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1-20 of 105
Keywords: Spermatogenesis
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Journal Articles
Lisa Shao, Jaclyn M. Fingerhut, Brook L. Falk, Hong Han, Giovanna Maldonado, Yuemeng Qiao, Vincent Lee, Elizabeth Hall, Liang Chen, Gordon Polevoy, Greco Hernández, Paul Lasko, Julie A. Brill
Journal:
Development
Development dev.200477.
Published: 25 January 2023
... individualization by promoting local accumulation of the E3 ubiquitin ligase inhibitor Soti. Our results further extend the diversity of non-canonical eIF4Es that carry out distinct spatiotemporal roles during spermatogenesis. * Present address: Clarivate Analytics, 150 King St. W, Toronto, Ontario, M5H 1J9...
Journal Articles
Journal:
Development
Development (2023) 150 (2): dev201148.
Published: 20 January 2023
.... Summary: Non-dividing niche cells in the adult Drosophila testis, which are able to divide to replace missing stem cells, are unable to replace themselves. Stem cell Niche Spermatogenesis Cell ablation GeneSwitch Johns Hopkins University http://dx.doi.org/10.13039/100007880...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Oleksandr Kirsanov, Taylor Johnson, Taylor Malachowski, Bryan A. Niedenberger, Emma A. Gilbert, Debajit Bhowmick, P. Hande Ozdinler, Douglas A. Gray, Kelsey Fisher-Wellman, Brian P. Hermann, Christopher B. Geyer
Journal:
Development
Development (2022) 149 (22): dev200713.
Published: 16 November 2022
... of spermatogonia, the majority of models in the literature come with limitations, including expression of fluorophores in only a subset of spermatogonia (e.g. SSCs and early progenitors during the first wave of spermatogenesis; Chan et al., 2014 ; Helsel et al., 2017 ) or infrequency of genetically appropriate...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2022) 149 (10): dev200229.
Published: 30 May 2022
... characterize two suppressors of memi-1(sb41) : gskl-1 and gskl-2 . Both genes encode functionally redundant sperm glycogen synthase kinase, type 3 (GSK3) protein kinases. Loss of both genes causes defects in male spermatogenesis, sperm pseudopod treadmilling and paternal-effect embryonic lethality. The two...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2022) 149 (1): dev200089.
Published: 10 January 2022
.... , Keeney , S. , Flaus , A. , Owen-Hughes , T. et al. ( 2013 ). Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis . PLoS Genet. 9 , e1003945 . 10.1371/journal.pgen.1003945 Gévry , N...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Jian Chen, Chenxu Gao, Xiwen Lin, Yan Ning, Wei He, Chunwei Zheng, Daoqin Zhang, Lin Yan, Binjie Jiang, Yuting Zhao, Md Alim Hossen, Chunsheng Han
Journal:
Development
Development (2021) 148 (24): dev199799.
Published: 16 December 2021
...Jian Chen; Chenxu Gao; Xiwen Lin; Yan Ning; Wei He; Chunwei Zheng; Daoqin Zhang; Lin Yan; Binjie Jiang; Yuting Zhao; Md Alim Hossen; Chunsheng Han ABSTRACT Spermatogonial differentiation and meiotic initiation during spermatogenesis are tightly regulated by a number of genes, including those...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Siyu Liu, Jintao Zhang, Zine Eddine Kherraf, Shuya Sun, Xin Zhang, Caroline Cazin, Charles Coutton, Raoudha Zouari, Shuqin Zhao, Fan Hu, Selima Fourati Ben Mustapha, Christophe Arnoult, Pierre F. Ray, Mingxi Liu
Journal:
Development
Development (2021) 148 (23): dev199805.
Published: 7 December 2021
... and for axoneme stability, and is therefore crucial for spermatogenesis. Cilia Flagella MMAF Spermatogenesis Male infertility Radial spoke CSC National Key Research and Development Program of China 2016YFA0500902 Natural Science Foundation of China http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2021) 148 (21): dev199644.
Published: 29 October 2021
... acrosome biogenesis in spermatogenesis have been well described, the molecular mechanism underlying this process is still largely unknown. Family with sequence similarity 71, member F1 and F2 (FAM71F1 and FAM71F2) are testis-enriched proteins that contain a RAB2B-binding domain, a small GTPase involved...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Na Liu, Fatimunnisa Qadri, Hauke Busch, Stefanie Huegel, Gabin Sihn, Ilya Chuykin, Enno Hartmann, Michael Bader, Franziska Rother
Journal:
Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
...Na Liu; Fatimunnisa Qadri; Hauke Busch; Stefanie Huegel; Gabin Sihn; Ilya Chuykin; Enno Hartmann; Michael Bader; Franziska Rother ABSTRACT Spermatogenesis is driven by an ordered series of events, which rely on trafficking of specific proteins between nucleus and cytoplasm. The karyopherin α family...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Rudolf Gilmutdinov, Eugene N. Kozlov, Konstantin V. Yakovlev, Ludmila V. Olenina, Alexei A. Kotov, Justinn Barr, Mariya Zhukova, Paul Schedl, Yulii V. Shidlovskii
Journal:
Development
Development (2021) 148 (17): dev198788.
Published: 9 September 2021
... in Drosophila , Orb2, is a principal player in spermatogenesis. It is required for meiosis and spermatid differentiation. During the later process, orb2 mRNA and protein are localized within the developing spermatid. To evaluate the role of the orb2 mRNA 3′UTR in spermatogenesis, we used the CRISPR/Cas9 system...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Grigor Varuzhanyan, Mark S. Ladinsky, Shun-ichi Yamashita, Manabu Abe, Kenji Sakimura, Tomotake Kanki, David C. Chan
Journal:
Development
Development (2021) 148 (16): dev199686.
