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Keywords: Spina bifida
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Journal Articles
Journal: Development
Development (2023) 150 (14): dev201630.
Published: 13 July 2023
... in hindgut extension into the tail bud likely results in the significant increase in the curvature of the tail bud, leading to spina bifida in Tmem132a mutants. Fig. 3. Hindgut extension defects in Tmem132a mutants. (A) Lateral views of E9.5 wild type and Tmem132a mutant embryos processed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (17): dev200442.
Published: 30 August 2022
... mesodermal cell migration during spinal neural tube closure, disruption of which may lead to spina bifida. References Biris , K. K. and Yamaguchi , T. P. ( 2014 ). Two-color in situ hybridization of whole-mount mouse embryos . Methods Mol. Biol. 1092 , 17 - 30 . 10.1007/978-1-60327...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (4): 552–566.
Published: 15 February 2017
...://www.biologists.com/user-licence-1-1/ Summary: This Review discusses the cellular, molecular and biomechanical mechanisms involved in neural tube closure, focusing on the most recent advances in the field. Neural tube Neurulation Neural tube defects Spina bifida Planar cell polarity Convergent...
Journal Articles
Journal: Development
Development (2014) 141 (1): 148–157.
Published: 1 January 2014
... embryos represses the expression of the homeobox-containing genes Pax3 and Cdx2 at the dorsal posterior neuropore (PNP), and subsequently diminishes the expression of the Wnt/β-catenin signaling target genes T, Tbx6 and Fgf8 at the tail bud, leading to spina bifida aperta, caudal axis bending and tail...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2003) 130 (7): 1449–1459.
Published: 1 April 2003
... in the adjacent trunk tissues by RALDH2, and that Cyp26a1 -null animals exhibit spina bifida and caudal agenesis. We now show that, in the absence of Cyp26a1 , retinoic acid receptor gamma (RARγ) mediates ectopic RA-signaling in the tail bud. We also show that activated RARγ results in downregulation of Wnt3a...
Journal Articles
Journal: Development
Development (1999) 126 (11): 2495–2503.
Published: 1 June 1999
... ( Tremblay et al., 1998 ). Transgenic expression of Pax3 in neural tube and neural crest also resulted in the correction of spina bifida and the development of histologically normal dorsal root ganglia. Neural tube closure is a complex process affected by multiple genes and environmental factors...
Journal Articles
Journal: Development
Development (1998) 125 (5): 857–867.
Published: 1 March 1998
...@ohsu.edu ) 10 12 1998 04 02 1998 © 1998 by Company of Biologists 1998 Smad8 BMP Neuralization TGF-β Spina bifida Members of the transforming growth factor-β (TGF-β) family of cell-cell signaling molecules play critical roles in specifying cell fate during embryogenesis...
Journal Articles
Journal Articles
Journal: Development
Development (1990) 110 (1): 229–237.
Published: 1 September 1990
... – 98 . * Author for correspondence 06 06 1990 © 1990 by Company of Biologists 1990 mouse Loop-tail mutant neural tube defects craniorachischisis spina bifida Neurulation occurs with elevation of the lateral margins of the neural plate, which approach each...
Journal Articles
Journal: Development
Development (1990) 108 (1): 73–81.
Published: 1 January 1990
...Ajit J. Alles; Kathleen K. Sulik ABSTRACT Treatment of C57B1/6J mice with three successive doses of all-trans retinoic acid (28 mg kg -1 body weight) on 8 day, 6h (8d,6h), 8d,12h, and 8d,18h of gestation resulted in a high incidence (79%, 31/39 fetuses) of spina bifida with myeloschisis (spina...
Journal Articles