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Keywords: Spermatogonia
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (22): dev200713.
Published: 16 November 2022
...Oleksandr Kirsanov; Taylor Johnson; Taylor Malachowski; Bryan A. Niedenberger; Emma A. Gilbert; Debajit Bhowmick; P. Hande Ozdinler; Douglas A. Gray; Kelsey Fisher-Wellman; Brian P. Hermann; Christopher B. Geyer ABSTRACT In mammalian testes, premeiotic spermatogonia respond to retinoic acid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184655.
Published: 12 April 2020
... and progenitors. Here, using mouse models, we explored the role of RNA-binding proteins (RBPs) in regulation of the biological activities of this population. Proteins bound to polyadenylated RNAs in primary cultures of undifferentiated spermatogonia were captured with oligo (dT)-conjugated beads after UV...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180273.
Published: 6 November 2019
... elevated kinase activity, which underlies these differentiation defects. Our results demonstrate that precise regulation of CDK2 kinase activity in male germ cell development is crucial for the gonocyte-to-spermatogonia transition and long-term spermatogenic homeostasis. As an orthogonal assessment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173088.
Published: 13 May 2019
... as stem cells (self-renewal) or proliferate and differentiate to enter meiosis in response to retinoic acid (RA). Here, we sought to uncover elusive mechanisms regulating a key switch fundamental to spermatogonial fate: the capacity of spermatogonia to respond to RA. Using the developing mouse testis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev174953.
Published: 27 March 2019
... to assign cells to distinct cell states in the developmental continuum. We defined the unique transcriptional programs underlying migratory capacity, resting cellular states and apoptosis regulation in transitional gonocytes. We also identified a subpopulation of primitive spermatogonia marked by CD87...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169102.
Published: 30 November 2018
.... A. and Collas , P. ( 2008 ). A rapid micro chromatin immunoprecipitation assay (microChIP) . Nat. Protoc.   3 , 1032 - 1045 . 10.1038/nprot.2008.68 de Rooij , D. G. and Russell , L. D. ( 2000 ). All you wanted to know about spermatogonia but were afraid to ask . J. Androl.   21 , 776...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2018) 145 (15): dev161323.
Published: 13 August 2018
... products. In addition to ICBs, spermatogonia exhibit multiple thin cytoplasmic projections. Here, we have explored the nature of these projections in mice and find that they are dynamic, span considerable distances from their cell body (≥25 μm), either terminate or physically connect multiple adjacent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3430–3439.
Published: 1 October 2017
.... Despite this crucial role, the molecular signature, kinetic behavior and regulation of human spermatogonia are poorly understood. Using human testis biopsies with normal spermatogenesis and by studying marker protein expression, we have identified for the first time different subpopulations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3022–3030.
Published: 1 September 2017
... Spermatogonia Spermatogonial stem cells Stem cells Spermatogenesis, the process that generates spermatozoa (mature male gametes), takes place in the wall of the seminiferous tubules and involves a multitude of sequential cell types ( Fig. 1 ). First, there are undifferentiated spermatogonia, among...
Journal Articles
Journal: Development
Development (2017) 144 (4): 624–634.
Published: 15 February 2017
... the stem cell to the immediate progenitor state requires downregulation of Id4 coincident with a major change in the transcriptome. Collectively, our results demonstrate that the level of ID4 is predictive of stem cell or progenitor capacity in spermatogonia and dictates the interface of transition between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1582–1592.
Published: 1 May 2015
..., the mechanisms that operate in mouse spermatogenesis are unknown because undifferentiated spermatogonia (A undiff ) are motile and intermingle with differentiating cells in an ‘open’ niche environment of seminiferous tubules. A undiff include glial cell line-derived neurotrophic factor receptor α1 (GFRα1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4298–4310.
Published: 15 November 2014
... isoforms and presumably binds to DNA. Within the male germ cell lineage, BNC2 is restricted to prospermatogonia and undifferentiated spermatogonia. Fetal prospermatogonia that lack BNC2 multiply excessively on embryonic day (E)14.5 and reenter the cell cycle prematurely. Mutant prospermatogonia also engage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1734–1743.
Published: 15 May 2012
.... ( 2000 ). All you wanted to know about spermatogonia but were afraid to ask . J. Androl. 21 , 776 – 798 . Goriely A. , McVean G. A. , van Pelt A. M. , O’Rourke A. W. , Wall S. A. , de Rooij D. G. , Wilkie A. O. ( 2005 ). Gain-of-function amino acid...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3367–3376.
Published: 15 August 2011
... by detaching from the hub. Following starvation-induced GSC loss, GSC numbers are restored by symmetric renewals. Furthermore, upon more severe (genetically induced) GSC loss, both symmetric renewal and de-differentiation (where interconnected spermatogonia fragment into pairs while moving towards...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (1): 117–122.
Published: 1 January 2005
..., and the maturation process, from epiblast cells through PGCs to postnatal spermatogonia, can occur in the postnatal testicular environment. Primordial germ cell transplantation techniques will also provide a novel tool to assess the developmental potential of PGCs, such as those manipulated in vitro or recovered...
Journal Articles
Journal: Development
Development (2002) 129 (14): 3359–3365.
Published: 15 July 2002
... cells alone, indicating that the feeder cells stimulate proliferation of spermatogonia. When cultured germ cells/sperm with the feeders were used for in vitro fertilization, normal embryos were obtained. Addition of the thymidine analogue 5-bromo-2′-deoxyuridine (BrdU) into culture medium resulted...
Journal Articles
Journal: Development
Development (1985) 85 (1): 1–19.
Published: 1 February 1985
...-haematoxylin-stained testicular sections, with the following results: 1) in subfertile males there is a depletion of spermatogonia in the regenerating compartment but their differentiation is not affected. In the sterile males there is degeneration of primary and secondary spermatocytes and massive spermatid...