Published: 12 August 2021
...Grigor Varuzhanyan; Mark S. Ladinsky; Shun-ichi Yamashita; Manabu Abe; Kenji Sakimura; Tomotake Kanki; David C. Chan ABSTRACT Male germline development involves choreographed changes to mitochondrial number, morphology and organization. Mitochondrial reorganization during spermatogenesis...
Includes: Supplementary data
Journal Articles
Yuki Kobayashi, Shin-ichi Tomizawa, Michio Ono, Kazushige Kuroha, Keisuke Minamizawa, Koji Natsume, Selma Dizdarević, Ivana Dočkal, Hiromitsu Tanaka, Tatsukata Kawagoe, Masahide Seki, Yutaka Suzuki, Narumi Ogonuki, Kimiko Inoue, Shogo Matoba, Konstantinos Anastassiadis, Nobuhisa Mizuki, Atsuo Ogura, Kazuyuki Ohbo
Journal:
Development
Development (2021) 148 (8): dev196212.
Published: 26 April 2021
...; Kazuyuki Ohbo ABSTRACT During spermatogenesis, intricate gene expression is coordinately regulated by epigenetic modifiers, which are required for differentiation of spermatogonial stem cells (SSCs) contained among undifferentiated spermatogonia. We have previously found that KMT2B conveys H3K4me3...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Xiaoli Wang, Yujiao Wen, Jin Zhang, Grace Swanson, Shuangshuang Guo, Congcong Cao, Stephen A. Krawetz, Zhibing Zhang, Shuiqiao Yuan
Journal:
Development
Development (2021) 148 (7): dev196295.
Published: 15 April 2021
...Xiaoli Wang; Yujiao Wen; Jin Zhang; Grace Swanson; Shuangshuang Guo; Congcong Cao; Stephen A. Krawetz; Zhibing Zhang; Shuiqiao Yuan ABSTRACT Mitochondria play a crucial role in spermatogenesis and are regulated by several mitochondrial fusion proteins. However, their functional importance...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2021) 148 (5): dev195875.
Published: 5 March 2021
... is identified as an essential factor for C. elegans spermatogenesis, functioning with the kinase SPE-6 to sequester the cytoskeletal element MSP into fibrous bodies. Major sperm protein Intrinsically disordered protein Caenorhabditis elegans Spermatogenesis Cytoskeletal assembly spe-18...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2020) 147 (22): dev189811.
Published: 29 November 2020
... mutants. In contrast to bmpr2a , the loss of bmpr2b ( bmpr2b −/− ) had no effect on males, which showed normal testicular development and spermatogenesis. By contrast, the female bmpr2b mutant showed severe reproductive defects. The mutant females were infertile because the follicles could grow only...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
James Matthew Ragle, Abigail L. Aita, Kayleigh N. Morrison, Raquel Martinez-Mendez, Hannah N. Saeger, Guinevere A. Ashley, Londen C. Johnson, Katherine A. Schubert, Diane C. Shakes, Jordan D. Ward
Journal:
Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
...James Matthew Ragle; Abigail L. Aita; Kayleigh N. Morrison; Raquel Martinez-Mendez; Hannah N. Saeger; Guinevere A. Ashley; Londen C. Johnson; Katherine A. Schubert; Diane C. Shakes; Jordan D. Ward ABSTRACT In sexually reproducing metazoans, spermatogenesis is the process by which uncommitted germ...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
...-seq Germ cells Proliferation Differentiation Spermatogenesis Drosophila Maintenance of a multicellular organism during homeostasis and tissue repair requires active replenishment of depleted or injured cells during aging and regeneration. Adult stem cells fulfill this requirement owing...
Includes: Supplementary data
Journal Articles
Guihua Du, Xinrui Wang, Mengcheng Luo, Weiya Xu, Tao Zhou, Mei Wang, Luping Yu, Lufan Li, Li'e Cai, P. Jeremy Wang, John Zhong Li, Jon M. Oatley, Xin Wu
Journal:
Development
Development (2020) 147 (8): dev184655.
Published: 12 April 2020
...Guihua Du; Xinrui Wang; Mengcheng Luo; Weiya Xu; Tao Zhou; Mei Wang; Luping Yu; Lufan Li; Li'e Cai; P. Jeremy Wang; John Zhong Li; Jon M. Oatley; Xin Wu ABSTRACT Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Yu Jiang, Hui-Ying Zhang, Zhen Lin, Ye-Zhang Zhu, Chao Yu, Qian-Qian Sha, Ming-Han Tong, Li Shen, Heng-Yu Fan
Journal:
Development
Development (2020) 147 (6): dev183764.
Published: 17 March 2020
... with spermatogenesis arrested at MII. Knockout of Cxxc1 led to a decrease in the H3K4me3 level from the pachytene to the MII stage and caused transcriptional disorder. Many spermatogenesis pathway genes were expressed early leading to abnormal acrosome formation in arrested MII cells. In meiotic prophase, deletion...
Includes: Supplementary data
Journal Articles
Stefano Sechi, Anna Frappaolo, Angela Karimpour-Ghahnavieh, Marco Gottardo, Romina Burla, Laura Di Francesco, Edith Szafer-Glusman, Eugenia Schininà, Margaret T. Fuller, Isabella Saggio, Maria Giovanna Riparbelli, Giuliano Callaini, Maria Grazia Giansanti
Journal:
Development
Development (2019) 146 (22): dev183053.
Published: 18 November 2019
... of Drosophila gametogenesis, spermatocytes undergo robust gene transcription and store many transcripts in the cytoplasm in a repressed state, until translational activation of select mRNAs in later steps of spermatogenesis. Here, we characterize the Drosophila Doublefault (Dbf) protein as a C2H2 zinc-finger...
Includes: Supplementary data