... 2009. 2009 RDH10 Retinol dehydrogenase Short chain dehydrogenase/reductase Retinoic acid Morphogen Gradient Spemann's organizer Gastrulation Induction Pattern formation Hindbrain CNS Xenopus Regional specification is a fundamental process during early development of the central...

... of Spemann’s organizer in Xenopus . The role of Gsc in organizer function was examined by fusing defined transcriptional regulatory domains to the Gsc homeodomain. Like native Gsc, ventral injection of an Engrailed repressor fusion (Eng-Gsc) induced a partial axis, while a VP16 activator fusion (VP16-Gsc) did...

... can still respond to anteroposterior positional information. * Corresponding author (e-mail: i45239a@nucc.cc.nagoya-u.ac.jp ) 09 03 1998 22 04 1998 © 1998 by Company of Biologists 1998 Neural induction otx2 hoxa-1 Spemann’s organizer Embryonic shield Mesoderm...

... suggest that cortical rotation distributes Wnt-like dorsal determinants to the dorsal side of the embryo, including the dorsal marginal zone, and that these determinants may directly establish Spemann’s organizer in this region. * These authors contributed equally † Present address...

...Maximilian Fürthauer; Christine Thisse; Bernard Thisse ABSTRACT Signals released from Spemann’s organizer, together with ventralizing factors such as BMPs, are necessary to pattern the dorsoventral axis of the vertebrate embryo. We report that a member of the FGF family, fgf-8 , not secreted...

... dorsoposterior side of the embryo. On arrival at their destination, the activated determinants form, in all chordates, an induction center homologous to the amphibian ‘Nieuwkoop center’, which induces the formation of ‘Spemann’s organizer’. On the basis of the above general scenario, a revision is proposed...

...Samir E. Witta; Sheryl M. Sato ABSTRACT XlPOU 2 , a member of the class III POU-domain family, is expressed initially at mid-blastula transition (MBT) and during gastrulation in the entire marginal zone mesoderm, including Spemann’s Organizer (the Organizer). To identify potential targets of XlPOU...

...Ira L. Blitz; W. Y. Cho ABSTRACT In order to study the regional specification of neural tissue we isolated Xotx2 , a Xenopus homolog of the Drosophila orthodenticle gene. Xotx2 is initially expressed in Spemann’s organizer and its expression is absent in the ectoderm of early gastrulae...

...Eddy M. De Robertis; Martin Blum; Christof Niehrs; Herbert Steinbeisser The molecular nature of Spemann’s organizer phenomenon has long attracted the attention of embryologists. goosecoid is a homeobox gene with a DNA-binding specificity similar to that of Drosophila bicoid. Xenopus goosecoid...