAP kinase in embryos, we show that Sprouty can...
Journal Articles
Journal: Development
Development (1999) 126 (11): 2515–2525.
Published: 1 June 1999
... of these factors that controls the differential behavior of the responding cells. Here we describe the role of Sprouty in eye development. Sprouty is an extracellular protein that has been shown to antagonize FGF signaling during tracheal branching in Drosophila . It is a novel type of protein with a highly...