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Keywords: Spermatocyte
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (14): dev201557.
Published: 19 July 2023
..., the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP translocates from the cytosol to the nucleus as germ cells transition into the meiotic spermatocyte stage. Importantly, nuclear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev197780.
Published: 10 February 2021
... to male meiosis remains poorly understood. Here, we characterize the G33S mutation in the C. elegans dynactin subunit DNC-1, which corresponds to G59S in human p150 Glued that causes motor neuron disease. In spermatocytes, dnc-1(G33S) delays spindle assembly and penetrantly inhibits anaphase spindle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3522–3531.
Published: 1 September 2013
... contributes predominantly to maintaining the free ubiquitin pool in testes. The function of Ubi-p63E is required cell-autonomously for proper meiotic chromatin condensation, cell cycle progression and spermatid differentiation. magn mutant germ cells develop normally to the spermatocyte stage but arrest...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 23–30.
Published: 1 January 2013
... and proliferative state, as well as the subsequent commitment to proper terminal differentiation. In the Drosophila male germline stem cell (GSC) lineage, a key differentiation factor, Bag of marbles (Bam), is required for the transition from proliferative spermatogonia to differentiating spermatocytes. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2441–2450.
Published: 15 June 2011
... developmentally regulated sequential events at promoters once cells commit to spermatocyte differentiation. The programmed events include global downregulation of Polycomb repressive complex 2 (PRC2) components, recruitment of hypophosphorylated RNA polymerase II (Pol II) to promoters, as well as the expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (15): 2863–2869.
Published: 1 August 2007
... of the translation initiation complex component eIF4G in Drosophila , eIF4G2, is required specifically for male germ cells to undergo meiotic division and proper spermatid differentiation. Flies mutant for eIF4G2 are viable and female fertile but male sterile. Spermatocytes form, but the germ cells in mutant males...
Journal Articles
Journal: Development
Development (2004) 131 (21): 5297–5308.
Published: 1 November 2004
...-specific gene expression programs during cellular differentiation. The cannonball ( can ) gene of Drosophila encodes a homolog of a TBP-associated factor (dTAF5) protein expressed only in spermatocytes, where it is required for normal transcription of genes required for spermatid differentiation. We show...
Journal Articles
Journal: Development
Development (2003) 130 (13): 2841–2852.
Published: 1 July 2003
.... Homozygous mutant flies are viable and appear morphologically normal, but the males are completely sterile. The defect lies at the primary spermatocyte stage and differentiation is blocked prior to the onset of the meiotic divisions. We show that mutants lacking TGIF function fail to activate transcription...